Exercise-induced circadian regulation (WP410)

Homo sapiens

Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianally regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianally regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianally regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively. Based on [https://www.ncbi.nlm.nih.gov/pubmed/14519196 Zambon et al, Genome Biol. 2003;4(10):R61]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP410 CPTAC Assay Portal]


Alexander C. Zambon , Thomas Kelder , Alex Pico , Kristina Hanspers , Martijn Van Iersel , Martina Summer-Kutmon , Andika Tan , and Eric Weitz


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Homo sapiens



Pathway Ontology

regulatory pathway

Cell Type Ontology

cell of skeletal muscle


Label Type Compact URI Comment
MYF6 GeneProduct ncbigene:4618 102265 at
KLF9 GeneProduct ncbigene:687 93527 at
HERPUD1 GeneProduct ncbigene:9709 95057 at
SF3A3 GeneProduct ncbigene:10946 96029 at
CBX3 GeneProduct ncbigene:11335 100405 at
AZIN1 GeneProduct ncbigene:51582 101002 at
PSMA4 GeneProduct ncbigene:5685 97459 at
ZFR GeneProduct ncbigene:51663 104050 at
SUMO1 GeneProduct ncbigene:7341 101091 at
HIST1H2BN GeneProduct ncbigene:8341 93833 s at
PURA GeneProduct ncbigene:5813 103501 at
CRY2 GeneProduct ncbigene:1408
PER1 GeneProduct ncbigene:5187
PER2 GeneProduct ncbigene:8864
CRY1 GeneProduct ncbigene:1407
PPP1R3C GeneProduct ncbigene:5507 93933 at
CEBPB GeneProduct ncbigene:1051 92925 at
PPP2CB GeneProduct ncbigene:5516 101101 at
NCOA4 GeneProduct ncbigene:8031 97843 at
ETV6 GeneProduct ncbigene:2120 93866 s at
CAST GeneProduct ncbigene:26059 93829 at
HLA-DMA GeneProduct ncbigene:3108 162346 f at
HSPA8 GeneProduct ncbigene:3312 96564 at
DNAJA1 GeneProduct ncbigene:3301 97261 at
UCP3 GeneProduct ncbigene:7352 93392 at
GSTM3 GeneProduct ncbigene:2947 97681 f at
UGP2 GeneProduct ncbigene:7360 94481 at
CLDN5 GeneProduct ncbigene:7122 104516 at
PIGF GeneProduct ncbigene:5281 104725 at
TUBB3 GeneProduct ncbigene:10381 94835 f at
GFRA1 GeneProduct ncbigene:2674 93872 at
MAP3K7IP2 GeneProduct ncbigene:23118 160309 at
SUMO3 GeneProduct ncbigene:6612 95424 at
GSTP1 GeneProduct ncbigene:2950 99583 at
NCKAP1 GeneProduct ncbigene:10787 95508 at
VAPA GeneProduct ncbigene:9218 94889 at
GENX-3414 GeneProduct ncbigene:8987 104116 at
DAZAP2 GeneProduct ncbigene:9802 94454 at
IDI1 GeneProduct ncbigene:3422 96269 at
TOB1 GeneProduct ncbigene:10140 99532 at
RBPMS GeneProduct ncbigene:11030 103888 at
G0S2 GeneProduct ncbigene:50486 97531 at
ARNTL GeneProduct ncbigene:406
NR1D2 GeneProduct ncbigene:9975 99076 at
CLOCK GeneProduct ncbigene:9575
BTG1 GeneProduct ncbigene:694 93104 at
EIF4G2 GeneProduct ncbigene:1982 100535 at
QKI GeneProduct ncbigene:9444 95096 at (mouse)
PER1 GeneProduct ncbigene:5187
PER2 GeneProduct ncbigene:8864
CRY1 GeneProduct ncbigene:1407
CRY2 GeneProduct ncbigene:1408
CRY2 GeneProduct ncbigene:1408
CRY1 GeneProduct ncbigene:1407
PER2 GeneProduct ncbigene:8864
PER1 GeneProduct ncbigene:5187


  1. Extensive and divergent circadian gene expression in liver and heart. Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, et al. Nature. 2002 May 2;417(6884):78–83. PubMed Europe PMC Scholia
  2. Coordinated transcription of key pathways in the mouse by the circadian clock. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, et al. Cell. 2002 May 3;109(3):307–20. PubMed Europe PMC Scholia
  3. Time- and exercise-dependent gene regulation in human skeletal muscle. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, et al. Genome Biol. 2003;4(10):R61. PubMed Europe PMC Scholia