Macrophage markers (WP4146)
Overview of macrophage markers. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes. Based on [http://www.antibodybeyond.com/reviews/cell-markers/macrophage-marker.htm this list] and tissue-specific gene expression from [http://biogps.org/ GeneAtlas]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4146 CPTAC Assay Portal]
AuthorsMartina Summer-Kutmon , Kristina Hanspers , and Alex Pico
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- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
- Identification of high‐dimensional omics‐derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling (2021).
- Identification of potential drug targets for vascular dementia and carotid plaques by analyzing underlying molecular signatures shared by them (2022).
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Cell Type Ontologymacrophage
|CD14||GeneProduct||ensembl:ENSG00000170458||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12475|
|CD83||GeneProduct||ensembl:ENSG00000112149||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12522|
|CD68||GeneProduct||ensembl:ENSG00000129226||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12514|
|F3||GeneProduct||ensembl:ENSG00000117525||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14066|
|CD163||GeneProduct||ensembl:ENSG00000177575||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93671|
|CD86||GeneProduct||ensembl:ENSG00000114013||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12524|
|CD74||GeneProduct||ensembl:ENSG00000019582||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16149|
|RAC2||GeneProduct||ensembl:ENSG00000128340||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19354|
|LYZ||GeneProduct||ensembl:ENSG00000090382||Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17105|
- CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide. Mahnke K, Becher E, Ricciardi-Castagnoli P, Luger TA, Schwarz T, Grabbe S. Adv Exp Med Biol. 1997;417:145–59. PubMed Europe PMC Scholia
- Synergistic effects of colony-stimulating factor 1 and leukemia inhibitory factor in inducing early myeloid cell differentiation. Aperlo C, Sevilla L, Guerin S, Pognonec P, Boulukos KE. Cell Growth Differ. 1998 Nov;9(11):929–37. PubMed Europe PMC Scholia
- Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments. Fonseca JE, Edwards JCW, Blades S, Goulding NJ. Arthritis Rheum. 2002 May;46(5):1210–6. PubMed Europe PMC Scholia
- The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b. Brettschneider J, Ecker D, Bitsch A, Bahner D, Bogumil T, Dressel A, et al. J Neuroimmunol. 2002 Dec;133(1–2):193–7. PubMed Europe PMC Scholia
- CD163: a specific marker of macrophages in paraffin-embedded tissue samples. Lau SK, Chu PG, Weiss LM. Am J Clin Pathol. 2004 Nov;122(5):794–801. PubMed Europe PMC Scholia
- Expression of CD163 in the liver of patients with viral hepatitis. Hiraoka A, Horiike N, Akbar SMF, Michitaka K, Matsuyama T, Onji M. Pathol Res Pract. 2005;201(5):379–84. PubMed Europe PMC Scholia
- Identification of factor XIII-A as a marker of alternative macrophage activation. Töröcsik D, Bárdos H, Nagy L, Adány R. Cell Mol Life Sci. 2005 Sep;62(18):2132–9. PubMed Europe PMC Scholia
- The “classical” macrophage marker CD68 is strongly expressed in primary human fibroblasts. Kunz-Schughart LA, Weber A, Rehli M, Gottfried E, Brockhoff G, Krause SW, et al. Verh Dtsch Ges Pathol. 2003;87:215–23. PubMed Europe PMC Scholia