Brain derived neurotrophic factor (WP2148)

Rattus norvegicus

Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.


David , Daniela Digles , Martina Summer-Kutmon , and Alex Pico


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Rattus norvegicus



Pathway Ontology

brain-derived neurotrophic factor signaling pathway


Label Type Compact URI Comment
mBDNF GeneProduct ncbigene:24225
proBDNF GeneProduct ncbigene:24225
TrkB GeneProduct ncbigene:25054
tPA GeneProduct ncbigene:25692
PAI-1 GeneProduct ncbigene:24617
Erk2 (MAPK 1) GeneProduct ncbigene:116590
p75 GeneProduct ncbigene:24596
plasminogen GeneProduct ncbigene:85253
MAP2K1 GeneProduct ncbigene:170851
Ras GeneProduct ncbigene:24525
Raf GeneProduct ncbigene:24703
proBDNF GeneProduct ncbigene:24225
BDNF GeneProduct ncbigene:24225


  1. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, et al. Science. 2004 Oct 15;306(5695):487–91. PubMed Europe PMC Scholia
  2. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, et al. Nat Neurosci. 2005 Aug;8(8):1069–77. PubMed Europe PMC Scholia
  3. Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains. Neeley EW, Berger R, Koenig JI, Leonard S. Neuroscience. 2011 Jul 28;187:24–35. PubMed Europe PMC Scholia
  4. Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing. Ding Q, Ying Z, Gómez-Pinilla F. Neuroscience. 2011 Sep 29;192:773–80. PubMed Europe PMC Scholia