mRNA processing (WP310)

Mus musculus

Adapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated. 5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds. 3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion. Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule. Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification

Authors

Nathan Salomonis , Alex Pico , Thomas Kelder , Kristina Hanspers , Daniela Digles , Cizar , and Friederike Ehrhart

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

spliceosome pathway

Participants

Label Type Compact URI Comment
Polr2a GeneProduct ncbigene:20020
Rbm19 GeneProduct ncbigene:74111 Derived from InterPro
Zfml GeneProduct ncbigene:18139 Derived from InterPro
3100004P22Rik GeneProduct ncbigene:68035 Derived from InterPro
D1Pas1 GeneProduct ncbigene:110957
U2af1-rs2 GeneProduct ncbigene:22184 Derived from InterPro
AI503051 GeneProduct mgi:MGI:2141434 Derived from InterPro
Rae1 GeneProduct ncbigene:66679
D330023I21Rik GeneProduct ncbigene:237073 Derived from InterPro
Rnu1b6 GeneProduct ncbigene:19847 Derived from InterPro
Ssa2 GeneProduct ncbigene:20822
Sf3b3 GeneProduct ncbigene:101943
2210008M09Rik GeneProduct ncbigene:207920 Derived from InterPro
Hnrpa1 GeneProduct ncbigene:15382
Cpeb4 GeneProduct ncbigene:67579 Derived from InterPro
0610009D07Rik GeneProduct ncbigene:66055 Derived from InterPro
Xrn2 GeneProduct ncbigene:24128
Htf9c GeneProduct ncbigene:15547 Derived from InterPro
Son GeneProduct ncbigene:20658
Zfp385 GeneProduct ncbigene:29813
Sfrs14 GeneProduct ncbigene:234373
Ddx4 GeneProduct ncbigene:13206
Zmat2 GeneProduct ncbigene:66492
Adar GeneProduct ncbigene:56417
Sfrs10 GeneProduct ncbigene:20462
1110017C15Rik GeneProduct ncbigene:66164
Rpp14 GeneProduct ncbigene:67053
Rnasel GeneProduct ncbigene:24014
Txnl4 GeneProduct ncbigene:27366
Exosc4 GeneProduct ncbigene:109075
2400002F11Rik GeneProduct ncbigene:66405
6330548G22Rik GeneProduct ncbigene:76167 Derived from InterPro
2610024A01Rik GeneProduct ncbigene:72160 Derived from InterPro
Tenr GeneProduct ncbigene:21744
Rnu1a2 GeneProduct ncbigene:111972
Cpeb1 GeneProduct ncbigene:12877 Derived from InterPro
Rngtt GeneProduct ncbigene:24018
Secisbp2 GeneProduct ncbigene:75420
Rnu2 GeneProduct ncbigene:19848 GenBank sequence: K00027
Rpl26 GeneProduct ncbigene:19941
MGI:1351465 GeneProduct ncbigene:27041 Derived from InterPro
Cpsf5 GeneProduct ncbigene:68219
AI256354 GeneProduct ncbigene:103653 Derived from InterPro
Rbm4 GeneProduct ncbigene:19653 Derived from InterPro
Afg3l2 GeneProduct ncbigene:69597 Derived from InterPro
Rnps1 GeneProduct ncbigene:19826 PMID: 14729963
1700095D18Rik GeneProduct mgi:MGI:1920805 Derived from InterPro
Hnrpr GeneProduct ncbigene:74326
Hnrpdl GeneProduct ncbigene:50926 Derived from InterPro
1190002L16Rik GeneProduct ncbigene:102462
Exosc9 GeneProduct ncbigene:50911
Park7 GeneProduct ncbigene:57320
Rbm17 GeneProduct ncbigene:76938
1700012H05Rik GeneProduct ncbigene:76572 Derived from InterPro
Nono GeneProduct ncbigene:53610
Rpl38 GeneProduct ncbigene:67671
AI255215 GeneProduct mgi:MGI:2138868 Derived from InterPro
1200009B18Rik GeneProduct ncbigene:67456 Derived from InterPro
Rpl7 GeneProduct ncbigene:19989
MGI:1336880 GeneProduct ncbigene:20624
4921506I22Rik GeneProduct ncbigene:66704 Derived from InterPro
4932422E22Rik GeneProduct ncbigene:319695 Derived from InterPro
