(A) FB-derived exosomes enriched with miR-21-3p or Spp1 and EGFR proteins are transferred to CMs, leading to CM hypertrophy. (B) EVs secreted from CMs or MSCs, as well as circulating EVs exert regulatory effects on CM apoptosis. (C) CM-derived exosomal HSP90 together with secreted IL-6 are able to activate STAT-3 signaling in cardiac FBs, leading to cardiac fibrosis; whereas CM-derived exosomes from exercised diabetic mice express high levels of miR-29b and miR-455, thus reducing cardiac fibrosis. (D) EVs secreted from CMs or MSCs are transferred to ECs, exerting pro- or anti-angiogenic activities. Description from Bei et al.

Authors

Kristina Hanspers , Anders Riutta , and Egon Willighagen

Cited In

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Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: cardiac muscle cell fibroblast of cardiac tissue cardiac endothelial cell

Participants

References

1. Bei Y, Das S, Rodosthenous RS, Holvoet P, Vanhaverbeke M, Monteiro MC, et al. Extracellular Vesicles in Cardiovascular Theranostics. Theranostics. 2017 Sep 26;7(17):4168–82. PubMed Europe PMC Scholia