Serotonin reuptake inhibitor response (WP5237)

Daphnia magna

Various biological pathways affected in response to exposure to serotonin reuptake inhibitors. After exposure the genes lace, cDASE, GlcT-1, ldh, Acon, Ddc, Fbp, and thiolase are upregulated, while Pfk, UGP, and ATPC are downregulated.


Egon Willighagen and Martina Summer-Kutmon


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.





Pathway Ontology

serotonin metabolic pathway


Label Type Compact URI Comment
cis-aconitate Metabolite chebi:32805
sphingosine Metabolite chebi:16393
D-glucose-1-p Metabolite chebi:16077
glycogen Metabolite chebi:28087
UDP-glucose Metabolite chebi:18066
Pyruvate Metabolite chebi:15361
Acetyl-CoA Metabolite chebi:15351
citrate Metabolite chebi:30769
3-oxo-hexanoyl-CoA Metabolite chebi:27648
Fatty acid Metabolite chebi:35366
tryptamine Metabolite chebi:16765
tryptamine Metabolite chebi:16765
tryptamine Metabolite chebi:16765
isocitrate Metabolite chebi:16087
oxalosuccinate Metabolite chebi:153066
2-oxoglutarate Metabolite chebi:16810
oxaloacetate Metabolite chebi:16452
ceramide Metabolite chebi:17761
Pfk GeneProduct ncbigene:91088313
GlyP GeneProduct ncbigene:91081301
UGP GeneProduct ncbigene:47086583
Fbp GeneProduct ncbigene:45550998
thiolase GeneProduct ncbigene:156369857
Ddc GeneProduct ncbigene:7768790
Ddc GeneProduct ncbigene:7768790
Acon GeneProduct ncbigene:17864292
Acon GeneProduct ncbigene:17864292


  1. Identification of metabolic pathways in Daphnia magna explaining hormetic effects of selective serotonin reuptake inhibitors and 4-nonylphenol using transcriptomic and phenotypic responses. Campos B, Garcia-Reyero N, Rivetti C, Escalon L, Habib T, Tauler R, et al. Environ Sci Technol. 2013 Aug 20;47(16):9434–43. PubMed Europe PMC Scholia