AlexanderPico

Primary focal segmental glomerulosclerosis (FSGS)

GABA receptor signaling

ATM signaling

Senescence and autophagy in cancer

Wnt signaling

Wnt signaling, NetPath

Cholesterol biosynthesis pathway

Vitamin A and carotenoid metabolism

Pluripotent stem cell differentiation pathway

Methionine degradation

NAD biosynthesis II from tryptophan

Parkinson's disease pathway

Homocysteine and cysteine interconversion

Estrogen receptor pathway

Estrogen signaling

Pathways into methionine and folate cycles

Metabolic pathways of fibroblasts

DNA replication

One-carbon metabolism

Non-small cell lung cancer

Complement system

One-carbon metabolism

Glycine metabolism

Statin pathway

Regulation of Pgc1a expression by a Gsk3b-Tfeb signaling axis in skeletal muscle

Macrophage markers

PI3K/AKT/mTOR - vitamin D3 signaling

Angiopoietin-like protein 8 regulatory pathway

Mitochondrial long chain fatty acid beta-oxidation

BDNF-TrkB signaling

Interactions between LOXL4 and oxidative stress pathway

MECP2 and associated Rett syndrome

Methionine de novo and salvage pathway

Fatty acid biosynthesis

Melatonin metabolism and effects

Corticotropin-releasing hormone

Oncostatin M signaling

Alzheimer's disease and miRNA effects

Aerobic glycolysis - augmented

Neural crest cell migration during development

Parkin-ubiquitin proteasomal system pathway

TNF-related weak inducer of apoptosis (TWEAK) signaling

Effects of nitric oxide

Pregnane X receptor pathway

Gene regulatory network modeling somitogenesis

Endoderm differentiation

Hair follicle development: organogenesis - stage 2 of 3

Selenium metabolism and selenoproteins

Interleukin-1 (IL-1) structural pathway

Common pathways underlying drug addiction

Aryl hydrocarbon receptor pathway

HIF1A and PPARG in hypertrophic cardiomyopathy

Amyotrophic lateral sclerosis (ALS)

