Semaphorin interactions (WP3151)

Bos taurus

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=373755

Authors

Martina Summer-Kutmon , Linda Rieswijk , and Alex Pico

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

signaling pathway

Participants

Label Type Compact URI Comment
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
GTP [cytosol] Metabolite chebi:15996
GDP [plasmamembrane] Metabolite chebi:17552
GTP Metabolite chebi:15996
GDP Metabolite chebi:17552
GTP [plasmamembrane] Metabolite chebi:15996
Pi Metabolite chebi:18367
Mg2+ [plasmamembrane] Metabolite chebi:18420
GDP [cytosol] Metabolite chebi:17552
SEMA4D Protein ensembl:ENSBTAG00000001941 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92854
ERBB2 Protein ensembl:ENSBTAG00000021798 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P04626
PLXNB1 Protein ensembl:ENSBTAG00000013407 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O43157
RND1 Protein ensembl:ENSBTAG00000018773 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92730
ARHGEF11 Protein ensembl:ENSBTAG00000012361 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15085
ARHGEF12 Protein ensembl:ENSBTAG00000021343 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9NZN5
RHOA Protein ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P61586
RHOB Protein ensembl:ENSBTAG00000046054 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P62745
RHOC Protein ensembl:ENSBTAG00000014299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08134
ROCK1 Protein ensembl:ENSBTAG00000008403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13464
ROCK2 Protein ensembl:ENSBTAG00000005847 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O75116
MYH10 Protein ensembl:ENSBTAG00000021151 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P35580
MYH14 Protein ensembl:ENSBTAG00000002580 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q7Z406
MYH9 Protein ensembl:ENSBTAG00000010402 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P35579
MYH11 Protein ensembl:ENSBTAG00000015988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P35749
MYL6 Protein ensembl:ENSBTAG00000010799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P60660
MYL9 Protein ensembl:ENSBTAG00000011473 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P24844
MYL12B Protein ensembl:ENSBTAG00000026266 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14950
C-MET Protein ensembl:ENSBTAG00000006161 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08581
RAC1 Protein ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P63000
RRAS Protein ensembl:ENSBTAG00000020983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10301
ARHGAP35 Protein ensembl:ENSBTAG00000015543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9NRY4
PLXNA1 Protein ensembl:ENSBTAG00000009159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9UIW2
PLXNA2 Protein ensembl:ENSBTAG00000001173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O75051
PLXNA3 Protein ensembl:ENSBTAG00000008552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51805
PLEX2 Protein ensembl:ENSBTAG00000014543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9HCM2
FYN Protein ensembl:ENSBTAG00000011851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P06241
NRP1 Protein ensembl:ENSBTAG00000019866 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14786
SEMA3A Protein ensembl:ENSBTAG00000018133 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q14563
FES Protein ensembl:ENSBTAG00000002941 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P07332
PIP5K1C Protein ensembl:ENSBTAG00000000710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O60331
TLN1 Protein ensembl:ENSBTAG00000025868 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y490
PAK1 Protein ensembl:ENSBTAG00000010191 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13153
PAK2 Protein ensembl:ENSBTAG00000047856 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13177
LIMK1 Protein ensembl:ENSBTAG00000044083 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53667
HSP90AA1 Protein ensembl:ENSBTAG00000006270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P07900
HSP90AB1 Protein ensembl:ENSBTAG00000047699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08238
CFL1 Protein ensembl:ENSBTAG00000021455 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P23528
CDK5 Protein ensembl:ENSBTAG00000007766 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q00535
CDK5R1 Protein ensembl:ENSBTAG00000004475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15078
CRMP1 Protein ensembl:ENSBTAG00000004292 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q14194
DPYSL2 Protein ensembl:ENSBTAG00000018373 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q16555
DPYSL3 Protein ensembl:ENSBTAG00000010661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q14195
DPYSL4 Protein ensembl:ENSBTAG00000017780 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14531
DPYSL5 Protein ensembl:ENSBTAG00000018576 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9BPU6
DPYSL4 Protein ensembl:ENSBTAG00000017780 CRMP-3 does not have the conserved serine 522 and based on similarity serine 544 may be phosphorylated upon sema3A stimulation.
HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14531
CD72 Protein ensembl:ENSBTAG00000011409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21854
PTPRC Protein ensembl:ENSBTAG00000023144 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08575
PLXND1 Protein ensembl:ENSBTAG00000001814 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y4D7
SEMA3E Protein ensembl:ENSBTAG00000014920 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15041
SEMA4A Protein ensembl:ENSBTAG00000012228 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9H3S1
PLXNB3 Protein ensembl:ENSBTAG00000010146 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9ULL4
SEMA5A Protein ensembl:ENSBTAG00000005021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13591
SEMA6A Protein ensembl:ENSBTAG00000020489 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9H2E6
TREM2 Protein ensembl:ENSBTAG00000007275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9NZC2
TYROBP Protein ensembl:ENSBTAG00000007338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O43914
SEMA6D Protein ensembl:ENSBTAG00000016800 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8NFY4
SEMA7A Protein ensembl:ENSBTAG00000011446 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O75326
PLXNC1 Protein ensembl:ENSBTAG00000011245 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O60486
ITGB1 Protein ensembl:ENSBTAG00000015910 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P05556
ITGA1 Protein ensembl:ENSBTAG00000016525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P56199
GSK3B Protein ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49841