Snrpd1 GeneProduct ncbigene:20641
Ddx19b GeneProduct ncbigene:234733
4930554P13Rik GeneProduct mgi:MGI:1922548 Derived from InterPro
Snrpa GeneProduct ncbigene:53607
Pabpc5 GeneProduct ncbigene:93728 Derived from InterPro
Eif3s4 GeneProduct ncbigene:53356 Derived from InterPro
Sfrs11 GeneProduct ncbigene:69207
AW553050 GeneProduct mgi:MGI:2142260 Derived from InterPro
Snrpb GeneProduct ncbigene:20638
Ewsr1 GeneProduct ncbigene:14030 Derived from InterPro
Smn1 GeneProduct ncbigene:20595
MGI:2387367 GeneProduct ncbigene:241490 Derived from InterPro
2810055E05Rik GeneProduct ncbigene:230780
BB131279 GeneProduct ncbigene:103061 Derived from InterPro
Exosc7 GeneProduct ncbigene:66446
Cstf3 GeneProduct ncbigene:228410
Rps28 GeneProduct ncbigene:54127
PRP17_MOUSE GeneProduct uniprot:Q9DC48
Oas1a GeneProduct ncbigene:246730
Sbno1 GeneProduct ncbigene:243272 Derived from InterPro
Rpl9 GeneProduct ncbigene:20005
Papolg GeneProduct ncbigene:216578
Sf4 GeneProduct ncbigene:70616 inferred from: SURP 2, G patch protein, UniProt:O60378
Prkr GeneProduct ncbigene:19106
B930007L02Rik GeneProduct ncbigene:321006 Derived from InterPro
MGI:1926224 GeneProduct ncbigene:268859 Derived from InterPro
Bclaf1 GeneProduct ncbigene:72567 Derived from InterPro
Ppie GeneProduct ncbigene:56031 Derived from InterPro
Rnaseh2a GeneProduct ncbigene:69724
Rnu1b2 GeneProduct ncbigene:19845
AI256346 GeneProduct ncbigene:105123 Derived from InterPro
Tiaf1 GeneProduct ncbigene:21842 Derived from InterPro
Rpl39 GeneProduct ncbigene:67248
Rad21 GeneProduct ncbigene:19357
Fxr2h GeneProduct ncbigene:23879
C85084 GeneProduct mgi:MGI:2140695 Derived from InterPro
Adarb2 GeneProduct ncbigene:94191
Sfpq GeneProduct ncbigene:71514
Fus GeneProduct ncbigene:233908
Sfrs8 GeneProduct ncbigene:231769
Pskh1 GeneProduct ncbigene:244631 PMID: 12466556
Ppp1r8 GeneProduct ncbigene:100336
Cd2bp2 GeneProduct ncbigene:70233
Lrrn6a GeneProduct ncbigene:235402 Derived from InterPro
0610009C03Rik GeneProduct ncbigene:66585
Rps23 GeneProduct ncbigene:66475
Papola GeneProduct ncbigene:18789
Sfrs9 GeneProduct ncbigene:108014 PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
Rbmy1a1 GeneProduct ncbigene:19657 Derived from InterPro
Hnrpa3 GeneProduct ncbigene:229279
Ddx3x GeneProduct ncbigene:13205
Bard1 GeneProduct ncbigene:12021
Prpf4 GeneProduct ncbigene:70052
Zbp1 GeneProduct ncbigene:58203
4932422M17Rik GeneProduct ncbigene:74366 Derived from InterPro
AW049977 GeneProduct mgi:MGI:2142752 Derived from InterPro
Dazl GeneProduct ncbigene:13164 Derived from InterPro
Pum1 GeneProduct ncbigene:80912
AI255230 GeneProduct ncbigene:98285 Derived from InterPro
1700003D06Rik GeneProduct mgi:MGI:1919466 Derived from InterPro
Prpf4b GeneProduct ncbigene:19134
Ciz1 GeneProduct ncbigene:68379
AI043106 GeneProduct ncbigene:103625 Derived from InterPro
Cugbp2 GeneProduct ncbigene:14007
Igf2bp1 GeneProduct ncbigene:140486 Derived from InterPro
Rnu12 GeneProduct ncbigene:104307 Derived from InterPro
Spen GeneProduct ncbigene:56381 Derived from InterPro
2610027L16Rik GeneProduct ncbigene:67842
Rpl22 GeneProduct ncbigene:19934
Mki67ip GeneProduct ncbigene:67949 Derived from InterPro
Rnu1b1 GeneProduct ncbigene:19844 Derived from InterPro
Rnpc1 GeneProduct ncbigene:56190 Derived from InterPro
Ddx48 GeneProduct ncbigene:192170
