Glutamate degradation I (WP556)

Saccharomyces cerevisiae

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In S. cerevisiae, the main pathway for glutamate degradation is catalyzed by the glutamate dehydrogenase encoded by GDH2 (https://www.wikipathways.org/pathways/WP503.html). However, glutamate can also by degraded into gamma-aminobutyrate (GABA) by the glutamate decarboxylase Gad1p and then converted into succinate by the enzymes encoded by UGA1 and UGA2. Based on Yeast Pathways https://pathway.yeastgenome.org/.

Authors

Jessica Heckman , Alex Pico , Christine Chichester , Egon Willighagen , Tim Verbruggen , and Kristina Hanspers

Activity

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

glutamate degradation pathway I

Participants

Label Type Compact URI Comment
H2O Metabolite chebi:15377
L-glutamate Metabolite chebi:29985
succinate semialdehyde Metabolite chebi:57706
CO2 Metabolite hmdb:HMDB01967
2-oxoglutarate Metabolite chebi:16810
NAD(P)H Metabolite chebi:13392
4-aminobutanoate Metabolite chebi:59888
succinate Metabolite chebi:30031
NAD(P)+ Metabolite chebi:13390
H+ Metabolite hmdb:HMDB59597
UGA2 GeneProduct ensembl:YBR006W
GAD1 GeneProduct sgd:S000004862
UGA1 GeneProduct ensembl:YGR019W

References

  1. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=GLUDEG-I-PWY-1