Canonical and non-canonical TGF-B signaling (WP3874)
This pathway is modeled after Figure 9 in the article "Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells". Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin's ability to bock the BMP signaling pathway which inhibits TGF-B receptors. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3874 CPTAC Assay Portal]
AuthorsAAR&Co , Friederike Ehrhart , Kristina Hanspers , and Eric Weitz
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Disease Ontologyprimary angle-closure glaucoma
Pathway OntologyBone morphogenetic proteins signaling pathway
- Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Sethi A, Wordinger RJ, Clark AF. Exp Eye Res. 2013 Aug;113:117–27. PubMed Europe PMC Scholia