3110061K15Rik GeneProduct mgi:MGI:1920450 Derived from InterPro
1110033J19Rik GeneProduct ncbigene:66184
Matr3-ps1 GeneProduct ncbigene:17185 Derived from InterPro
Srp68 GeneProduct ncbigene:217337
Ptbp2 GeneProduct ncbigene:56195
Rbm11 GeneProduct ncbigene:224344 Derived from InterPro
2610031L17Rik GeneProduct ncbigene:68879
Ddx39 GeneProduct ncbigene:68278
2010003O18Rik GeneProduct ncbigene:384281
1110037F02Rik GeneProduct ncbigene:66185 Derived from InterPro
Pabpc1 GeneProduct ncbigene:18458 Derived from InterPro
Ddx41 GeneProduct ncbigene:72935
Elavl1 GeneProduct ncbigene:15568 Derived from InterPro
Snrp1c GeneProduct ncbigene:20630
Cstf1 GeneProduct ncbigene:67337
G3bp2-pending GeneProduct mgi:MGI:1346339 Derived from InterPro
Stau1 GeneProduct ncbigene:20853
Snrp70 GeneProduct ncbigene:20637
2610209F03Rik GeneProduct mgi:MGI:2149675 Derived from InterPro
Snrpb2 GeneProduct ncbigene:20639
4930534J06Rik GeneProduct mgi:MGI:2442955
Matr3 GeneProduct ncbigene:17184 Derived from InterPro
0610009J05Rik GeneProduct mgi:MGI:1921339 Derived from InterPro
Clk2 GeneProduct ncbigene:12748
Cugbp1 GeneProduct ncbigene:13046
Refbp2 GeneProduct ncbigene:56009 Derived from InterPro
D12Mgi43 GeneProduct ncbigene:104924 Derived from InterPro
2410003C20Rik GeneProduct ncbigene:66983
Dnajc8 GeneProduct ncbigene:68598
Nhp2l1 GeneProduct uniprot:Q9D0T1
U2af1-rs1 GeneProduct ncbigene:22183 Derived from InterPro
Ddx1 GeneProduct ncbigene:104721
B230333C21Rik GeneProduct ncbigene:338351 Derived from InterPro
Sart3 GeneProduct ncbigene:53890 Derived from InterPro
Col4a3 GeneProduct ncbigene:12828 Derived from InterPro
H2-Bf GeneProduct ncbigene:14962 Derived from InterPro
Sf3b2 GeneProduct ncbigene:319322
Rnu6 GeneProduct ncbigene:19862 GenBank sequence: M10329
G430095G15Rik GeneProduct mgi:MGI:2443869 Derived from InterPro
Mrps28 GeneProduct ncbigene:66230
Ncbp2 GeneProduct ncbigene:68092
Eif4a2 GeneProduct ncbigene:13682
Dhx9 GeneProduct ncbigene:13211
Ddx24 GeneProduct ncbigene:27225
4930565A21Rik GeneProduct ncbigene:319586 Derived from InterPro
Fnbp3 GeneProduct ncbigene:56194
Wdr55 GeneProduct ncbigene:67936 Derived from InterPro
Brunol4 GeneProduct ncbigene:108013
Ppargc1a GeneProduct ncbigene:19017 Derived from InterPro
Htatsf1 GeneProduct ncbigene:72459 Derived from InterPro
Sfrs12 GeneProduct ncbigene:218543 Derived from InterPro
D19Bwg1357e GeneProduct ncbigene:52874
4930517K11Rik GeneProduct ncbigene:68172
Snrpn GeneProduct ncbigene:20646
Cdc40 GeneProduct ncbigene:71713
Taf15 GeneProduct ncbigene:70439 Derived from InterPro
Sfrs1 GeneProduct ncbigene:110809 Antagonist splicing factor
2010319N22Rik GeneProduct mgi:MGI:1917273 Derived from InterPro
Cdk9 GeneProduct ncbigene:107951 Derived from InterPro
Hnrpa3 GeneProduct ncbigene:229279 Derived from InterPro
C430048L16Rik GeneProduct ncbigene:77604 Derived from InterPro
2700088M22Rik GeneProduct ncbigene:67197 Derived from InterPro
Bicc1 GeneProduct ncbigene:83675
2010300K22Rik GeneProduct mgi:MGI:1913726 Derived from InterPro
Rnu1a1 GeneProduct ncbigene:19842 GenBank sequence: J00645
Ppp1r14b GeneProduct ncbigene:18938 Derived from InterPro
Rps29 GeneProduct ncbigene:20090
Sfrs4 GeneProduct ncbigene:57317
Dhx8 GeneProduct ncbigene:217207
Rbm12 GeneProduct ncbigene:75710 Derived from InterPro
Rnu1b1 GeneProduct ncbigene:19844
