Small ligand GPCRs (WP161)

Rattus norvegicus

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] These small ligand receptors are part of the Rhodopsin-like family of GPCRs. Source: [ Wikipedia]


Nathan Salomonis , Manny Ramirez , Daniela Digles , Egon Willighagen , Kristina Hanspers , and Eric Weitz


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Rattus norvegicus



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Melatonin Metabolite chebi:16796
Cannabinoid Metabolite chebi:67194
Prostanoids Metabolite chebi:26347
Cnr1 GeneProduct ncbigene:25248
Cnr2 GeneProduct ncbigene:57302
S1pr1 GeneProduct ncbigene:29733
Lpar1 GeneProduct ncbigene:116744
S1pr3 GeneProduct ncbigene:306792
S1pr2 GeneProduct ncbigene:29415
S1pr4 GeneProduct ncbigene:314649
Mtnr1a GeneProduct ncbigene:114211
Ptafr GeneProduct ncbigene:58949
PTGDR GeneProduct ncbigene:498475
Ptger1 GeneProduct ncbigene:25637
Ptger2 GeneProduct ncbigene:81752
Ptger3 GeneProduct ncbigene:24929
Ptger4 GeneProduct ncbigene:84023
Ptgfr GeneProduct ncbigene:25652
Ptgir GeneProduct ncbigene:292661
Tbxa2r GeneProduct ncbigene:24816
Mtnr1b GeneProduct ncbigene:192646