Leptin-insulin signaling overlap (WP578)

Mus musculus

Overlap of cellular insulin and leptin signaling


Susan Coort , Chris Evelo , Martijn Van Iersel , Thomas Kelder , Samuel Sklar , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz


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Mus musculus



Pathway Ontology

leptin system pathway insulin signaling pathway


Label Type Compact URI Comment
PIP2 Metabolite chebi:18348
PIP3 Metabolite chebi:16618
Jak2 GeneProduct ncbigene:16452
PDK1 GeneProduct ncbigene:18607
Lepr GeneProduct ncbigene:16847
Socs3 GeneProduct ncbigene:12702
Stat3 GeneProduct ncbigene:20848
P85 GeneProduct ensembl:ENSMUSG00000028698
Akt1/PKB GeneProduct ncbigene:11651
Socs2 GeneProduct ncbigene:216233
P110 GeneProduct ensembl:ENSMUSG00000020573
Insr GeneProduct ncbigene:16337
Socs1 GeneProduct ncbigene:12703
Insulin GeneProduct ncbigene:16333
Jak2 GeneProduct ncbigene:16452
PKC GeneProduct ensembl:ENSMUSG00000040479
Stat3 GeneProduct ncbigene:20848
Leptin GeneProduct uniprot:P41160
Irs1 GeneProduct ncbigene:16367
P110 GeneProduct ensembl:ENSMUSG00000020573
Irs2 GeneProduct ncbigene:384783
Irs3 GeneProduct ncbigene:16369
Jak2 GeneProduct ncbigene:16452
Stat3 GeneProduct ncbigene:20848
Irs4 GeneProduct ncbigene:16370


  1. Activation of downstream signals by the long form of the leptin receptor. Banks AS, Davis SM, Bates SH, Myers MG Jr. J Biol Chem. 2000 May 12;275(19):14563–72. PubMed Europe PMC Scholia