Hexoses metabolism in proximal tubules (WP3916)

Rattus norvegicus

This pathways features carbohydrates metabolism in proximal tubules, and is ment to be used to visualize RNA chip expression data.


Agustin Gonzalez-Vicente , Alex Pico , Kristina Hanspers , Denise Slenter , Elisson nl , and Egon Willighagen


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Rattus norvegicus


Renal Genomics Pathways


Pathway Ontology

classic metabolic pathway carbohydrate metabolic pathway glycolysis/gluconeogenesis pathway

Disease Ontology

disease of metabolism acquired metabolic disease inherited metabolic disorder

Cell Type Ontology

epithelial cell of proximal tubule


Label Type Compact URI Comment
1,3BP-Glycerate Metabolite hmdb:HMDB0001270
Pyruvate Metabolite hmdb:HMDB0000243
Glucose Metabolite hmdb:HMDB0000122
Fructose 6P Metabolite hmdb:HMDB0000124
Pyruvate Metabolite hmdb:HMDB0000243
P-enolpyruvate Metabolite hmdb:HMDB0000263
Lactate Metabolite cas:79-33-4
3P-Glycerate Metabolite hmdb:HMDB0000807
Acetyl-CoA Metabolite cas:72-89-9
2P-Glycerate Metabolite hmdb:HMDB0000362
Dihydroxyacetone-P Metabolite hmdb:HMDB0001473
Fructose-1,6BP Metabolite hmdb:HMDB0001058
Glucose-6P Metabolite hmdb:HMDB0001401
Glucose Metabolite hmdb:HMDB0000122
Glyceraldehyde 3P Metabolite hmdb:HMDB0001112
Oxalacetate Metabolite hmdb:HMDB0000223
Malate Metabolite cas:6915-15-7
Malate Metabolite cas:6915-15-7
Oxalacetate Metabolite hmdb:HMDB0000223
Aspartate Metabolite cas:6915-15-7
Citrate Metabolite cas:6915-15-7
Aspartate Metabolite cas:6915-15-7
Citrate Metabolite cas:6915-15-7
Acetyl-CoA Metabolite cas:72-89-9
Fructose Metabolite hmdb:HMDB0000660
Sorbitol Metabolite hmdb:HMDB0000247
Fructose-1-P Metabolite hmdb:HMDB0001076
Glyderaldehyde Metabolite hmdb:HMDB0001051
Fructose Metabolite hmdb:HMDB0000660
Dlat GeneProduct ncbigene:81654
Slc2a2 GeneProduct ncbigene:25351
Tpi1 GeneProduct ncbigene:24849
Slc5a1 GeneProduct ncbigene:25552
Slc2a5 GeneProduct ncbigene:65197
Pgk1 GeneProduct ncbigene:24644
Gpi GeneProduct ncbigene:292804
Dld GeneProduct ncbigene:298942
Pdha2 GeneProduct ncbigene:117098
Pgam1 GeneProduct ncbigene:24642
Pdp2 GeneProduct ncbigene:246311
Pdhb GeneProduct ncbigene:289950
Pdhx GeneProduct ncbigene:311254
Gapdh GeneProduct ncbigene:24383
Pklr GeneProduct ncbigene:24651 Make sure to differentiate between M1 and M2 isoform
Mpc1 GeneProduct ncbigene:171087
Pdha1 GeneProduct ncbigene:29554
Pkm GeneProduct ncbigene:25630 2 Isoforms: L Liver and R red cells
Aldoa GeneProduct ncbigene:24189
Pgk2 GeneProduct ncbigene:316265
Pdp1 GeneProduct ncbigene:54705
Slc5a2 GeneProduct ncbigene:64522
Hk1 GeneProduct ncbigene:25058
Aldoc GeneProduct ncbigene:24191
Aldob GeneProduct ncbigene:24190
mpc2 GeneProduct ncbigene:100359982
Pdk1 GeneProduct ncbigene:116551
Pdk3 GeneProduct ncbigene:296849
Pdk2 GeneProduct ncbigene:81530
Pdk4 GeneProduct ncbigene:89813
Pc GeneProduct ncbigene:25104
Acly GeneProduct ncbigene:24159
Pfkl GeneProduct ncbigene:25741
Pfkp GeneProduct ncbigene:60416
Pfkm GeneProduct ncbigene:65152
Tkfc GeneProduct ncbigene:361730
Sord GeneProduct ncbigene:24788
Khk GeneProduct ncbigene:25659
Aldob GeneProduct ncbigene:24190
Akr1b1 GeneProduct ncbigene:24192
G6pc GeneProduct ncbigene:25634
Hk1 GeneProduct ncbigene:25058
Pgam2 GeneProduct ncbigene:24959
Eno1 GeneProduct ncbigene:24333
Eno3 GeneProduct ncbigene:25438
Eno2 GeneProduct ncbigene:24334
Pck1 GeneProduct ncbigene:362282
Got1 GeneProduct ncbigene:24401
Got2 GeneProduct ncbigene:25721
Mdh2 GeneProduct ncbigene:81829
Mdh1 GeneProduct ncbigene:24551
Cs GeneProduct ncbigene:170587
Ldhb GeneProduct ncbigene:24534 2 Isoforms: L Liver and R red cells
Ldha GeneProduct ncbigene:24533 Make sure to differentiate between M1 and M2 isoform
Slc5a10 GeneProduct ncbigene:303205
Slc2a2 GeneProduct ncbigene:25351
Slc5a9 GeneProduct ncbigene:366441
Slc2a5 GeneProduct ncbigene:65197
Fbp1 Protein ncbigene:24362


  1. SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Tazawa S, Yamato T, Fujikura H, Hiratochi M, Itoh F, Tomae M, et al. Life Sci. 2005 Jan 14;76(9):1039–50. PubMed Europe PMC Scholia
  2. Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter. Grempler R, Augustin R, Froehner S, Hildebrandt T, Simon E, Mark M, et al. FEBS Lett. 2012 Feb 3;586(3):248–53. PubMed Europe PMC Scholia
  3. SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. Fukuzawa T, Fukazawa M, Ueda O, Shimada H, Kito A, Kakefuda M, et al. PLoS One. 2013;8(2):e56681. PubMed Europe PMC Scholia
  4. Transcriptome signature for dietary fructose-specific changes in rat renal cortex: A quantitative approach to physiological relevance. Gonzalez-Vicente A, Garvin JL, Hopfer U. PLoS One. 2018 Aug 1;13(8):e0201293. PubMed Europe PMC Scholia
  5. Fructose reabsorption by rat proximal tubules: role of Na+-linked cotransporters and the effect of dietary fructose. Gonzalez-Vicente A, Cabral PD, Hong NJ, Asirwatham J, Saez F, Garvin JL. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F473–80. PubMed Europe PMC Scholia