Alanine and aspartate metabolism (WP106)
Homo sapiens
Converted from rat to human using ortholog information, originally from KEGG. Originally edited by Sebastien Burel. This pathway describes the metabolism of amino acids alanine and aspartate. Alanine is broken down by oxidative deamination, the inverse reaction of the reductive amination biosynthesis, catalyzed by the same enzymes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP106 CPTAC Assay Portal]
Authors
Lynn M. Ferrante , Kristina Hanspers , Andra Waagmeester , Michiel Adriaens , Martijn Van Iersel , Alex Pico , Christine Chichester , Egon Willighagen , Martina Summer-Kutmon , and Daniela DiglesActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
amino acid metabolic pathway alanine, aspartate and glutamate metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Pyruvate | Metabolite | chebi:32816 | |
| L-Alanine | Metabolite | chebi:16977 | |
| N-Carbamoyl-L-aspartate | Metabolite | chebi:15859 | |
| D-Alanine | Metabolite | cas:338-69-2 | D-Alanine |
| b-Alanine | Metabolite | chebi:16958 | beta-alanine |
| L-Asparagine acid | Metabolite | cas:70-47-3 | |
| Acetyl-CoA | Metabolite | cas:72-89-9 | Acetyl-CoA |
| L-Aspartic acid | Metabolite | kegg.compound:C00049 | |
| N-Acetyl-L-aspartate | Metabolite | wikidata:Q28000013 | |
| Malate | Metabolite | cas:6915-15-7 | (S)-Malate |
| Succinate | Metabolite | kegg.compound:C00042 | |
| Malonate semialdehyde | Metabolite | chebi:33190 | |
| Citric acid | Metabolite | hmdb:HMDB0000094 | |
| L-Asparagine acid | Metabolite | cas:70-47-3 | |
| Adenylosuccinate | Metabolite | chebi:15919 | |
| Oxaloacetate | Metabolite | kegg.compound:C00036 | |
| L-Asparagine | Metabolite | cas:70-47-3 | L-Asparagine |
| 2-Oxoglutarate | Metabolite | kegg.compound:C00026 | |
| O-Acetylcarnitine | Metabolite | cas:3040-38-8 | |
| Carnosine | Metabolite | cas:305-84-0 | Carnosine |
| D-aspartate | Metabolite | kegg.compound:C00402 | |
| Fumarate | Metabolite | kegg.compound:C00122 | |
| L-aspartate | Metabolite | kegg.compound:C00049 | |
| 2-Oxosuccinamate | Metabolite | chebi:57735 | |
| L-Argininosuccinate | Metabolite | chebi:15682 | |
| 3.5.1.3 | GeneProduct | eccode:3.5.1.3 | |
| GOT2 | GeneProduct | ncbigene:2806 | |
| 3.4.13.3 | GeneProduct | eccode:3.4.13.3 | |
| ASL | GeneProduct | ncbigene:435 | |
| ABAT | GeneProduct | ncbigene:18 | |
| 4.1.1.11 | GeneProduct | eccode:4.1.1.11 | |
| 1.4.3.2 | GeneProduct | eccode:1.4.3.2 | |
| 4.1.1.12 | GeneProduct | eccode:4.1.1.12 | |
| DARS | GeneProduct | ncbigene:1615 | |
| ASPA | GeneProduct | ncbigene:443 | |
| 5.1.1.1 | GeneProduct | eccode:5.1.1.1 | |
| 2.6.1.12 | GeneProduct | eccode:2.6.1.12 | |
| DARS | GeneProduct | ncbigene:1615 | |
| AGXT | GeneProduct | ncbigene:189 | |
| 6.3.1.1 | GeneProduct | eccode:6.3.1.1 | |
| 1.2.1.18 | GeneProduct | eccode:1.2.1.18 | |
| 5.1.1.13 | GeneProduct | eccode:5.1.1.13 | |
| GPT | GeneProduct | ncbigene:2875 | |
| 3.5.1.7 | GeneProduct | eccode:3.5.1.7 | |
| 6.3.5.6 | GeneProduct | eccode:6.3.5.6 | |
| 3.5.1.38 | GeneProduct | eccode:3.5.1.38 | |
| 4.3.1.1 | GeneProduct | eccode:4.3.1.1 | |
| 2.3.1.7 | GeneProduct | eccode:2.3.1.7 | |
| 1.4.3.15 | GeneProduct | eccode:1.4.3.15 | |
| 3.5.1.1 | GeneProduct | eccode:3.5.1.1 | |
| 6.3.2.11 | GeneProduct | eccode:6.3.2.11 | |
| 1.4.3.16 | GeneProduct | eccode:1.4.3.16 | |
| 6.1.1.22 | GeneProduct | eccode:6.1.1.22 | |
| 2.6.1.18 | GeneProduct | eccode:2.6.1.18 | |
| 2.6.1.14 | GeneProduct | eccode:2.6.1.14 | |
| 6.1.1.7 | GeneProduct | eccode:6.1.1.7 | |
| GAD2 | GeneProduct | ncbigene:2572 | |
| GAD1 | GeneProduct | ncbigene:2571 | |
| 1.4.3.1 | GeneProduct | eccode:1.4.3.1 | |
| ASS | GeneProduct | ncbigene:445 | |
| 6.3.4.4 | GeneProduct | eccode:6.3.4.4 | |
| 2.1.3.2 | GeneProduct | eccode:2.1.3.2 | |
| 4.3.2.2 | GeneProduct | eccode:4.3.2.2 | |
| PC | GeneProduct | ncbigene:5091 | |
| GOT1 | GeneProduct | ncbigene:2805 | |
| 6.3.5.4 | GeneProduct | eccode:6.3.5.4 |
References
- Intestinal mucosal amino acid catabolism. Wu G. J Nutr. 1998 Aug;128(8):1249–52. PubMed Europe PMC Scholia
- Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters. Curien G, Bastien O, Robert-Genthon M, Cornish-Bowden A, Cárdenas ML, Dumas R. Mol Syst Biol. 2009;5:271. PubMed Europe PMC Scholia