PDGFR-beta pathway (WP3972)
Simplified PDGFR-beta pathway, based on figure 7B from Zhang et al: https://www.ncbi.nlm.nih.gov/pubmed/27372738 Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGFR homo- or heterodimerizes. Source: [https://en.wikipedia.org/wiki/Platelet-derived_growth_factor_receptor Wikipedia]
AuthorsKristina Hanspers , Alex Pico , and Friederike Ehrhart
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- Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood (2022).
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Pathway Ontologysignaling pathway ovarian cancer pathway cancer pathway
Disease Ontologyovarian cancer
- Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, et al. Cell. 2016 Jul 28;166(3):755–65. PubMed Europe PMC Scholia