Type II interferon signaling (IFNG) (WP1253)
Mus musculus
Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]
Authors
De-Cheng Chao , Alex Pico , Kristina Hanspers , Daniela Digles , and Martina Summer-KutmonActivity
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Cited In
- Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local anti-tumor immunity in the tumor stroma (2022).
- Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice (2017).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
type II interferon signaling pathwayCell Type Ontology
macrophageLabel | Type | Compact Identifier | Comment |
---|---|---|---|
Ifng | GeneProduct | ncbigene:15978 | |
Ifng | GeneProduct | ncbigene:15978 | |
Ifng | GeneProduct | ncbigene:15978 | |
Ifngr1 | GeneProduct | ncbigene:15979 | |
Ifngr2 | GeneProduct | ncbigene:15980 | |
Jak1 | GeneProduct | ncbigene:16451 | |
Jak2 | GeneProduct | ncbigene:16452 | |
Jak2 | GeneProduct | ncbigene:16452 | |
Ifngr2 | GeneProduct | ncbigene:15980 | |
Ifngr1 | GeneProduct | ncbigene:15979 | |
Jak1 | GeneProduct | ncbigene:16451 | |
Ifng | GeneProduct | ncbigene:15978 | |
Jak2 | GeneProduct | ncbigene:16452 | |
Ifngr2 | GeneProduct | ncbigene:15980 | |
Ifngr1 | GeneProduct | ncbigene:15979 | |
Jak1 | GeneProduct | ncbigene:16451 | |
Ifngr2 | GeneProduct | ncbigene:15980 | |
Ifng | GeneProduct | ncbigene:15978 | |
Jak1 | GeneProduct | ncbigene:16451 | |
Jak2 | GeneProduct | ncbigene:16452 | |
Ifngr1 | GeneProduct | ncbigene:15979 | |
Socs3 | GeneProduct | ncbigene:12702 | |
Socs1 | GeneProduct | ncbigene:12703 | |
Ptpn11 | GeneProduct | ncbigene:19247 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat2 | GeneProduct | ncbigene:20847 | |
Stat2 | GeneProduct | ncbigene:20847 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat2 | GeneProduct | ncbigene:20847 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Irf9 | GeneProduct | ncbigene:16391 | |
Irf9 | GeneProduct | ncbigene:16391 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Irf9 | GeneProduct | ncbigene:16391 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Prkcd | GeneProduct | ncbigene:18753 | |
Reg1 | GeneProduct | ncbigene:19692 | |
Irf4 | GeneProduct | ncbigene:16364 | |
Sfpi1 | GeneProduct | ncbigene:20375 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat2 | GeneProduct | ncbigene:20847 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Irf9 | GeneProduct | ncbigene:16391 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Irf9 | GeneProduct | ncbigene:16391 | |
IFNA | GeneProduct | ncbigene:111654 | |
Ifnb1 | GeneProduct | ncbigene:15977 | |
Nos2 | GeneProduct | ncbigene:18126 | |
GBP1 | GeneProduct | ncbigene:14468 | |
HIST2H4 | GeneProduct | ncbigene:97122 | |
Psmb9 | GeneProduct | ncbigene:16912 | |
Tap1 | GeneProduct | ncbigene:21354 | |
Cxcl10 | GeneProduct | ncbigene:15945 | |
Ciita | GeneProduct | ncbigene:12265 | |
Cybb | GeneProduct | ncbigene:13058 | |
Il1b | GeneProduct | ncbigene:16176 | |
Ifit2 | GeneProduct | ncbigene:15958 | |
Eif2ak2 | GeneProduct | ncbigene:19106 | |
Irf1 | GeneProduct | ncbigene:16362 | |
Icam1 | GeneProduct | ncbigene:15894 | |
Cxcl9 | GeneProduct | ncbigene:17329 | |
Isg15 | GeneProduct | ncbigene:100038882 | |
Irf8 | GeneProduct | ncbigene:15900 | |
Irf8 | GeneProduct | ncbigene:15900 | |
Irf2 | GeneProduct | ncbigene:16363 |
References
- A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia