Serotonin reuptake inhibitor response (WP5237)

Daphnia magna

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Various biological pathways affected in response to exposure to serotonin reuptake inhibitors. After exposure the genes lace, cDASE, GlcT-1, ldh, Acon, Ddc, Fbp, and thiolase are upregulated, while Pfk, UGP, and ATPC are downregulated.

Authors

Egon Willighagen and Martina Summer-Kutmon

Activity

last edited

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Organisms

Communities

Daphnia

Annotations

Pathway Ontology

serotonin metabolic pathway

Participants

Label Type Compact URI Comment
cis-aconitate Metabolite chebi:32805
sphingosine Metabolite chebi:16393
D-glucose-1-p Metabolite chebi:16077
glycogen Metabolite chebi:28087
UDP-glucose Metabolite chebi:18066
Pyruvate Metabolite chebi:15361
Acetyl-CoA Metabolite chebi:15351
citrate Metabolite chebi:30769
3-oxo-hexanoyl-CoA Metabolite chebi:27648
Fatty acid Metabolite chebi:35366
tryptamine Metabolite chebi:16765
tryptamine Metabolite chebi:16765
tryptamine Metabolite chebi:16765
isocitrate Metabolite chebi:16087
oxalosuccinate Metabolite chebi:153066
2-oxoglutarate Metabolite chebi:16810
oxaloacetate Metabolite chebi:16452
ceramide Metabolite chebi:17761
Pfk GeneProduct ncbigene:91088313
GlyP GeneProduct ncbigene:91081301
UGP GeneProduct ncbigene:47086583
Fbp GeneProduct ncbigene:45550998
thiolase GeneProduct ncbigene:156369857
Ddc GeneProduct ncbigene:7768790
Ddc GeneProduct ncbigene:7768790
Acon GeneProduct ncbigene:17864292
Acon GeneProduct ncbigene:17864292

References

  1. Identification of metabolic pathways in Daphnia magna explaining hormetic effects of selective serotonin reuptake inhibitors and 4-nonylphenol using transcriptomic and phenotypic responses. Campos B, Garcia-Reyero N, Rivetti C, Escalon L, Habib T, Tauler R, et al. Environ Sci Technol. 2013 Aug 20;47(16):9434–43. PubMed Europe PMC Scholia