Cardiac progenitor differentiation

Histone modifications

Gastric cancer network 2

Gastric cancer network 1

Adipogenesis

Corticotropin-releasing hormone signaling

miRNA biogenesis

AGE/RAGE pathway

Chemokine signaling pathway

Glial cell differentiation

Pathogenic Escherichia coli infection

Androgen receptor network in prostate cancer

Glioblastoma signaling

Glycolysis and gluconeogenesis

Glycogen synthesis and degradation

Wnt signaling and pluripotency

NAD+ metabolism

Parkinson's disease

NAD metabolism, sirtuins and aging

Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling

Osteoblast signaling

Interleukin-11 signaling pathway

NRF2 pathway

Farnesoid X receptor pathway

PPAR-alpha pathway

Vitamin D receptor pathway

Constitutive androstane receptor pathway

Liver X receptor pathway

Aryl hydrocarbon receptor pathway

Cardiac hypertrophic response

Thymic stromal lymphopoietin (TSLP) signaling

IL9 signaling

Endothelin pathways

Arrhythmogenic right ventricular cardiomyopathy

IL7 signaling

Microtubule cytoskeleton regulation

Prolactin signaling

Mitochondrial fatty acid oxidation disorders

Fibrin complement receptor 3 signaling

Liver steatosis adverse outcome pathway

Prader-Willi and Angelman syndrome

IL4 signaling

NAD+ biosynthetic pathways

PDGF pathway

Hedgehog signaling

Type 2 papillary renal cell carcinoma

Nuclear receptors in lipid metabolism and toxicity

Ebstein-Barr virus LMP1 signaling

S1P receptor signal transduction

TNF-alpha signaling

Follicle stimulating hormone (FSH) signaling

Thyroid stimulating hormone (TSH) signaling

Cell differentiation - index

RANKL/RANK signaling

Integrated breast cancer pathway

Cori cycle

Eicosanoid synthesis

Lipoic acid metabolism

Fructose and mannose metabolism

Biotin metabolism

Ascorbate and aldarate metabolism

Nicotine effect on chromaffin cells

Nicotine effect on dopaminergic neurons

Glycogen metabolism

Type II diabetes mellitus

Histidine metabolism

MicroRNAs in cardiomyocyte hypertrophy

Vitamin B12 metabolism

Vitamin D metabolism

Metapathway biotransformation Phase I and II

Glucuronidation

Estrogen metabolism

Benzo(a)pyrene metabolism

Sulfation biotransformation reaction

T-cell receptor signaling

Oxidative phosphorylation

MYD88 distinct input-output pathway

Apoptosis modulation by HSP70

Prostaglandin synthesis and regulation

EGF/EGFR signaling pathway

Androgen receptor signaling pathway

Glycogen metabolism

Toll-like receptor signaling

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF/GATA4 signaling

Monoamine transport

DNA damage response

Sudden infant death syndrome (SIDS) susceptibility pathways

Methylation pathways

Ureide biosynthesis

Monoamine GPCRs

TGF-beta receptor signaling

Complement and coagulation cascades

ACE inhibitor pathway

IL23 inhibitors in inflammatory bowel disease

Biogenic amine synthesis

Complement and coagulation cascades

Complement activation

Glycolysis and gluconeogenesis

Cytokines and inflammatory response

Glucose metabolism in triple-negative breast cancer cells

Exercise and hypertrophy in skeletal muscle

Regulation of actin cytoskeleton

Pleural mesothelioma

Steroid biosynthesis

IL2 signaling

Ovarian infertility

Peptide GPCRs

B cell receptor signaling

Fatty acid omega-oxidation

miRNA regulation of DNA damage response

Physiological and pathological hypertrophy of the heart

Osteopontin signaling

Bone morphogenic protein signaling and regulation

AMP-activated protein kinase signaling

Glycogen metabolism

Notch signaling pathway

Glycogen metabolism

Androgen receptor signaling pathway

Glycogen metabolism

Notch signaling pathway

Alanine and aspartate metabolism

ID signaling pathway

Statin pathway

Notch signaling pathway

Insulin signaling

Cytoplasmic ribosomal proteins

Endochondral ossification

Tryptophan metabolism

Translation inhibitors in chronically activated PDGFRA cells

Neural crest cell migration in cancer

GPCRs, class A rhodopsin-like

G1 to S cell cycle control

Non-homologous end joining

EGF/EGFR signaling

Glycogen metabolism

Statin inhibition of cholesterol production

Hedgehog signaling

MAPK cascade

Endometrial cancer

mRNA processing

Exercise-induced circadian regulation

p38 MAPK signaling

H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer

TYROBP causal network in microglia

Microglia pathogen phagocytosis pathway

Apoptosis regulation by parathyroid hormone-related protein

Novel intracellular components of RIG-I-like receptor pathway

TLR4 signaling and tolerance

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer

MAPK signaling

lncRNA-mediated mechanisms of therapeutic resistance

Imatinib and chronic myeloid leukemia

Photodynamic therapy-induced NF-kB survival signaling

MicroRNA for targeting cancer growth and vascularization in glioblastoma

RAC1/PAK1/p38/MMP2 pathway

EV release from cardiac cells and their functional effects

Glycogen metabolism

Fas ligand pathway and stress induction of heat shock proteins

mRNA processing

Focal adhesion

Myometrial relaxation and contraction pathways

Extracellular vesicle-mediated signaling in recipient cells

TCA cycle nutrient use and invasiveness of ovarian cancer

Notch signaling

T cell receptor and co-stimulatory signaling

Apoptosis

Small ligand GPCRs

Retinoblastoma gene in cancer

Irinotecan pathway

IL17 signaling

Integrated cancer pathway

Cell cycle

Apoptosis modulation and signaling

Folate metabolism

TP53 network

Fluoropyrimidine activity

Glycolysis and gluconeogenesis

Biogenic amine synthesis

Angiogenesis

Selenium micronutrient network

Target of rapamycin signaling

Statin pathway

Fatty acid beta-oxidation

Androgen receptor signaling

Pentose phosphate metabolism

GPCRs, other

B cell receptor signaling pathway

Hedgehog signaling pathway

Androgen receptor signaling pathway

Kit receptor signaling pathway

Glutathione metabolism

Glycogen metabolism

Nuclear receptors

Nuclear receptors

Calcium regulation in cardiac cells

TCA cycle (aka Krebs or citric acid cycle)

