Glyoxylate, anapleurotic and succinyl CoA (GAS) pathway (WP2638)

Mycobacterium tuberculosis

Schematic of the GAS pathway which is characterised by flux through the glyoxylate shunt and anaplerotic reactions for oxidation of pyruvate and succinyl CoA synthetase for the generation of succinyl CoA. From: (


Andra Waagmeester , Egon Willighagen , Marianthi Kalafati , Friederike Ehrhart , and Eric Weitz


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Mycobacterium tuberculosis



Pathway Ontology

classic metabolic pathway


Label Type Compact URI Comment
Succinyl-CoA Metabolite chemspider:83179
Succinate Metabolite chemspider:140973
CO2 Metabolite chemspider:274
Oxaloacetate Metabolite chemspider:2509917
phosphoenolpyruvate Metabolite chemspider:980
glyoxylate Metabolite chemspider:2849615
L-Malate Metabolite chemspider:4573566
Citrate Metabolite chemspider:29081
02 Metabolite chemspider:952
Isocitrate Metabolite chemspider:4573809
Pyruvate Metabolite chemspider:96901
CO2 Metabolite chemspider:274
Succinyl-CoA Metabolite chemspider:83179
CO2 Metabolite chemspider:274


  1. ¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation. Beste DJV, Bonde B, Hawkins N, Ward JL, Beale MH, Noack S, et al. PLoS Pathog. 2011 Jul;7(7):e1002091. PubMed Europe PMC Scholia