Type II interferon signaling (IFNG) (WP1253)

Mus musculus

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Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Authors

De-Cheng Chao , Alex Pico , Kristina Hanspers , Daniela Digles , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

type II interferon signaling pathway

Cell Type Ontology

macrophage

Participants

Label Type Compact Identifier Comment
Ifng GeneProduct ncbigene:15978
Ifng GeneProduct ncbigene:15978
Ifng GeneProduct ncbigene:15978
Ifngr1 GeneProduct ncbigene:15979
Ifngr2 GeneProduct ncbigene:15980
Jak1 GeneProduct ncbigene:16451
Jak2 GeneProduct ncbigene:16452
Jak2 GeneProduct ncbigene:16452
Ifngr2 GeneProduct ncbigene:15980
Ifngr1 GeneProduct ncbigene:15979
Jak1 GeneProduct ncbigene:16451
Ifng GeneProduct ncbigene:15978
Jak2 GeneProduct ncbigene:16452
Ifngr2 GeneProduct ncbigene:15980
Ifngr1 GeneProduct ncbigene:15979
Jak1 GeneProduct ncbigene:16451
Ifngr2 GeneProduct ncbigene:15980
Ifng GeneProduct ncbigene:15978
Jak1 GeneProduct ncbigene:16451
Jak2 GeneProduct ncbigene:16452
Ifngr1 GeneProduct ncbigene:15979
Socs3 GeneProduct ncbigene:12702
Socs1 GeneProduct ncbigene:12703
Ptpn11 GeneProduct ncbigene:19247
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Stat2 GeneProduct ncbigene:20847
Stat2 GeneProduct ncbigene:20847
Stat1 GeneProduct ncbigene:20846
Stat2 GeneProduct ncbigene:20847
Stat1 GeneProduct ncbigene:20846
Irf9 GeneProduct ncbigene:16391
Irf9 GeneProduct ncbigene:16391
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Irf9 GeneProduct ncbigene:16391
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Prkcd GeneProduct ncbigene:18753
Reg1 GeneProduct ncbigene:19692
Irf4 GeneProduct ncbigene:16364
Sfpi1 GeneProduct ncbigene:20375
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Stat2 GeneProduct ncbigene:20847
Stat1 GeneProduct ncbigene:20846
Irf9 GeneProduct ncbigene:16391
Stat1 GeneProduct ncbigene:20846
Stat1 GeneProduct ncbigene:20846
Irf9 GeneProduct ncbigene:16391
IFNA GeneProduct ncbigene:111654
Ifnb1 GeneProduct ncbigene:15977
Nos2 GeneProduct ncbigene:18126
GBP1 GeneProduct ncbigene:14468
HIST2H4 GeneProduct ncbigene:97122
Psmb9 GeneProduct ncbigene:16912
Tap1 GeneProduct ncbigene:21354
Cxcl10 GeneProduct ncbigene:15945
Ciita GeneProduct ncbigene:12265
Cybb GeneProduct ncbigene:13058
Il1b GeneProduct ncbigene:16176
Ifit2 GeneProduct ncbigene:15958
Eif2ak2 GeneProduct ncbigene:19106
Irf1 GeneProduct ncbigene:16362
Icam1 GeneProduct ncbigene:15894
Cxcl9 GeneProduct ncbigene:17329
Isg15 GeneProduct ncbigene:100038882
Irf8 GeneProduct ncbigene:15900
Irf8 GeneProduct ncbigene:15900
Irf2 GeneProduct ncbigene:16363

References

  1. A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia