Ptf1a related regulatory pathway (WP201)

Mus musculus

By summarizing published data together with our own results, this pathway shows a complicated relationships between transcriptional factors, miRNAs and some functional genes which are correlated together to generate a whole sight in early mouse development centered around Ptf1a, although there are some hypothetical relationships and the distinct development of dorsal and ventral pancreas in very early stage is neglected.


Yang an , Thomas Kelder , Alex Pico , Kristina Hanspers , Daniela Digles , Egon Willighagen , and Lauren J. Dupuis


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Mus musculus



Pathway Ontology

transcription factor mediated signaling pathway


Label Type Compact Identifier Comment
Pdx1 GeneProduct ensembl:ENSMUSG00000029644
Rbpj GeneProduct ensembl:ENSMUSG00000039191
Nkx6-1 GeneProduct ensembl:ENSMUSG00000035187
Ctnnb1 GeneProduct ensembl:ENSMUSG00000006932
Hes1 GeneProduct mgi:MGI:104853
Prox1 GeneProduct ensembl:ENSMUSG00000010175
Rbpj GeneProduct ensembl:ENSMUSG00000039191
Notch1 GeneProduct ensembl:ENSMUSG00000026923
Fgf10 GeneProduct ensembl:ENSMUSG00000021732
Kat2b GeneProduct ensembl:ENSMUSG00000000708
Rbpjl GeneProduct ensembl:ENSMUSG00000017007
Ptf1a GeneProduct ensembl:ENSMUSG00000026735
Pdx1 Protein ensembl:ENSMUSG00000029644


  1. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI. J Histochem Cytochem. 1998 Jun;46(6):707–15. PubMed Europe PMC Scholia
  2. Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1. Watada H, Mirmira RG, Leung J, German MS. J Biol Chem. 2000 Nov 3;275(44):34224–30. PubMed Europe PMC Scholia
  3. Prox1 activity controls pancreas morphogenesis and participates in the production of “secondary transition” pancreatic endocrine cells. Wang J, Kilic G, Aydin M, Burke Z, Oliver G, Sosa-Pineda B. Dev Biol. 2005 Oct 1;286(1):182–94. PubMed Europe PMC Scholia
  4. Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex. Ghosh B, Leach SD. Biochem J. 2006 Feb 1;393(Pt 3):679–85. PubMed Europe PMC Scholia
  5. An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Jacquemin P, Yoshitomi H, Kashima Y, Rousseau GG, Lemaigre FP, Zaret KS. Dev Biol. 2006 Feb 1;290(1):189–99. PubMed Europe PMC Scholia
  6. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, et al. BMC Dev Biol. 2007 Jan 12;7:4. PubMed Europe PMC Scholia
  7. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, et al. Mol Cell Biol. 2007 Jun;27(11):4093–104. PubMed Europe PMC Scholia
  8. Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III. Miyatsuka T, Matsuoka T aki, Shiraiwa T, Yamamoto T, Kojima I, Kaneto H. Biochem Biophys Res Commun. 2007 Nov 3;362(4):905–9. PubMed Europe PMC Scholia
  9. Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development. Fujikura J, Hosoda K, Kawaguchi Y, Noguchi M, Iwakura H, Odori S, et al. Dev Dyn. 2007 Oct;236(10):2779–91. PubMed Europe PMC Scholia
  10. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ. Genes Dev. 2007 Oct 15;21(20):2629–43. PubMed Europe PMC Scholia
  11. Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Dong PDS, Provost E, Leach SD, Stainier DYR. Genes Dev. 2008 Jun 1;22(11):1445–50. PubMed Europe PMC Scholia
  12. p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation. Rodolosse A, Campos ML, Rooman I, Lichtenstein M, Real FX. Biochem J. 2009 Mar 1;418(2):463–73. PubMed Europe PMC Scholia