Eicosanoid metabolism via cytochrome P450 monooxygenases pathway (WP4720)

Homo sapiens

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This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display and extended with the bottom left side of Figure 1 from (Dennis and Norris (2015)). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX) WP4347, lipooxygenases(LOX) WP4348, or cytochrome P450 monooxygenases (CYP) WP4349. This pathway visualizes the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Denise Slenter , Eric Weitz , Egon Willighagen , Kristina Hanspers , and Daniela Digles

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS ONTOX

Annotations

Pathway Ontology

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism eicosanoid metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Arachidonic acid Metabolite lipidmaps:LMFA01030001
16-HETE Metabolite lipidmaps:LMFA03090010
17-HETE Metabolite lipidmaps:LMFA03060091
18-HETE Metabolite lipidmaps:LMFA03060092
19-HETE Metabolite lipidmaps:LMFA03060106
20-HETE Metabolite lipidmaps:LMFA03060009
5,6-EpETrE Metabolite lipidmaps:LMFA03080002
8,9-EpETrE Metabolite lipidmaps:LMFA03080003
11,12-EpETrE Metabolite lipidmaps:LMFA03090010
14,15-EpETrE Metabolite lipidmaps:LMFA03080005
5,6-DiHETrE Metabolite lipidmaps:LMFA03050004
8,9-DiHETrE Metabolite lipidmaps:LMFA03050006
11,12-DiHETrE Metabolite lipidmaps:LMFA03050008
14,15-DiHETrE Metabolite lipidmaps:LMFA03050010
EPHX2 GeneProduct ensembl:ENSG00000120915 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13850
CYP4A11 GeneProduct ensembl:ENSG00000187048 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
CYP4A22 GeneProduct ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753
CYP4A22 GeneProduct ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
CYP4F12 GeneProduct ensembl:ENSG00000186204 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
CYP4F2 GeneProduct ensembl:ENSG00000186115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
PPAR gamma Protein uniprot:P37231 AKA Peroxisome proliferator-activated receptor gamma
CYP2C8 Protein ensembl:ENSG00000138115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13095
CYP2C8 Protein ensembl:ENSG00000138115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13097
CYP2C8 Protein ensembl:ENSG00000138115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13098
CYP2C18 Protein ensembl:ENSG00000108242 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72082
PPARA Protein ensembl:ENSG00000186951 AKA Peroxisome proliferator-activated receptor alpha
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204

References

  1. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  2. Eicosanoid storm in infection and inflammation. Dennis EA, Norris PC. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia