Estrogen metabolism (WP1053)

Bos taurus

Authors

Alex Pico , Nuno , Egon Willighagen , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

C18-steroid hormone biosynthetic pathway

Participants

Label Type Compact URI Comment
2-Hydroxyestrone Metabolite hmdb:HMDB0000343
Estrone Metabolite hmdb:HMDB0000145
2-Hydroxyestradiol Metabolite hmdb:HMDB0000338
Estrone sulfate Metabolite hmdb:HMDB0001425
Oxygen Metabolite hmdb:HMDB0001377
Estrone-2,3-quinone Metabolite pubchem.compound:148381
16a-Hydroxyestrone Metabolite hmdb:HMDB0000335
2-Methoxyestrone 3-glucuronide Metabolite hmdb:HMDB0004482
Estradiol-3-glucuronide Metabolite hmdb:HMDB0006224
Superoxide Metabolite hmdb:HMDB0002168
2-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-17-glucuronide Metabolite hmdb:HMDB0004483
4-Methoxyestradiol Metabolite hmdb:HMDB0000405
Estrone-3-glucuronide Metabolite hmdb:HMDB0004483
2-Methoxyestrone Metabolite hmdb:HMDB0000010
Estrone-3,4-quinone Metabolite pubchem.compound:114862
COMT GeneProduct ensembl:ENSBTAG00000019516 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000093010
CYP1A2 GeneProduct ensembl:ENSBTAG00000000085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
UGT1A1 GeneProduct ensembl:ENSBTAG00000026181 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54658
SULT1E1 GeneProduct ensembl:ENSBTAG00000011952 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109193
SULT1A1 GeneProduct ensembl:ENSBTAG00000008635 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196502
ARSE GeneProduct ensembl:ENSBTAG00000014932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157399
UGT2B7 GeneProduct ensembl:ENSBTAG00000040337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171234
NQO1 GeneProduct ensembl:ENSBTAG00000020632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181019
CYP3A4 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP1A1 GeneProduct ensembl:ENSBTAG00000001021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243955
UGT1A3 GeneProduct ensembl:ENSBTAG00000048275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54659
STS GeneProduct ensembl:ENSBTAG00000020789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:412
CYP1B1 GeneProduct ensembl:ENSBTAG00000010531 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061

References

  1. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937–42. PubMed Europe PMC Scholia
  2. Estrogen metabolism by conjugation. Raftogianis R, Creveling C, Weinshilboum R, Weisz J. J Natl Cancer Inst Monogr. 2000;(27):113–24. PubMed Europe PMC Scholia
  3. 2-Methoxyestradiol, a promising anticancer agent. Lakhani NJ, Sarkar MA, Venitz J, Figg WD. Pharmacotherapy. 2003 Feb;23(2):165–72. PubMed Europe PMC Scholia
  4. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM. Mol Endocrinol. 2003 Jul;17(7):1344–55. PubMed Europe PMC Scholia
  5. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, et al. Carcinogenesis. 2003 Apr;24(4):697–702. PubMed Europe PMC Scholia
  6. Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Guillemette C, Bélanger A, Lépine J. Breast Cancer Res. 2004;6(6):246–54. PubMed Europe PMC Scholia
  7. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Abel EL, Lyon RP, Bammler TK, Verlinde CLMJ, Lau SS, Monks TJ, et al. Chem Biol Interact. 2004 Dec 30;151(1):21–32. PubMed Europe PMC Scholia
  8. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL. Breast Cancer Res. 2005;7(6):R909-21. PubMed Europe PMC Scholia