Histidine metabolism (WP1581)

Mycobacterium tuberculosis

Source: [http://www.genome.jp/kegg-bin/show_pathway?mtu00340 KEGG Pathways] Mycobacterium tuberculosis is an obligate pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. This coating makes the cells impervious to Gram staining, and as a result, M. tuberculosis can appear either Gram-negative or Gram-positive. Several of the proteins needed for hystidine metabolism are not present in Mycobacterium tuberculosis, resulting in incomplete knowledge on the formation of for example imidazole-4-acetaldehyde and N-methylhistamine.


Kristina Hanspers , Allan Kuchinsky , Alex Pico , Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , and Denise Slenter


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Mycobacterium tuberculosis



Pathway Ontology

histidine metabolic pathway tuberculosis pathway


Label Type Compact URI Comment
L-histidinol Metabolite kegg.compound:C00860
Methylimidazole acetaldehyde Metabolite kegg.compound:C05827
Imidazole-4-acetaldehyde Metabolite kegg.compound:C05130
Ergothioneine Metabolite kegg.compound:C05570
Hercynine Metabolite kegg.compound:C05575
L-histidinal Metabolite kegg.compound:C01929
Phosphoribosyl-AMP Metabolite kegg.compound:C02741
S-(Hercyn-2-yl)-L-cysteine S-oxide Metabolite kegg.compound:C20994
gamma-L-Glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide Metabolite kegg.compound:C20995
L-Histidine Metabolite kegg.compound:C00135
Phosphoribosyl-formimino-AICAR-phosphate Metabolite kegg.compound:C04896
N-Methylhistamine Metabolite kegg.compound:C05127
Phosphoribulosyl-formimino-AICAR-phosphate Metabolite kegg.compound:C04916
Imidazole-acetol phosphate Metabolite kegg.compound:C01267
D-erythro-Imidazole-glycerol phosphate Metabolite kegg.compound:C04666
L-histidinol-P Metabolite kegg.compound:C01100
5-Phosphoribosyl diphosphate Metabolite kegg.compound:C00119
Phosphoribosyl-ATP Metabolite kegg.compound:C02739
Imidazole-4-acetate Metabolite kegg.compound:C02835
Thiourocanic acid Metabolite kegg.compound:C05571
aldehyde dehydrogenase (NAD+) GeneProduct eccode: Original kegg element: gene;19;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
histidinol-phosphatase GeneProduct eccode:
hisF GeneProduct uniprot:I6XYE3 Original kegg element: gene;36;mtu:Rv1605
hisC1 GeneProduct uniprot:I6XYD8 Original kegg element: gene;29;mtu:Rv1600 mtu:Rv3772
hisA GeneProduct eccode: Original kegg element: gene;32;mtu:Rv1603
hisC2 GeneProduct uniprot:I6Y4H4 Original kegg element: gene;29;mtu:Rv1600 mtu:Rv3772
hisE GeneProduct eccode: Original kegg element: gene;34;mtu:Rv2122c
hisB GeneProduct myco.tuber:Rv1601 Original kegg element: gene;30;mtu:Rv1601
hisD GeneProduct eccode: Original kegg element: gene;27;mtu:Rv1599
aofH GeneProduct eccode: Original kegg element: gene;20;mtu:Rv3170
hisH GeneProduct uniprot:I6YB19 Original kegg element: gene;91;mtu:Rv1602
hisG GeneProduct eccode: Original kegg element: gene;25;mtu:Rv2121c
hisI GeneProduct eccode: Original kegg element: gene;33;mtu:Rv1606
L-histidine N alpha-methyltransferase Protein eccode:
gamma-glutamyl hercynylcysteine S-oxide synthase Protein eccode:1.1.499.50
hercynylcysteine S-oxide lyase Protein eccode:
gamma-glutamyl hercynylcysteine S-oxide hydrolase Protein eccode:
CobC Protein uniprot:P9WQ89