2410112D09Rik GeneProduct mgi:MGI:1920919 Derived from InterPro
Dkc1 GeneProduct ncbigene:108025
D9Mgi24 GeneProduct ncbigene:102460 Derived from InterPro
9630048M01Rik GeneProduct ncbigene:320158
AI462438 GeneProduct ncbigene:98985
B230118G17Rik GeneProduct mgi:MGI:1915415 Derived from InterPro
Ilf3 GeneProduct ncbigene:16201
Hnrpk GeneProduct ncbigene:15387
Tial1 GeneProduct ncbigene:21843 Derived from InterPro
D230005D02Rik GeneProduct ncbigene:239188 Derived from InterPro
Ppil4 GeneProduct ncbigene:67418 Derived from InterPro
9530027K23Rik GeneProduct ncbigene:77411 Derived from InterPro
Zfp622 GeneProduct ncbigene:52521
Prpf8 GeneProduct ncbigene:192159
Ddx25 GeneProduct ncbigene:30959
Oasl2 GeneProduct ncbigene:23962
2810442I21Rik GeneProduct ncbigene:72735 Derived from InterPro
3830425H19Rik GeneProduct mgi:MGI:1923985 Derived from InterPro
1190005F20Rik GeneProduct ncbigene:98685
8030431D03Rik GeneProduct mgi:MGI:1924422 Derived from InterPro
Phf5a GeneProduct ncbigene:68479
Csad GeneProduct ncbigene:246277 Derived from InterPro
4930506D01Rik GeneProduct mgi:MGI:1922339 Derived from InterPro
Pcbp1 GeneProduct ncbigene:23983
Exosc8 GeneProduct ncbigene:69639
5730557B15Rik GeneProduct ncbigene:67434 Derived from InterPro
Srpk2 GeneProduct ncbigene:20817 PMID: 12773558
Rpl8 GeneProduct ncbigene:26961
2610020N02Rik GeneProduct ncbigene:353258 Derived from InterPro
Rbm10 GeneProduct ncbigene:236732 Derived from InterPro
Rps27 GeneProduct ncbigene:57294
Nufip1 GeneProduct ncbigene:27275
Imp4 GeneProduct ncbigene:27993
Lsm4 GeneProduct ncbigene:50783
Rbmxrt GeneProduct ncbigene:19656
Aco1 GeneProduct ncbigene:11428
Wbscr1 GeneProduct ncbigene:22384 Derived from InterPro
Hnrpa2b1 GeneProduct ncbigene:53379
Rod1 GeneProduct ncbigene:230257 Derived from InterPro
C330027G06Rik GeneProduct ncbigene:68280 Derived from InterPro
Cstf2t GeneProduct ncbigene:83410
Eif4e3 GeneProduct ncbigene:66892
1300006N24Rik GeneProduct ncbigene:71766 Derived from InterPro
Ppargc1b GeneProduct ncbigene:170826 Derived from InterPro
Slc6a8 GeneProduct ncbigene:102857 Derived from InterPro
AI642080 GeneProduct ncbigene:103805 Derived from InterPro
Tarbp2 GeneProduct ncbigene:21357
BC013481 GeneProduct ncbigene:245945 Derived from InterPro
D11Ertd730e GeneProduct ncbigene:193116
Dhx16 GeneProduct ncbigene:69192
Rpl12 GeneProduct ncbigene:269261
Rbm21 GeneProduct ncbigene:70044 Derived from InterPro
Cirbp GeneProduct ncbigene:12696 Derived from InterPro
Rad52b GeneProduct ncbigene:66599 Derived from InterPro
C230097K14Rik GeneProduct mgi:MGI:2441901 Derived from InterPro
Pabpc4 GeneProduct ncbigene:230721 Derived from InterPro
4922503N01Rik GeneProduct ncbigene:230603 Derived from InterPro
Elavl4 GeneProduct ncbigene:15572 Derived from InterPro
Brca1 GeneProduct ncbigene:12189
Ttc14 GeneProduct ncbigene:67120
Rpl11 GeneProduct ncbigene:67025
AI255840 GeneProduct mgi:MGI:2146810 Derived from InterPro
D3Jfr1 GeneProduct ncbigene:229663
AU045931 GeneProduct mgi:MGI:2141597 Derived from InterPro
Trim21 GeneProduct ncbigene:20821
Raly GeneProduct ncbigene:19383 Derived from InterPro
Eif4g2 GeneProduct ncbigene:13690 Derived from InterPro
5330419I02Rik GeneProduct mgi:MGI:2442152 Derived from InterPro
MGI:2661424 GeneProduct ncbigene:272009 PMID: 11684676
D15Ertd119e GeneProduct mgi:MGI:1261777 Derived from InterPro
