UDP-derived sugars synthesis in fibroblasts (WP5394)

One of the main roles of fibroblasts is the secretion of the extracellular matrix components such as glycosaminoglycans (GAGs). This pathway describes the synthesis of GAGs precursors - five UDP-derived sugars (UDP-α-D-galactose, UDP-α-D-glucuronate, UDP-α-D-xylose, UDP-N-acetyl-α-D-galactosamine, UDP-N-α-alpha-D-glucosamine). It takes place in the cytosol, where it starts with the conversion of D-glucopyranose to D-glucopyranose 6-phosphate, after which it can either proceed via a shorter or a longer path. The shorter leads to the synthesis of UDP-α-D-galactose, UDP-α-D-glucuronate and UDP-α-D-xylose, while the longer leads to the synthesis of UDP-N-acetyl-α-D-galactosamine and UDP-N-acetyl-α-D-glucosamine. Some of the enzymes are missing in the pathway and can be a subject for future research. This pathway was created based on the pathway information from the MetaCyc database (see Bibliography).

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