Glucose homeostasis (WP661)

Homo sapiens

An organism-level overview of Glucose homeostasis. At this moment the focus is on metabolites that can be measured in the plasma, but it would be nice to show the interaction between the different organs (Adipose tissue, Liver, Intestine, Muscle) as well as the involvement of hormones other than insulin


Martijn Van Iersel , Kristina Hanspers , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

glucose homeostasis pathway


Label Type Compact URI Comment
Glycerol Metabolite hmdb:HMDB0000131
Isoleucine Metabolite hmdb:HMDB0000172
Methionine Metabolite hmdb:HMDB0000696
GCA Metabolite hmdb:HMDB0000138
Glucose Metabolite hmdb:HMDB0000122
Ornithine Metabolite hmdb:HMDB0000214
Lactate Metabolite hmdb:HMDB0000190
Arginine Metabolite hmdb:HMDB0000517
Hypoxanthine Metabolite hmdb:HMDB0000157
Histidine Metabolite hmdb:HMDB0000177
B-OH-butyrate Metabolite hmdb:HMDB0000011
GCDCA Metabolite hmdb:HMDB0000637
Pyruvate Metabolite hmdb:HMDB0000243
TCDCA Metabolite hmdb:HMDB0000951
Malate Metabolite hmdb:HMDB0000156
Tyrosine Metabolite hmdb:HMDB0000158
Phenylalanine Metabolite hmdb:HMDB0000159
Citrulline Metabolite hmdb:HMDB0000904
Lysine Metabolite hmdb:HMDB0000182
Hippuric acid Metabolite hmdb:HMDB0000714
valine Metabolite hmdb:HMDB0000883
Insulin GeneProduct ensembl:ENSG00000254647


  1. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, et al. Mol Syst Biol. 2008;4:214. PubMed Europe PMC Scholia