Ketone bodies synthesis and degradation (WP898)

Pan troglodytes

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]


Thomas Kelder , Egon Willighagen , Kristina Hanspers , Daniela Digles , , and Eric Weitz


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Pan troglodytes



Pathway Ontology

ketone bodies metabolic pathway


Label Type Compact URI Comment
Acetyl-CoA Metabolite cas:72-89-9
Acetoacetyl-CoA Metabolite cas:1420-36-6
3-Hydroxy-3-methylglutaryl-CoA Metabolite cas:1553-55-5
Acetyl-CoA Metabolite cas:72-89-9
3-Hydroxy-butyrate Metabolite pubchem.compound:441
Acetoacetate Metabolite pubchem.compound:6971017
ACAT1 GeneProduct ncbigene:451528
HMGCS2 GeneProduct ncbigene:457169
HMGCL GeneProduct ncbigene:456624
OXCT1 GeneProduct ncbigene:737468
BDH1 GeneProduct ncbigene:460970


  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia