PDGFR-beta pathway (WP3972)

Homo sapiens

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Simplified PDGFR-beta pathway, based on figure 7B from Zhang et al: https://www.ncbi.nlm.nih.gov/pubmed/27372738 Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGFR homo- or heterodimerizes. Source: [https://en.wikipedia.org/wiki/Platelet-derived_growth_factor_receptor Wikipedia] Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Authors

Kristina Hanspers , Alex Pico , and Friederike Ehrhart

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

ovarian cancer pathway cancer pathway signaling pathway

Disease Ontology

ovarian cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
PIK3CA GeneProduct ensembl:ENSG00000121879
PDGFRB GeneProduct ensembl:ENSG00000113721
PLCG1 GeneProduct ensembl:ENSG00000124181
PRKCA GeneProduct ensembl:ENSG00000154229
ERK1 GeneProduct ensembl:ENSG00000102882
GRB1 GeneProduct ensembl:ENSG00000145675
JAK1 GeneProduct ensembl:ENSG00000162434
PRKCB GeneProduct ensembl:ENSG00000166501
STAT6 GeneProduct ensembl:ENSG00000166888
JAK2 GeneProduct ensembl:ENSG00000096968
PKR GeneProduct ensembl:ENSG00000055332
STAT3 GeneProduct ensembl:ENSG00000168610
STAT1 GeneProduct ensembl:ENSG00000115415
STAT5A GeneProduct ensembl:ENSG00000126561
GRB2 GeneProduct ensembl:ENSG00000177885
HRAS GeneProduct ensembl:ENSG00000174775
SOS1 GeneProduct ensembl:ENSG00000115904
SHC1 GeneProduct ensembl:ENSG00000160691
RASA1 GeneProduct ensembl:ENSG00000145715
MEKK GeneProduct ensembl:ENSG00000095015
MEK1 GeneProduct ensembl:ENSG00000169032
STAT5B GeneProduct ensembl:ENSG00000173757
JNK1 GeneProduct ensembl:ENSG00000107643
JNKK1 GeneProduct ensembl:ENSG00000065559
RAF1 GeneProduct ensembl:ENSG00000132155
ELK1 GeneProduct ensembl:ENSG00000126767
SRF GeneProduct ensembl:ENSG00000112658
FOS GeneProduct ensembl:ENSG00000170345
JUN GeneProduct ensembl:ENSG00000177606

References

  1. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia
  2. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, et al. Cell. 2016 Jul 28;166(3):755–65. PubMed Europe PMC Scholia