Synj2 GeneProduct ncbigene:20975 Derived from InterPro
Hnrpl GeneProduct ncbigene:15388
Msi2h GeneProduct ncbigene:76626 Derived from InterPro
AL022933 GeneProduct mgi:MGI:2141534 Derived from InterPro
Zfp346 GeneProduct ncbigene:26919
Nol8 GeneProduct ncbigene:70930 Derived from InterPro
Eif3s9 GeneProduct ncbigene:27979 Derived from InterPro
Polr2g GeneProduct ncbigene:67710
Rbm13 GeneProduct ncbigene:67920 Derived from InterPro
Ssb GeneProduct ncbigene:20823 Derived from InterPro
Hnrpa0 GeneProduct ncbigene:77134 Derived from InterPro
AI255219 GeneProduct mgi:MGI:2143545 Derived from InterPro
Hrmt1l2 GeneProduct ncbigene:15469
Lgtn GeneProduct ncbigene:16865
Traf6 GeneProduct ncbigene:22034 Derived from InterPro
D8Ertd233e GeneProduct ncbigene:52202 Derived from InterPro
Eif4e2 GeneProduct ncbigene:26987
Rpl32 GeneProduct ncbigene:19951
D5Ertd700e GeneProduct ncbigene:52387 Derived from InterPro
Cova1 GeneProduct ncbigene:209224 Derived from InterPro
Rps20 GeneProduct ncbigene:67427
Sf3a1 GeneProduct ncbigene:67465
3200001K10Rik GeneProduct ncbigene:381626 Derived from InterPro
Rbms3 GeneProduct ncbigene:207181 Derived from InterPro
AI255207 GeneProduct ncbigene:102459 Derived from InterPro
2810036M01Rik GeneProduct mgi:MGI:1919914 Derived from InterPro
Eif4e GeneProduct ncbigene:13684
Rnpep GeneProduct ncbigene:215615 Derived from InterPro
2610015J01Rik GeneProduct mgi:MGI:1917471 Derived from InterPro
AI255183 GeneProduct mgi:MGI:1353607 Derived from InterPro
Bat1a GeneProduct ncbigene:53817
AA589495 GeneProduct mgi:MGI:2143495 Derived from InterPro
Igf2bp3 GeneProduct ncbigene:140488 Derived from InterPro
Rnu11 GeneProduct ncbigene:353373 Derived from InterPro
Srrm1 GeneProduct ncbigene:51796
Ddx20 GeneProduct ncbigene:53975
Pcbp2 GeneProduct ncbigene:18521
AI447568 GeneProduct mgi:MGI:2139707 Derived from InterPro
Mbnl1 GeneProduct ncbigene:56758
AI194270 GeneProduct ncbigene:98871 Derived from InterPro
2810028N01Rik GeneProduct ncbigene:72662
Rnu108 GeneProduct ncbigene:104433 Derived from InterPro
Lsm2 GeneProduct ncbigene:27756
Tnrc4 GeneProduct ncbigene:78784 Derived from InterPro
Acin1 GeneProduct ncbigene:56215 Derived from InterPro
Nxf1 GeneProduct ncbigene:53319
2600016C11Rik GeneProduct mgi:MGI:1919317 Derived from InterPro
AI504630 GeneProduct mgi:MGI:2147572 Derived from InterPro
Oas3 GeneProduct ncbigene:246727
Grsf1 GeneProduct ncbigene:231413 Derived from InterPro
Lsm7 GeneProduct ncbigene:66094
Rps14 GeneProduct ncbigene:20044
Rbm28 GeneProduct ncbigene:68272 Derived from InterPro
C80672 GeneProduct mgi:MGI:2143933 Derived from InterPro
AI255750 GeneProduct mgi:MGI:2146392 Derived from InterPro
C79783 GeneProduct mgi:MGI:2142336 Derived from InterPro
U2af1 GeneProduct ncbigene:108121
Clk3 GeneProduct ncbigene:102414
5031411E02Rik GeneProduct mgi:MGI:2445088 Derived from InterPro
Rbpms GeneProduct ncbigene:19663 Derived from InterPro
Prpf3 GeneProduct ncbigene:70767
Tardbp GeneProduct ncbigene:230908 Derived from InterPro
Rps24 GeneProduct ncbigene:20088
U2af2 GeneProduct ncbigene:22185
Clk4 GeneProduct ncbigene:12750
Dhx38 GeneProduct ncbigene:64340
1810036A22Rik GeneProduct mgi:MGI:1916407 Derived from InterPro
AI844780 GeneProduct mgi:MGI:2141491 Derived from InterPro
Elavl3 GeneProduct ncbigene:15571 Derived from InterPro
AU023006 GeneProduct ncbigene:102683 Derived from InterPro
