Glutathione metabolism (WP100)
Homo sapiens
Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP100 CPTAC Assay Portal]
Authors
Thomas Kelder , Alex Pico , Andra Waagmeester , Egon Willighagen , Denise Slenter , and Kristina HanspersActivity
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Cited In
- Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease (2021).
- Copy Number Variants Captured by the Array Comparative Genomic Hybridization in a Cohort of Patients Affected with Hereditary Colorectal Cancer in Sri Lanka: The First CNV Analysis Study of the Hereditary Colorectal Cancer in the Sri Lankan Population (2021).
- Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
- Complementary Post Transcriptional Regulatory Information is Detected by PUNCH-P and Ribosome Profiling (2016).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
glutathione metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| g-L-Glutamyl-L-cysteine | Metabolite | kegg.compound:C00669 | |
| L-Cysteine | Metabolite | kegg.compound:C00097 | |
| Cysteinyl-glycine | Metabolite | kegg.compound:C01419 | |
| Glycine | Metabolite | hmdb:HMDB0000123 | |
| 5-Oxoproline | Metabolite | kegg.compound:C01879 | |
| Glycine | Metabolite | hmdb:HMDB0000123 | |
| L-Glutamate | Metabolite | kegg.compound:C00025 | |
| NADPH | Metabolite | hmdb:HMDB0000221 | |
| L-Glutamate | Metabolite | kegg.compound:C00025 | |
| (5-L-Glutamyl)-L-amino acid | Metabolite | kegg.compound:C03740 | |
| R-S-Mercapturonate | Metabolite | chebi:47911 | |
| L-Amino acid | Metabolite | kegg.compound:C00151 | |
| Bis-g-glutamylcystine | Metabolite | kegg.compound:C03646 | |
| R-S-Alanine | Metabolite | kegg.compound:C05726 | |
| Glutamylcysteinyl-glycylspermidine | Metabolite | pubchem.compound:440772 | |
| NADP+ | Metabolite | hmdb:HMDB0000217 | |
| Glutathione (reduced) | Metabolite | kegg.compound:C00051 | |
| R-S-Alanylglycine | Metabolite | kegg.compound:C05729 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| R-S-Glutathione | Metabolite | kegg.compound:C02320 | |
| Oxidized glutathione | Metabolite | kegg.compound:C00127 | |
| 2.3.1.80 | GeneProduct | eccode:2.3.1.80 | |
| GGTLA1 | GeneProduct | ncbigene:2687 | |
| 1.8.4.4 | GeneProduct | eccode:1.8.4.4 | |
| GGT1 | GeneProduct | ncbigene:2678 | (5-L-Glutamyl)-L-amino acid |
| GGTLA1 | GeneProduct | ncbigene:2687 | |
| 1.8.4.1 | GeneProduct | eccode:1.8.4.1 | |
| GPX1 | GeneProduct | ncbigene:2876 | |
| GSR | GeneProduct | ncbigene:2936 | |
| ANPEP | GeneProduct | ncbigene:290 | |
| 3.4.11.4 | GeneProduct | eccode:3.4.11.4 | |
| 2.3.2.4 | GeneProduct | eccode:2.3.2.4 | |
| 1.8.1.13 | GeneProduct | eccode:1.8.1.13 | |
| GSTA1 | GeneProduct | ncbigene:2938 | |
| GSTM2 | GeneProduct | ncbigene:2946 | |
| GPX2 | GeneProduct | ncbigene:2877 | |
| GSS | GeneProduct | ncbigene:2937 | |
| GCLC | GeneProduct | ncbigene:2729 | |
| GSTA5 | GeneProduct | ncbigene:221357 | |
| 1.8.4.3 | GeneProduct | eccode:1.8.4.3 | |
| IDH1 | GeneProduct | ncbigene:3417 | |
| 1.8.4.7 | GeneProduct | eccode:1.8.4.7 | |
| GGT1 | GeneProduct | ncbigene:2678 | |
| 1.8.5.1 | GeneProduct | eccode:1.8.5.1 | |
| GCLM | GeneProduct | ncbigene:2730 | |
| 1.8.4.2 | GeneProduct | eccode:1.8.4.2 | |
| GGT1 | GeneProduct | ncbigene:2678 | |
| GPX3 | GeneProduct | ncbigene:2878 | |
| 1.5.4.1 | GeneProduct | eccode:1.5.4.1 | |
| GSTT2 | GeneProduct | ncbigene:2953 | |
| 6.3.1.8 | GeneProduct | eccode:6.3.1.8 | |
| 1.1.1.43 | GeneProduct | eccode:1.1.1.43 | |
| 1.11.1.12 | GeneProduct | eccode:1.11.1.12 | |
| ANPEP | GeneProduct | ncbigene:290 | |
| OPLAH | GeneProduct | ncbigene:26873 | |
| 1.8.3.3 | GeneProduct | eccode:1.8.3.3 | |
| 2.3.2.4 | GeneProduct | eccode:2.3.2.4 | |
| GGTLA1 | GeneProduct | ncbigene:2687 | |
| GSTT1 | GeneProduct | ncbigene:2952 | |
| GPX4 | GeneProduct | ncbigene:2879 | |
| 2.8.1.3 | GeneProduct | eccode:2.8.1.3 | |
| G6PD | GeneProduct | ncbigene:2539 | |
| 3.5.1.78 | GeneProduct | eccode:3.5.1.78 | |
| GSTM1 | GeneProduct | ncbigene:2944 |
References
- Glutathione metabolism and its implications for health. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. J Nutr. 2004 Mar;134(3):489–92. PubMed Europe PMC Scholia