Mitochondrial immune response to SARS-CoV-2 (WP5038)

Homo sapiens

SARS-CoV-2 mitochondrial immune response

Authors

Gabriel Couillaud , Claire Billingsley , Egon Willighagen , Friederike Ehrhart , Eric Weitz , Finterly Hu , Kingson ''junsheng Thang'' Luc , and Nhung Pham

Activity

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Cited In

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

disease pathway immune response pathway

Disease Ontology

COVID-19 severe acute respiratory syndrome

Participants

Label Type Compact URI Comment
cGAMP Metabolite chebi:71580
ROS Metabolite chebi:26523
angiotensin-(1-9) Metabolite chebi:80128
angiotensin II Metabolite chebi:2719 ang II accumulation
angiotensin I Metabolite chebi:2718
AGT Metabolite chebi:2720
angiotensin (1-7) Metabolite chebi:55438
AGTR2 GeneProduct ensembl:ENSG00000180772
MAS1 GeneProduct ensembl:ENSG00000206470
NOX1 GeneProduct uniprot:Q9Y5S8
AGTR1 GeneProduct ensembl:ENSG00000144891
cGAS GeneProduct uniprot:Q8N884
ACAD9 GeneProduct ensembl:ENSG00000177646
NFKB1 GeneProduct ensembl:ENSG00000109320
DDX58 GeneProduct ensembl:ENSG00000107201
IFIH1 GeneProduct hgnc.symbol:IFIH1
NDUFAF1 GeneProduct ensembl:ENSG00000137806
BCS1L GeneProduct ensembl:ENSG00000074582
ECSIT GeneProduct ensembl:ENSG00000130159
NDUFB9 GeneProduct ensembl:ENSG00000147684
IKBKE GeneProduct ensembl:ENSG00000263528
CTSL GeneProduct ensembl:ENSG00000135047
IRF3 GeneProduct ensembl:ENSG00000126456
NFKB2 GeneProduct ensembl:ENSG00000077150
TBK1 GeneProduct ensembl:ENSG00000183735
NLRX1 GeneProduct ensembl:ENSG00000160703
IRF3 GeneProduct ensembl:ENSG00000126456
TMPRSS2 GeneProduct ensembl:ENSG00000184012
ACE2 GeneProduct uniprot:Q9BYF1
IFN-I GeneProduct ncbigene:3438
TMEM173 GeneProduct uniprot:Q86WV6 STING1
TLR3 GeneProduct ensembl:ENSG00000164342
TICAM1 GeneProduct ncbigene:148022 TRIF
nsp13 GeneProduct wikidata:Q94648377
orf6 GeneProduct uniprot:P0DTC6
TRAF6 GeneProduct ensembl:ENSG00000175104
TRAF3 GeneProduct ensembl:ENSG00000131323
MAVS GeneProduct ensembl:ENSG00000088888
PHB GeneProduct uniprot:P35232
PHB2 GeneProduct uniprot:Q99623
TLR7 GeneProduct ensembl:ENSG00000196664
IRF7 GeneProduct ensembl:ENSG00000185507
S2 Protein wikidata:Q106020384 S2 subunit
S1 Protein wikidata:Q106020256 S1 subunit
HSP90 Protein ensembl:ENSG00000080824.19
orf9c Protein wikidata:Q104520877
nsp7 Protein uniprot:P0DTD1
ACE Protein uniprot:P12821
Renin Protein uniprot:A0A1B0GUZ2
Nucleoprotein N Protein uniprot:P0DTC9
Spike Glycoprotein S Protein uniprot:P0DTC2
Envelope Protein E Protein uniprot:P0DTC4
Membrane Glycoprotein M Protein uniprot:P0DTC5
nsp6 Protein ncbiprotein:YP_009725302
orf9b Protein uniprot:P0DTD2 promotes mitochondrial fusion
TOMM70 Protein ensembl:ENSG00000154174
nsp2 Protein uniprot:P0DTD1 impairs intra- cellular signaling and mitochondrial biogenesis
PLpro Protein uniprot:P0DTD2

References

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