Sfrs3 GeneProduct ncbigene:20383
Rbm15b GeneProduct ncbigene:109095 Derived from InterPro
Akap1 GeneProduct ncbigene:11640
5730453I16Rik GeneProduct ncbigene:269061 Derived from InterPro
Sfrs11 GeneProduct ncbigene:69207 Derived from InterPro
Nhp2l1 GeneProduct ncbigene:20826
Rbm6 GeneProduct ncbigene:19654 Derived from InterPro
Tert GeneProduct ncbigene:21752
Sf3a3 GeneProduct ncbigene:75062
4930562C03Rik GeneProduct ncbigene:67667 Derived from InterPro
2610317D23Rik GeneProduct ncbigene:54614
Hnrpf GeneProduct ncbigene:98758 Derived from InterPro
Dnd1 GeneProduct ncbigene:213236 Derived from InterPro
Rbm8a GeneProduct ncbigene:60365 Derived from InterPro
Hnrpu GeneProduct ncbigene:51810
Ggcx GeneProduct ncbigene:56316 Derived from InterPro
Auh GeneProduct ncbigene:11992
Hnrph2 GeneProduct ncbigene:56258
Rbms2 GeneProduct ncbigene:56516 Derived from InterPro
Pabpc2 GeneProduct ncbigene:18459 Derived from InterPro
Sf3a2 GeneProduct ncbigene:20222
Rnu1a1 GeneProduct ncbigene:19842 Derived from InterPro
Spop GeneProduct ncbigene:20747
Nxf7 GeneProduct ncbigene:170722
Uhmk1 GeneProduct ncbigene:16589 Derived from InterPro
Cpsf3 GeneProduct ncbigene:54451
Nsap1l-pending GeneProduct mgi:MGI:1930916 Derived from InterPro
Slc25a4 GeneProduct ncbigene:11739 Derived from InterPro
Ptbp1 GeneProduct ncbigene:19205
Srp9 GeneProduct ncbigene:27058
Wbp4 GeneProduct ncbigene:22380
Fxr1h GeneProduct ncbigene:14359
Snrpd2 GeneProduct ncbigene:107686
Oas1g GeneProduct ncbigene:23960
0710005M24Rik GeneProduct ncbigene:76897 Derived from InterPro
Tnrc6c GeneProduct ncbigene:217351 Derived from InterPro
Rbm7 GeneProduct ncbigene:67010 Derived from InterPro
Rbmx GeneProduct ncbigene:19655 Derived from InterPro
Rnpc2 GeneProduct ncbigene:170791
Rbm22 GeneProduct ncbigene:66810 Derived from InterPro
Mrpl23 GeneProduct ncbigene:19935
Rbm31y GeneProduct ncbigene:74484 Derived from InterPro
Sf3b1 GeneProduct ncbigene:81898
1700025B16Rik GeneProduct ncbigene:69408 Derived from InterPro
Afg3l1 GeneProduct ncbigene:114896 Derived from InterPro
Cnot4 GeneProduct ncbigene:53621 Derived from InterPro
2410104I19Rik GeneProduct ncbigene:67959 Derived from InterPro
0610033I05Rik GeneProduct ncbigene:71684 Derived from InterPro
Pcolce GeneProduct ncbigene:18542 Derived from InterPro
A130095G20Rik GeneProduct mgi:MGI:2144767 Derived from InterPro
Cpsf2 GeneProduct ncbigene:51786
Elavl2 GeneProduct ncbigene:15569 Derived from InterPro
Rps4x GeneProduct ncbigene:20102
Sf3b4 GeneProduct ncbigene:107701
Safb2 GeneProduct ncbigene:224902 Derived from InterPro
Rbed1 GeneProduct ncbigene:232089 Derived from InterPro
Eif4g3 GeneProduct ncbigene:230861
Rps9 GeneProduct ncbigene:76846
Prpf18 GeneProduct ncbigene:67229
Cpsf1 GeneProduct ncbigene:94230
Scye1 GeneProduct ncbigene:13722
Sfrs5 GeneProduct ncbigene:20384
Rnaset2 GeneProduct ncbigene:68195
Ddx19a GeneProduct ncbigene:13680
Adam5 GeneProduct ncbigene:11499 Derived from InterPro
Mrpl11 GeneProduct ncbigene:66419
Srpk1 GeneProduct ncbigene:20815 PMID: 12773558
AI467299 GeneProduct ncbigene:106604 Derived from InterPro
Snrpf GeneProduct ncbigene:69878
1600023H17Rik GeneProduct mgi:MGI:1922893 Derived from InterPro
Pspc1 GeneProduct ncbigene:66645 Derived from InterPro
5730555F13Rik GeneProduct ncbigene:66660 Derived from InterPro
Srp19 GeneProduct ncbigene:66384
