Brain derived neurotrophic factor (WP2148)
Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.
AuthorsDavid , Daniela Digles , Martina Summer-Kutmon , and Alex Pico
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Pathway Ontologybrain-derived neurotrophic factor signaling pathway
|Erk2 (MAPK 1)||GeneProduct||ncbigene:116590|
- Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, et al. Science. 2004 Oct 15;306(5695):487–91. PubMed Europe PMC Scholia
- Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, et al. Nat Neurosci. 2005 Aug;8(8):1069–77. PubMed Europe PMC Scholia
- Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains. Neeley EW, Berger R, Koenig JI, Leonard S. Neuroscience. 2011 Jul 28;187:24–35. PubMed Europe PMC Scholia
- Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing. Ding Q, Ying Z, Gómez-Pinilla F. Neuroscience. 2011 Sep 29;192:773–80. PubMed Europe PMC Scholia