Transcriptional cascade regulating adipogenesis (WP4211)

Homo sapiens

Peroxisome proliferator-activated receptor gamma (PPARG) lies at the core of the transcriptional cascade that regulates adipogenesis. The expression of PPARG is regulated by several pro-adipogenic (green) and anti-adipogenic (orange) factors. PPARG itself is activated by an as-yet-uncharacterized ligand. CCAAT-enhancer-binding protein alpha (C/EBPA) is regulated through a series of inhibitory protein–protein interactions. Some transcription-factor families have several members that participate in adipogenesis, such as the Krüppel-like factors (KLFs). Rosen et al. Figure 2a


Martina Summer-Kutmon and Alex Pico


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Homo sapiens



Cell Type Ontology

fat cell

Pathway Ontology

signaling pathway pertinent to development


Label Type Compact URI Comment
GATA2 GeneProduct ensembl:ENSG00000179348 GATA2/3
GATA3 GeneProduct ensembl:ENSG00000107485 GATA2/3
CEBPA GeneProduct ensembl:ENSG00000245848 C/EBPα
CEBPG GeneProduct ensembl:ENSG00000153879 C/EBPγ
KLF5 GeneProduct ensembl:ENSG00000102554
SREBF1 GeneProduct ensembl:ENSG00000072310 SREBP1c
CEBPD GeneProduct ensembl:ENSG00000221869 C/EBPδ
CEBPB GeneProduct ensembl:ENSG00000172216 C/EBPβ
PPARG GeneProduct ensembl:ENSG00000132170 PPARγ
KLF2 GeneProduct ensembl:ENSG00000127528
EGR2 GeneProduct ensembl:ENSG00000122877 KROX20
DDIT3 GeneProduct ensembl:ENSG00000175197 CHOP
KLF15 GeneProduct ensembl:ENSG00000163884


  1. Adipocyte differentiation from the inside out. Rosen ED, MacDougald OA. Nat Rev Mol Cell Biol. 2006 Dec;7(12):885–96. PubMed Europe PMC Scholia