Rpl19 GeneProduct ncbigene:19921
Rps13 GeneProduct ncbigene:68052
Fmr1 GeneProduct ncbigene:14265
Pcbp3 GeneProduct ncbigene:59093
LSMD1_MOUSE GeneProduct uniprot:Q9D2U5
AI314192 GeneProduct mgi:MGI:2147861 Derived from InterPro
Poldip3 GeneProduct ncbigene:73826 Derived from InterPro
Mettl3 GeneProduct ncbigene:56335
2610023M21Rik GeneProduct mgi:MGI:1924186 Derived from InterPro
2600011C06Rik GeneProduct ncbigene:67039 Derived from InterPro
Exosc5 GeneProduct ncbigene:27998
4930422M05Rik GeneProduct mgi:MGI:2442597 Derived from InterPro
Lsm11 GeneProduct ncbigene:72290
Ppm1g GeneProduct ncbigene:14208 PMID: 12773558
3000004N20Rik GeneProduct ncbigene:72397 Derived from InterPro
2700077B20Rik GeneProduct mgi:MGI:1923845 Derived from InterPro
AI462171 GeneProduct ncbigene:103232 Derived from InterPro
1700009P03Rik GeneProduct ncbigene:74213 Derived from InterPro
Rbm16 GeneProduct ncbigene:106583 Derived from InterPro
Cyp4f18 GeneProduct ncbigene:72054 Derived from InterPro
Oas2 GeneProduct ncbigene:246728
Rnmtl1 GeneProduct ncbigene:67390
Tdrd7 GeneProduct ncbigene:100121 Derived from InterPro
V1rc17 GeneProduct ncbigene:171190 Derived from InterPro
D830027H13Rik GeneProduct mgi:MGI:2445140 Derived from InterPro
Hnrph1 GeneProduct ncbigene:59013
Cstf2t GeneProduct ncbigene:83410 Derived from InterPro
Rnmt GeneProduct ncbigene:67897
1500011J06Rik GeneProduct ncbigene:208606
Ddx6 GeneProduct ncbigene:13209
Rbm3 GeneProduct ncbigene:19652 Derived from InterPro
Boll GeneProduct ncbigene:75388 Derived from InterPro
Srp54 GeneProduct ncbigene:24067 PMID: 14729963
Smc1l1 GeneProduct ncbigene:24061
Hrmt1l1 GeneProduct ncbigene:15468
Syncrip GeneProduct ncbigene:56403 Derived from InterPro
9130414A06Rik GeneProduct mgi:MGI:1918855 Derived from InterPro
D1Pas1-rs1 GeneProduct mgi:MGI:99524
2610102M01Rik GeneProduct mgi:MGI:1919730 Derived from InterPro
Rbm18 GeneProduct ncbigene:67889 Derived from InterPro
Pum2 GeneProduct ncbigene:80913
Dazap1 GeneProduct ncbigene:70248 Derived from InterPro
6720478K01Rik GeneProduct mgi:MGI:1925151 Derived from InterPro
Tia1 GeneProduct ncbigene:21841 Derived from InterPro
Qk GeneProduct ncbigene:19317
Dhx15 GeneProduct ncbigene:13204
Snrpg GeneProduct ncbigene:68011
Lsm8 GeneProduct ncbigene:76522
Lsm1 GeneProduct ncbigene:67207
Rbpms2 GeneProduct ncbigene:71973 Derived from InterPro
Rbm17 GeneProduct ncbigene:76938 Derived from InterPro
Rnu2 GeneProduct ncbigene:19848 Derived from InterPro
Rnpepl1 GeneProduct ncbigene:108657 Derived from InterPro
AI255847 GeneProduct mgi:MGI:2138184 Derived from InterPro
1810035L17Rik GeneProduct ncbigene:380773 Derived from InterPro
Abcb4 GeneProduct ncbigene:18670 Derived from InterPro
Tmed10 GeneProduct ncbigene:68581
Srp14 GeneProduct ncbigene:20813
Rpl37 GeneProduct ncbigene:67281
Ddx5 GeneProduct ncbigene:13207
Hnrpc GeneProduct ncbigene:15381
4930429A22Rik GeneProduct ncbigene:208718
Ddx21 GeneProduct ncbigene:56200
Fusip1 GeneProduct ncbigene:14105
1810036E18Rik GeneProduct mgi:MGI:1925734 Derived from InterPro
Fbl GeneProduct ncbigene:14113
Sfrs2 GeneProduct ncbigene:20382
Pabpn1 GeneProduct ncbigene:54196
9430070C08Rik GeneProduct mgi:MGI:1924605 Derived from InterPro
Oas1b GeneProduct ncbigene:23961
4932702K14Rik GeneProduct ncbigene:67543 Derived from InterPro
Hnrpab GeneProduct ncbigene:15384
Sfrs16 GeneProduct ncbigene:53609