Glutathione and one-carbon metabolism

DNA damage response (only ATM dependent)

Aflatoxin B1 metabolism

ErbB signaling

Integrin-mediated cell adhesion

Interferon type I signaling

Eukaryotic transcription initiation

Synthesis and degradation of ketone bodies

Calcium regulation in cardiac cells

DNA mismatch repair

G13 signaling

Nuclear Receptors

Oxidative stress and redox pathway

Epithelial to mesenchymal transition in colorectal cancer

Oxidative stress response

Eukaryotic transcription initiation

Clear cell renal cell carcinoma pathways

PDGFR-beta pathway

G protein signaling

Transcriptional activation by NRF2 in response to phytochemicals

Electron transport chain

Nuclear receptors

Homologous recombination

Integrin-mediated cell adhesion

Nuclear receptors

Energy metabolism

Electron transport chain

Homologous recombination

Nuclear receptors

Electron transport chain

Electron transport chain: OXPHOS system in mitochondria

Nuclear receptors

Electron transport chain

HDAC6 interactions in the central nervous system

Allograft rejection

IL5 signaling

Irinotecan pathway

Osteoclast signaling

Folate-alcohol and cancer pathway hypotheses

Vitamins A and D - action mechanisms

Lactate shuttle in glial cells

IL10 anti-inflammatory signaling

IL26 signaling

Nicotine metabolism in liver cells

Markers of kidney cell lineage

Affected pathways in Duchenne muscular dystrophy

eIF5A regulation in response to inhibition of the nuclear export system

Octadecanoid formation from linoleic acid

Omega-3-fatty acids in senescence

Metabolic reprogramming in colon cancer

Photodynamic therapy-induced AP-1 survival signaling

Serotonin HTR1 group and FOS pathway

Ergosterol biosynthesis

Cysteine biosynthesis from homoserine

Colanic acid building blocks biosynthesis

Molecular pathway for oxidative stress

Hallmark of cancer: metastasis and epithelial-to-mesenchymal transition

Fanconi anemia

Type I interferon induction and signaling during SARS-CoV-2 infection

Kallmann syndrome

Pantothenate and coenzyme A biosynthesis

Threonine biosynthesis

PCSK9-mediated LDL receptor degradation

Glutamate degradation I

Pyruvate dehydrogenase pathway

Dauer formation

Mitochondrial unfolded-protein response

ER stress-unfolded protein response (UPRer)

