Biosynthesis and regulation of nematode bile acids (WP2293)

Caenorhabditis elegans


Anwesha Bohler , Christine Chichester , Egon Willighagen , and Alex Pico


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Caenorhabditis elegans



Pathway Ontology

bile acid biosynthetic pathway


Label Type Compact URI Comment
Cholesterol Metabolite hmdb:HMDB0000067
7-Dehydrocholesterol Metabolite hmdb:HMDB0000032
Lathosterol Metabolite hmdb:HMDB0001170
Lathosterone Metabolite chebi:71550
Cholestenone Metabolite hmdb:HMDB0000921
DAF-36 GeneProduct ensembl:WBGene00007536
EMB-8 GeneProduct ensembl:WBGene00001262
DAF-9 GeneProduct ensembl:T13C5.1
DHS-16 GeneProduct wormbase:WBGene00000979
EMB-8 GeneProduct ensembl:WBGene00001262
DAF-9 GeneProduct ensembl:WBGene00000905
HSD-1 Protein wormbase:Y6B3B.11


  1. Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Rottiers V, Motola DL, Gerisch B, Cummins CL, Nishiwaki K, Mangelsdorf DJ, et al. Dev Cell. 2006 Apr;10(4):473–82. PubMed Europe PMC Scholia
  2. The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, et al. Aging Cell. 2011 Oct;10(5):879–84. PubMed Europe PMC Scholia