Striated muscle contraction pathway (WP383)

Homo sapiens

Muscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In the case of voluntary action, the nervous signals are initiated from the brain by so-called action potentials. With reflexes, these potentials are coming directly from the spinal cord. Striated muscles are a group of muscles also called skeletal and cardiac muscle tissue. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal].


Nathan Salomonis , Martijn Van Iersel , Joanna Fong , Kristina Hanspers , Andra Waagmeester , Marianthi Kalafati , Marvin Martens , Friederike Ehrhart , Eric Weitz , and Martina Summer-Kutmon


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Homo sapiens



Pathway Ontology

regulatory pathway

Cell Type Ontology

striated muscle cell


Label Type Compact URI Comment
TNNI3 GeneProduct ncbigene:7137
DES GeneProduct ncbigene:1674
MYBPC1 GeneProduct ncbigene:4604
TCAP GeneProduct ncbigene:8557
TNNI1 GeneProduct ncbigene:7135
MYOM1 GeneProduct ncbigene:8736
ACTA2 GeneProduct ncbigene:59
ACTG1 GeneProduct ncbigene:71
TNNT1 GeneProduct ncbigene:7138
ACTA1 GeneProduct ncbigene:58
MYL4 GeneProduct ncbigene:4635
TNNI2 GeneProduct ncbigene:7136
MYBPC3 GeneProduct ncbigene:4607
MYH6 GeneProduct ncbigene:4624
TNNC1 GeneProduct ncbigene:7134
TPM2 GeneProduct ncbigene:7169
TNNC2 GeneProduct ncbigene:7125
VIM GeneProduct ncbigene:7431
TPM3 GeneProduct ncbigene:7170
MYL3 GeneProduct ncbigene:4634 MLEV HUMAN
MYL2 GeneProduct ncbigene:4633
NEB GeneProduct ncbigene:4703
ACTN3 GeneProduct ncbigene:89 AAC3 MOUSE
MYH8 GeneProduct ncbigene:4626
ACTC GeneProduct ncbigene:70
MYH3 GeneProduct ncbigene:4621
TPM4 GeneProduct ncbigene:7171
TTN GeneProduct ncbigene:7273 similiar to hs: Q10465
TNNT3 GeneProduct ncbigene:7140
TNNT2 GeneProduct ncbigene:7139
MYL9 GeneProduct ncbigene:10398
MYBPC2 GeneProduct ncbigene:4606
DMD GeneProduct ncbigene:1756
ACTN4 GeneProduct ncbigene:81
TMOD1 GeneProduct ncbigene:7111
ACTN2 GeneProduct ncbigene:88 AAC2 MOUSE
TPM1 GeneProduct ncbigene:7168 p10469
MYL1 GeneProduct ncbigene:4632