Canonical and non-canonical TGF-B signaling (WP3874)
Homo sapiens
This pathway is modeled after Figure 9 in the article "Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells". Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin's ability to bock the BMP signaling pathway which inhibits TGF-B receptors. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3874 CPTAC Assay Portal]
Authors
AAR&Co , Friederike Ehrhart , Kristina Hanspers , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Annotations
Disease Ontology
primary angle-closure glaucomaPathway Ontology
Bone morphogenetic proteins signaling pathwayCell Type Ontology
trabecular meshwork cellReferences
- Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Sethi A, Wordinger RJ, Clark AF. Exp Eye Res. 2013 Aug;113:117–27. PubMed Europe PMC Scholia