References

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  2. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, et al. EMBO J. 1996 Apr 15;15(8):1885–93. PubMed Europe PMC Scholia
  3. CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion. Herold C, Elhabazi A, Bismuth G, Bensussan A, Boumsell L. J Immunol. 1996 Dec 15;157(12):5262–8. PubMed Europe PMC Scholia
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  5. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, et al. Cell. 1999 Oct 1;99(1):71–80. PubMed Europe PMC Scholia
  6. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Edwards DC, Sanders LC, Bokoch GM, Gill GN. Nat Cell Biol. 1999 Sep;1(5):253–9. PubMed Europe PMC Scholia
  7. Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage. Billard C, Delaire S, Raffoux E, Bensussan A, Boumsell L. Blood. 2000 Feb 1;95(3):965–72. PubMed Europe PMC Scholia
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  10. Molecular basis of semaphorin-mediated axon guidance. Nakamura F, Kalb RG, Strittmatter SM. J Neurobiol. 2000 Aug;44(2):219–29. PubMed Europe PMC Scholia
  11. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. Sumi T, Matsumoto K, Nakamura T. J Biol Chem. 2001 Jan 5;276(1):670–6. PubMed Europe PMC Scholia
  12. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Vikis HG, Li W, He Z, Guan KL. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12457–62. PubMed Europe PMC Scholia
  13. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, et al. Immunity. 2000 Nov;13(5):621–31. PubMed Europe PMC Scholia
  14. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, et al. Nat Neurosci. 2001 Apr;4(4):367–73. PubMed Europe PMC Scholia
  15. The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. Chong C, Tan L, Lim L, Manser E. J Biol Chem. 2001 May 18;276(20):17347–53. PubMed Europe PMC Scholia
  16. Plexin signaling via off-track and rho family GTPases. Whitford KL, Ghosh A. Neuron. 2001 Oct 11;32(1):1–3. PubMed Europe PMC Scholia
  17. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Vikis HG, Li W, Guan KL. Genes Dev. 2002 Apr 1;16(7):836–45. PubMed Europe PMC Scholia
  18. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S. EMBO J. 2002 Jul 1;21(13):3274–85. PubMed Europe PMC Scholia
  19. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12085–90. PubMed Europe PMC Scholia
  20. The semaphorin 4D receptor controls invasive growth by coupling with Met. Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, et al. Nat Cell Biol. 2002 Sep;4(9):720–4. PubMed Europe PMC Scholia
  21. Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, et al. Biochem Biophys Res Commun. 2002 Sep 13;297(1):32–7. PubMed Europe PMC Scholia
  22. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, et al. Neuron. 2002 Aug 29;35(5):907–20. PubMed Europe PMC Scholia
  23. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Nature. 2002 Nov 7;420(6911):89–93. PubMed Europe PMC Scholia
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  26. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. Oinuma I, Katoh H, Harada A, Negishi M. J Biol Chem. 2003 Jul 11;278(28):25671–7. PubMed Europe PMC Scholia
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  43. Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1. Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, et al. EMBO J. 2007 Mar 7;26(5):1373–84. PubMed Europe PMC Scholia
  44. The CRMP family of proteins and their role in Sema3A signaling. Schmidt EF, Strittmatter SM. Adv Exp Med Biol. 2007;600:1–11. PubMed Europe PMC Scholia
  45. Intracellular kinases in semaphorin signaling. Ahmed A, Eickholt BJ. Adv Exp Med Biol. 2007;600:24–37. PubMed Europe PMC Scholia
  46. ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1. Swiercz JM, Worzfeld T, Offermanns S. J Biol Chem. 2008 Jan 25;283(4):1893–901. PubMed Europe PMC Scholia
  47. Role of semaphorins during axon growth and guidance. Koncina E, Roth L, Gonthier B, Bagnard D. Adv Exp Med Biol. 2007;621:50–64. PubMed Europe PMC Scholia
  48. Semaphorin signaling: progress made and promises ahead. Zhou Y, Gunput RAF, Pasterkamp RJ. Trends Biochem Sci. 2008 Apr;33(4):161–70. PubMed Europe PMC Scholia