Pcbp4 GeneProduct ncbigene:59092
AA522010 GeneProduct mgi:MGI:2141367 Derived from InterPro
2310046H11Rik GeneProduct mgi:MGI:1922955 Derived from InterPro
2610101N10Rik GeneProduct ncbigene:67958 Derived from InterPro
AI843301 GeneProduct mgi:MGI:2146493 Derived from InterPro
Ddx56 GeneProduct ncbigene:52513
Msi1h GeneProduct ncbigene:17690 Derived from InterPro
Sfrs10 GeneProduct ncbigene:20462 Derived from InterPro
Cpeb3 GeneProduct ncbigene:208922 Derived from InterPro
Hdp GeneProduct mgi:MGI:104612 Derived from InterPro
AW260507 GeneProduct mgi:MGI:2147361 Derived from InterPro
Eral1 GeneProduct ncbigene:57837 Derived from InterPro
Hnrpd GeneProduct ncbigene:11991
5730557H03Rik GeneProduct mgi:MGI:1917910 Derived from InterPro
Adat1 GeneProduct ncbigene:30947
2810411C16Rik GeneProduct mgi:MGI:1916505 Derived from InterPro
2410013L13Rik GeneProduct mgi:MGI:2149671 Derived from InterPro
Rbm14 GeneProduct ncbigene:56275 Derived from InterPro
Rnu1b2 GeneProduct ncbigene:19845 Derived from InterPro
Cstf2 GeneProduct ncbigene:108062
Sca1 GeneProduct ncbigene:20238
Snrpe GeneProduct ncbigene:20643
4632417O19Rik GeneProduct mgi:MGI:1925510 Derived from InterPro
Tsn GeneProduct ncbigene:22099
Thoc4 GeneProduct ncbigene:21681 Derived from InterPro
Brunol6 GeneProduct ncbigene:76183 Derived from InterPro
D12Mgi40 GeneProduct ncbigene:104925 Derived from InterPro
Snrpd3 GeneProduct ncbigene:67332
Hnrpm GeneProduct ncbigene:76936
Sfrs6 GeneProduct ncbigene:67996
1700047G05Rik GeneProduct mgi:MGI:1914568 Derived from InterPro
Rps7 GeneProduct ncbigene:20115
Matr3-ps2 GeneProduct ncbigene:17186 Derived from InterPro
Cpsf4 GeneProduct ncbigene:54188
1110034O07Rik GeneProduct ncbigene:68744 Derived from InterPro
AW107884 GeneProduct mgi:MGI:2140554 Derived from InterPro
2600016F06Rik GeneProduct mgi:MGI:1913821 Derived from InterPro
Sf3b5 GeneProduct ncbigene:66125
Ncbp1 GeneProduct ncbigene:110519
Nsep1 GeneProduct ncbigene:22608
Sfrs12 GeneProduct ncbigene:218543 PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
Ncl GeneProduct ncbigene:17975 Derived from InterPro
Rdbp GeneProduct ncbigene:27632 Derived from InterPro
Sfrs7 GeneProduct ncbigene:225027
Rbms1 GeneProduct ncbigene:56878 Derived from InterPro
Rps11 GeneProduct ncbigene:27207
Rps6 GeneProduct ncbigene:20104
Npm1 GeneProduct ncbigene:18148
Dicer1 GeneProduct ncbigene:192119
Rbmx2 GeneProduct ncbigene:209003 Derived from InterPro
Tlr5 GeneProduct ncbigene:53791 Derived from InterPro
Snrpa1 GeneProduct ncbigene:68981
2810441O16Rik GeneProduct ncbigene:67225 Derived from InterPro
Rbmxrt GeneProduct ncbigene:19656 Derived from InterPro
Supt5h GeneProduct ncbigene:20924
Rbm5 GeneProduct ncbigene:83486
Slbp GeneProduct ncbigene:20492
Wdr9 GeneProduct ncbigene:93871 Derived from InterPro
Ilkap GeneProduct ncbigene:67444 Derived from InterPro
2700028P07Rik GeneProduct mgi:MGI:1924055 Derived from InterPro
1500012C14Rik GeneProduct mgi:MGI:1914382 Derived from InterPro
Myef2 GeneProduct ncbigene:17876 Derived from InterPro
Clk1 GeneProduct ncbigene:12747
Hnrpll GeneProduct ncbigene:72692 Derived from InterPro
Papolb GeneProduct ncbigene:56522
AA407033 GeneProduct mgi:MGI:2141802 Derived from InterPro
AI255212 GeneProduct ncbigene:101508 Derived from InterPro
Rbm9 GeneProduct ncbigene:93686 Derived from InterPro

References