Renin-angiotensin system (WP376)

Rattus norvegicus

This pathway is based on the [ KEGG pathway] of renin-angiotensin and the [ Ambion pathway] of renin-angiotensin


Rishi , Mark Van Grinsven , Thomas Kelder , Chris Evelo , Daniela Digles , Martina Summer-Kutmon , Agustin Gonzalez-Vicente , Egon Willighagen , Denise Slenter , Kristina Hanspers , and Eric Weitz


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Rattus norvegicus


Renal Genomics Pathways


Disease Ontology

renal hypertension hypertension

Pathway Ontology

renin-angiotensin cascade pathway


Label Type Compact URI Comment
Angiotensin 1 Metabolite hmdb:HMDB0061196
PIP2 Metabolite chebi:18348
Angiotensin III Metabolite hmdb:HMDB0001036
ROS Metabolite chebi:26523
CA2+ Metabolite hmdb:HMDB0000464
IP3 Metabolite hmdb:HMDB0001143
cAMP Metabolite hmdb:HMDB0000058
Ceramide Metabolite chebi:17761
DAG Metabolite chebi:18035
Angiotensin (1-5) Metabolite chebi:80129
Angiotensin IV Metabolite hmdb:HMDB0001038
Angiotensin (1-9) Metabolite chebi:80128
Angiotensin II Metabolite hmdb:HMDB0001035
Angiotensin (1-7) Metabolite pubchem.compound:123805
NO Metabolite hmdb:HMDB0003378
Fos GeneProduct ensembl:ENSRNOG00000008015
Ace Protein rgd:2493
IP3R Protein interpro:IPR000493
Ikbkg Protein ensembl:ENSRNOG00000060936
Itpr3 Protein rgd:2934
c-Jun Protein rgd:2943
PAK2 Protein rgd:61953
Itpr1 Protein rgd:2933
Ppgb Protein rgd:1309070
TYK Protein ensembl:ENSRNOG00000032948
Mme Protein rgd:3098
ERK1 Protein rgd:70500
Itpr2 Protein rgd:69649
Grb2 Protein ncbigene:81504
Mme Protein rgd:3098
MEKK1 Protein rgd:620966
Enpep Protein rgd:621228
PPtase Protein rgd:62018
Ace Protein rgd:2493
Prkcq Protein rgd:620968
Mapk10 Protein rgd:3663
PAK7 Protein rgd:1312009
Mapk9 Protein rgd:628847
AC2/3 Protein rgd:2036
Ikbkb Protein rgd:621375
FAK Protein rgd:3443
PAK4 Protein rgd:1307705
Mapk3 Protein ensembl:ENSRNOG00000053583
CTSG Protein rgd:1307681
Ras Protein rgd:2981
Thop1 Protein rgd:68330
Mas1 Protein rgd:3049
Ace Protein rgd:2493
Anpep Protein rgd:2991
ATF2 Protein ncbigene:81647
TYK Protein ensembl:ENSRNOG00000032948 Assuming this protein stands for TYK2 (it seems TYK1 is not related to this interaction).
Jak2 Protein ensembl:ENSRNOG00000059968
NF-KB Protein rgd:727889
PAK Protein eccode: Cannot find a more specific identifier in this context, see as a start.
STAT3 Protein rgd:3772
Plcb1 Protein rgd:3344
Cpa3 Protein rgd:2390
PAK6 Protein rgd:1306213
Mapk8 Protein rgd:621506
Lnpep Protein rgd:621752
Rac1 Protein rgd:619755
STAT1 Protein rgd:3771
Ace2 Protein rgd:728890
PtgIR Protein ncbigene:292661
PYK2 Protein rgd:628758
Nln Protein rgd:621518
GalfaQ/11 Protein uniprot:Q9JID2
Angiotensinogen Protein rgd:2069
Agtr2 Protein rgd:2072
CMA1 Protein rgd:2365
Raf1 Protein ncbigene:24703
PKA Protein rgd:3389
MEKK1 Protein rgd:620966
PAK3 Protein rgd:3251
Agtr1a Protein rgd:2070
p38 Protein rgd:3045
SHC Protein ensembl:ENSRNOG00000020657 Mapping based on name of ortholog human gene.
JNK Protein ensembl:ENSRNOG00000020155
MKK4 Protein rgd:1307040
Ace2 Protein rgd:728890
Renin Protein rgd:3554
PAK1 Protein rgd:3250
MKK7 Protein rgd:1560043
SOS Protein interpro:IPR023578 Unclear which ortholog is meant, see also:
Elk1 Protein rgd:1598663
PI3K Protein ensembl:ENSRNOG00000056371 Identifier based on similar name for ortholog human gene


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  91. Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system. Fernando RN, Larm J, Albiston AL, Chai SY. J Comp Neurol. 2005 Jul 11;487(4):372–90. PubMed Europe PMC Scholia
  92. Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells. Schmid C, Ghirlanda-Keller C, Gosteli-Peter M. Regul Pept. 2005 Aug 15;130(1–2):57–66. PubMed Europe PMC Scholia
  93. The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Kim JS, Jobin C. Immunology. 2005 Jul;115(3):375–87. PubMed Europe PMC Scholia
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