Genetic alterations of lung cancer (WP1968)

Rattus norvegicus

Expression patterns of two major tumor suppressor pathways in lung cancer. These pathways are functionally linked to lung cancer and play role as a component of checkpoints and growth inhibitory pathways. Components which/who are activated in this pathway are Egfr, Erbb2, Rasl11b, and MYC in the Oncogenic singalling part. Frequent inactivated are TGF-beta R1/2, RB, p16INK4A, Tp53, and p14ARF, whie infrequent inactivated are Smad2 and Sma4. Both, the p14ARF/p53 and the p16INK4A/RB pathway lead to cell cycle arrest.


Gustav , Kristina Hanspers , Martina Summer-Kutmon , Christine Chichester , Jonathan Mélius , Alex Pico , Egon Willighagen , Friederike Ehrhart , Lauren J. Dupuis , and Marvin Martens


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Rattus norvegicus



Pathway Ontology

cancer pathway lung cancer pathway

Disease Ontology

lung cancer


Label Type Compact URI Comment
Pik3ca GeneProduct ensembl:ENSRNOG00000056371
Erbb2 GeneProduct ensembl:ENSRNOG00000006450
Egfr GeneProduct ensembl:ENSRNOG00000004332
ERK GeneProduct ensembl:ENSRNOG00000001849
Map2k1 GeneProduct ensembl:ENSRNOG00000010176
Raf1 GeneProduct ensembl:ENSRNOG00000010153
Rasl11b GeneProduct ensembl:ENSRNOG00000002097
Akt1 GeneProduct ensembl:ENSRNOG00000028629
MYC GeneProduct ensembl:ENSRNOG00000042556
Tgfb1 GeneProduct ensembl:ENSRNOG00000020652
Smad4 GeneProduct ensembl:ENSRNOG00000051965
Smad2 GeneProduct ensembl:ENSRNOG00000018140
TGF-beta R1/2 GeneProduct ensembl:ENSRNOG00000002418
Ccnd1 GeneProduct ensembl:ENSRNOG00000020918
Cdk4 GeneProduct ensembl:ENSRNOG00000025602
RB GeneProduct ensembl:ENSRNOG00000016029
E2F GeneProduct ensembl:ENSRNOG00000016708
Dmp1 GeneProduct ensembl:ENSRNOG00000002167
Mdm2 GeneProduct ensembl:ENSRNOG00000006304
CBP GeneProduct ensembl:ENSRNOG00000005330
Tp53 GeneProduct ensembl:ENSRNOG00000010756
Atm GeneProduct ensembl:ENSRNOG00000029773
p300 GeneProduct ensembl:ENSRNOG00000000190
Ccne1 GeneProduct ensembl:ENSRNOG00000014786
Cdk2 GeneProduct ensembl:ENSRNOG00000006469
p21 GeneProduct ensembl:ENSRNOG00000000521
Pik3cd GeneProduct ensembl:ENSRNOG00000016846


  1. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, et al. Genes Dev. 1998 Aug 1;12(15):2424–33. PubMed Europe PMC Scholia
  2. Repression of p15INK4b expression by Myc through association with Miz-1. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, et al. Nat Cell Biol. 2001 Apr;3(4):392–9. PubMed Europe PMC Scholia
  3. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. Nat Cell Biol. 2001 Nov;3(11):973–82. PubMed Europe PMC Scholia
  4. Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Osada H, Takahashi T. Oncogene. 2002 Oct 21;21(48):7421–34. PubMed Europe PMC Scholia