Metabolism of dichloroethylene by CYP450 (WP3666)

Homo sapiens

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This pathway describes the metabolism of dichloroethylene by Cytochrome P450 enzymes. Source: [http://www.kegg.jp/pathway/ko00980 KEGG Metabolism of xenobiotics by cytochrome P450].

Authors

Jacob Windsor , Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Elisa Cirillo , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
2-S-Glutathionyl acetate Metabolite pubchem.compound:11954071
Chloroacetic acid Metabolite hmdb:HMDB0031331
S-(2-Chloroacetyl)glutathione Metabolite hmdb:HMDB0060505
2-(S-Glutathionyl)acetyl chloride Metabolite hmdb:HMDB0060342
2,2-dichloro-1,1-ethanediol Metabolite pubchem.compound:85275
1,1-Dichloroethylene Metabolite pubchem.compound:6366
1,1-Dichloroethylene epoxide Metabolite hmdb:HMDB0060333
Chloroacetyl chloride Metabolite hmdb:HMDB0060452
S-(2,2-dichloro-1-hydroxy)-1-ethyl glutathione Metabolite pubchem.compound:11954070
2,2-Dichloroacetaldehyde Metabolite hmdb:HMDB0060357
CYP2E1 GeneProduct ensembl:ENSG00000130649
CYP2E1 GeneProduct ensembl:ENSG00000130649
CYP2E1 GeneProduct ensembl:ENSG00000130649
glutathione S-transferase Protein kegg.genes:119391
glutathione S-transferase Protein kegg.genes:119391
glutathione S-transferase Protein kegg.genes:119391

References

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  3. Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR. Chem Res Toxicol. 1999 Sep;12(9):831–9. PubMed Europe PMC Scholia
  4. Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats. Halladay JS, Sauer JM, Sipes IG. Drug Metab Dispos. 1999 Dec;27(12):1456–65. PubMed Europe PMC Scholia
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  7. Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, et al. Cancer Epidemiol Biomarkers Prev. 2004 Aug;13(8):1342–8. PubMed Europe PMC Scholia
  8. Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes. Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, et al. Drug Metab Dispos. 2004 Sep;32(9):1032–9. PubMed Europe PMC Scholia
  9. Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1. Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, et al. Drug Metab Dispos. 2005 Oct;33(10):1429–37. PubMed Europe PMC Scholia