Heterochronic gene regulation of development

Ascaroside biosynthesis

TOR signaling

Cell division: first embryonic mitosis

Biogenic amine synthesis

Wnt signaling

Metapathway signal transduction

Principal pathways of carbon metabolism

T-cell activation SARS-CoV-2

Estradiol regulation in porto-sinusoidal vascular disease

Nonalcoholic fatty liver disease

Glucocorticoid receptor pathway

Endoplasmic reticulum stress response in coronavirus infection

Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex

GNAQ pathways in port-wine stain

Macrophage-stimulating protein (MSP) signaling

Activation of NLRP3 inflammasome by SARS-CoV-2

MAPK pathway in congenital thyroid cancer

Docosahexaenoic acid oxylipin metabolism

Major receptors targeted by epinephrine and norepinephrine

Metabolism of alpha-linolenic acid

Blood clotting and drug effects

Female steroid hormones in cardiomyocyte energy metabolism

DYRK1A involvement regarding cell proliferation in brain development

15q25 copy number variation

5q35 copy number variation

17p13.3 (YWHAE) copy number variation

Neurogenesis regulation in the olfactory epithelium

Hippocampal synaptogenesis and neurogenesis

ALA oxylipin metabolism

ACE2 inhibition leads to pulmonary fibrosis

p53 transcriptional gene network

EBV LMP1 signaling

Arachidonate epoxygenase / epoxide hydrolase

Exercise-induced circadian regulation

Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

8p23.1 copy number variation syndrome

1p36 copy number variation syndrome

Male steroid hormones in cardiomyocyte energy metabolism

Sebaleic acid formation and metabolism

Lacto series sphingolipid metabolism

Ganglio series sphingolipid metabolism

Pentose phosphate pathway in senescent cells

TCA cycle

Hijack of ubiquitination by SARS-CoV-2

ESC pluripotency pathways

Biotic stress response gene network

Dengue-2 interactions with complement and coagulation cascades

Nanomaterial-induced inflammasome activation

Quercetin and Nf-kB / AP-1 induced apoptosis

Folic acid network

Nod-like receptor (NLR) signaling pathway

Folic acid network

Nod-like receptor (NLR) signaling pathway

Complement and coagulation cascades

Nod-like receptor (NLR) signaling pathway

FTO obesity variant mechanism

Sulfur amino acid biosynthesis

Neurotransmitter release in cholinergic motor neurons

Sucrose biosynthesis

Hippo signaling regulation

CCL18 signaling

Nod-like receptor (NLR) signaling

Triacylglyceride synthesis

Sulfur degradation

Lipids measured in liver metastasis from breast cancer

Wnt signaling in kidney disease

Mecp2 and associated Rett syndrome

Extrafollicular and follicular B cell activation by SARS-CoV-2

mRNA vaccine activation of dendritic cell and induction of IFN-1

Poly(glycerol phosphate) wall teichoic acid biosynthesis

Hematopoietic stem cell differentiation

Mitochondrial complex inhibition leading to liver injury

Gastric acid production

Downregulation of ACE2 by SARS-CoV-2 spike protein

Ciliopathies

Envelope proteins and their potential roles in EDMD physiopathology

10q11.21q11.23 copy number variation syndrome

N-glycan biosynthesis

Flowering time pathway

Oxytocin signaling

Flowering time pathway

Thyroxine (thyroid hormone) production

Host-pathogen interaction of human coronaviruses - interferon induction

Angiotensin II receptor type 1 pathway

Evolocumab mechanism to reduce LDL cholesterol

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression

7-oxo-C and 7-beta-HC pathways

Oxysterols derived from cholesterol

Chronic hyperglycemia impairment of neuron function

Ether lipid biosynthesis

Hippo-Merlin signaling dysregulation

Codeine and morphine metabolism

KCNQ2-related epilepsies

Nucleotide GPCRs

Tryptophan metabolism

Notch signaling pathway

T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection

Canonical and non-canonical Notch signaling

Non-canonical Wnt pathway

Purine metabolism

Glycolysis in senescence

Primary ovarian insufficiency

Gibberellin A12 biosynthesis

CBD synthetic pathway

D-arginine and D-ornithine metabolism

Osteoblast signaling

Genetic alterations of lung cancer

Comprehensive IL-17A signaling

Mechanisms associated with pluripotency

Serotonin transporter activity

VEGFA-VEGFR2 signaling

Response regulator aspartate phosphatase interactions

Glucose homeostasis

Flower development

Elongation of (very) long chain fatty acids

Bacterial ceramide synthesis

Serotonin transporter activity

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF / GATA4 signaling

Serotonin receptor 2 and STAT3 signaling

Serotonin receptor 2 and STAT3 signaling

IL-9 signaling pathway

Amino acid conjugation of benzoic acid

IL-6 signaling pathway

Meiotic recombination genes

Osteoclast signaling

GPCRs, class A rhodopsin-like

Nuclear factor, erythroid-derived 2, like 2 signaling pathway

Metapathway biotransformation

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Mevalonate pathway

Glycerol teichoic acid biosynthesis

Catecholamine synthesis

Metabolism of tetrahydrocannabinol (THC)

Primary focal segmental glomerulosclerosis (FSGS)

