Benzo(a)pyrene metabolism (WP696)

Homo sapiens

Benzene metabolism primarily takes place in the liver, to a variety of products that are transported to the bone marrow where additional metabolism occurs. Several metabolites of benzene are responsible for the toxic effects of benzene including reactive metabolites that covalently bind macromolecules and induce oxidative damage. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Pieter Giesbertz , Thomas Kelder , Martijn Van Iersel , Christine Chichester , Egon Willighagen , Martina Summer-Kutmon , Alex Pico , and Kristina Hanspers


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Homo sapiens



Pathway Ontology

benzo(a)pyrene metabolic pathway cellular detoxification pathway xenobiotics biodegradation pathway


Label Type Compact URI Comment
Benzo[a]pyrene-9-sulfate Metabolite pubchem.compound:149850
7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene Metabolite chemspider:24123
Benzo[a]pyrene-7,8-dione Metabolite pubchem.compound:105020
Benzo[a]pyrene Metabolite pubchem.compound:2336
Benzo[a]pyrene-7-sulfate Metabolite pubchem.compound:23703977
9,10-epoxy-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene Metabolite chemspider:46738
Benzo[a]pyrene-1,6-dione Metabolite pubchem.compound:18300
CYP3A4 GeneProduct ensembl:ENSG00000160868
AKR1C2 GeneProduct ensembl:ENSG00000151632
AKR1C3 GeneProduct ensembl:ENSG00000196139
CYP1A1 GeneProduct ensembl:ENSG00000140465
AKR1A1 GeneProduct ensembl:ENSG00000117448
EPHX1 GeneProduct ensembl:ENSG00000143819
AKR1C4 GeneProduct ensembl:ENSG00000198610
CYP1A1 GeneProduct ensembl:ENSG00000140465
AKR1C1 GeneProduct ensembl:ENSG00000187134
CYP1B1 GeneProduct ensembl:ENSG00000138061
CYP1B1 GeneProduct ensembl:ENSG00000138061


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