Primary carbon metabolism

Carbon assimilation C4 pathway

Oxidation by cytochrome P450

Oxidation by cytochrome P450

mRNA processing

Heme biosynthesis

TCA cycle in senescence

Retinol metabolism

Retinol metabolism

Triacylglyceride synthesis

mRNA processing

Myometrial relaxation and contraction pathways

Myometrial relaxation and contraction pathways

Semaphorin interactions

mRNA processing

Myometrial relaxation and contraction pathways

mRNA processing

mRNA Processing

Retinoblastoma gene in cancer

Glycolysis and gluconeogenesis

Regulation of actin cytoskeleton

ID signaling pathway

ID signaling pathway

ID signaling pathway

ID signaling pathway

SARS-CoV-2 and COVID-19 pathway

BDNF pathway

Long-day flowering time pathway

Spinal cord injury

Nod-like receptor (NLR) signaling pathway

Role of carnosine in muscle contraction

Host-pathogen interaction of human coronaviruses - MAPK signaling

miR-222 in exercise-induced cardiac growth

Flowering time pathway

Nodal signaling pathway

Flavonoid pathway

Heterchronic control of molting

FGF signaling pathway

Folate biosynthesis

Wnt signaling pathway and pluripotency

EGFR1 signaling pathway

Exercise-induced circadian regulation

Canonical NF-kB pathway

Osteoclast signaling

Kit receptor signaling pathway

IL-6 signaling pathway

Aryl hydrocarbon receptor pathway

Delta-Notch signaling pathway

Neural crest differentiation

GPCRs, orphan

Endochondral ossification

Delta-Notch signaling pathway

Hedgehog signaling pathway

Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)

GPCRs, class C metabotropic glutamate, pheromone

Acrylamide biotransformation and exposure biomarkers

Tgif disruption of Shh signaling

GPCRs, class B secretin-like

Diclofenac metabolic pathway

SRF and miRs in smooth muscle differentiation and proliferation

Cytokines and inflammatory response

Methylation pathways

Nuclear receptors in lipid metabolism and toxicity

Delta-Notch signaling pathway

Hedgehog signaling pathway

Kit receptor signaling pathway

EGFR1 signaling pathway

Fatty acid omega-oxidation

Globo sphingolipid metabolism

Aryl hydrocarbon receptor

ATM signaling pathway

AMPK signaling

Folate-alcohol and cancer pathway

Isoprenoid precursor biosynthesis in Pf apicoplasts

NAD biosynthesis I from aspartate

Osteoblast signaling

Beta-alanine biosynthesis

Carotenoid biosynthesis

Ganglio sphingolipid metabolism

Statin pathway

Hedgehog signaling pathway

Kit receptor signaling pathway

Cytokines and inflammatory response

EGFR1 signaling pathway

Endochondral ossification

MAPK signaling pathway

Tryptophan degradation

Starch and cellulose biosynthesis

Inhibitor of DNA binding (ID) signaling pathway

Hedgehog signaling pathway

Kit receptor signaling pathway

Triacylglycerol biosynthesis

Biosynthesis of gamma-aminobutyric acid (GABA) by polyamine oxidation

Chlorophyll b degradation

Flower development: initiation

Delta-Notch signaling pathway

EGFR1 signaling pathway

Polyol pathway

GPR40 pathway

Nod-like receptor (NLR) signaling pathway

Hedgehog signaling pathway

Hedgehog signaling pathway

Osteoclast

Lipid droplet metabolism

Thick ascending limb transporters

Proximal tubule transporters

Glial cell differentiation

mir219 in oligodendrocyte differentiation and myelination

Kit receptor signaling pathway

Glycolysis and gluconeogenesis

Estrogen signaling

Biogenic amine synthesis

Microglia pathogen phagocytosis pathway

MicroRNAs in cardiomyocyte hypertrophy

p38 MAPK signaling pathway

p38 Mapk signaling pathway

Tyrobp causal network in microglia

Host-pathogen interaction of human coronaviruses - apoptosis

Host-pathogen interaction of human coronaviruses - autophagy

Toll-like receptor signaling

Wnt Signaling Pathway and Pluripotency

Ptf1a related regulatory pathway

Influenza A virus infection

Hexoses metabolism in proximal tubules

mir-193a and MVP in colon cancer metastasis

Transcriptional cascade regulating adipogenesis

Angiotensin II signaling (acute) in thick ascending limbs

Gonadotropin-releasing hormone (GnRH) signaling

Cocaine metabolism

Gluconeogenesis

Cadmium and glutathione

Fatty acid oxidation

PPAR signaling pathway

Lycopene biosynthesis

Arylamine metabolism

Estrogen signaling pathway

Acetaminophen synthesis

NAD salvage pathway III

NAD salvage pathway II

NAD salvage pathway I

Biosynthesis and regulation of nematode bile acids

Estrogen metabolism

Hfe effect on hepcidin production

Apoptosis

Brain derived neurotrophic factor

Hfe effect on hepcidin production

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Gene regulatory network modelling somitogenesis

Gastric cancer network 2

Glycolysis

Gene regulatory network modelling somitogenesis

Metapathway biotransformation

Histone modifications

Type II interferon signaling (IFNG)