Eicosanoid metabolism via cyclooxygenases (COX) (WP4719)

Homo sapiens

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This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display and extended with the top left side of Figure 1 from Dennis and Norris 2015. Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX) WP4347, lipooxygenases(LOX) WP4348, or cytochrome P450 monooxygenases (CYP) WP4349. This pathway visualizes the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes. Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Denise Slenter , Egon Willighagen , Eric Weitz , Conroy lipids , Kristina Hanspers , and Daniela Digles

Activity

last edited

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS ONTOX

Annotations

Pathway Ontology

inflammatory response pathway eicosanoid biosynthetic pathway arachidonic acid metabolic pathway cyclooxygenase mediated pathway of arachidonic acid metabolism eicosanoid biosynthetic pathway eicosanoid metabolic pathway eicosanoid signaling pathway eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma

Participants
Query Drugst.One

Label Type Compact URI Comment
Glycerophospholipids Metabolite chebi:37739
Arachidonic acid Metabolite lipidmaps:LMFA01030001
PGG2 Metabolite lipidmaps:LMFA03010009
PGH2 Metabolite lipidmaps:LMFA03010010
PGE2 Metabolite lipidmaps:LMFA03010003
PGF2a Metabolite lipidmaps:LMFA03010002
PGD2 Metabolite lipidmaps:LMFA03010004
PGJ2 Metabolite lipidmaps:LMFA03010019
delta-12-PGJ2 Metabolite lipidmaps:LMFA03010020
15-deoxy-delta-12-PGD2 Metabolite lipidmaps:LMFA03010021
11-HETE Metabolite lipidmaps:LMFA03060085
PGI2 Metabolite lipidmaps:LMFA03010087
6-keto-PGF1alpha Metabolite lipidmaps:LMFA03010001
6-keto-PGE1 Metabolite lipidmaps:LMFA03010012
PGA2 Metabolite lipidmaps:LMFA03010035
PGB2 Metabolite lipidmaps:LMFA03010018
15-deoxy-PGA2 Metabolite lipidmaps:LMFA03010172
Dinor-PGE2 Metabolite lipidmaps:LMFA03010210
Tetranor-PGE2 Metabolite lipidmaps:LMFA03010211
Dinor-PGF2a Metabolite lipidmaps:LMFA03010212
Tetranor-PGF2a Metabolite lipidmaps:LMFA03010213
Dinor-PGD2 Metabolite lipidmaps:LMFA03010214
Tetranor-PGD2 Metabolite lipidmaps:LMFA03010215
20-hydroxy-PGE2 Metabolite lipidmaps:LMFA03010014
20-hydroxy-PGF2a Metabolite lipidmaps:LMFA03010029
20-hydroxy-PGD2 Metabolite lipidmaps:LMFA03010216
15-deoxy-delta-12-PGJ2 Metabolite lipidmaps:LMFA03010021
TXA2 Metabolite lipidmaps:LMFA03030001
TXB2 Metabolite lipidmaps:LMFA03030002
11-dehydro-TXB2 Metabolite lipidmaps:LMFA03030004
12S-HHTrE Metabolite lipidmaps:LMFA03050002
15-keto-PGE2 Metabolite lipidmaps:LMFA03010030
15-keto-PGF2a Metabolite lipidmaps:LMFA03010026
15-keto-PGD2 Metabolite lipidmaps:LMFA03010206
13,14-dihydro-15-keto-PGE2 Metabolite lipidmaps:LMFA03010031
13,14-dihydro-15-keto-PGF2a Metabolite lipidmaps:LMFA03010027
13,14-dihydro-15-keto-PGD2 Metabolite lipidmaps:LMFA03010022
15(S)-HETE Metabolite lipidmaps:LMFA03060001
15(R)-HETE Metabolite lipidmaps:LMFA03060030
PTGIS GeneProduct ensembl:ENSG00000124212 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19223
TBXAS1 GeneProduct ensembl:ENSG00000059377 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21391
HPGD GeneProduct ensembl:ENSG00000164120 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
PLA2G5 Protein ensembl:ENSG00000127472 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18784
PPARD Protein ensembl:ENSG00000112033 AKA Peroxisome proliferator-activated receptor delta
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396
PLA2G6 Protein ensembl:ENSG00000184381 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53357
PLA2G4A Protein ensembl:ENSG00000116711 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18783
PLA2G4B Protein ensembl:ENSG00000243708 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:211429
PTGS1 Protein ensembl:ENSG00000095303 AKA COX-1
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19224
PTGS2 Protein ensembl:ENSG00000073756 AKA COX-2
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19225
PTGES Protein ensembl:ENSG00000148344 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64292
PTGDS Protein ensembl:ENSG00000107317 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19215
AKR1B1 Protein ensembl:ENSG00000085662 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11677
PTGR1 Protein ensembl:ENSG00000106853 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103
PTGR2 Protein ensembl:ENSG00000140043 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219
CYP4A11 Protein ensembl:ENSG00000187048 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
CYP4A22 Protein ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753
CYP4A22 Protein ensembl:ENSG00000162365 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
CYP4F12 Protein ensembl:ENSG00000186204 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
CYP4F2 Protein ensembl:ENSG00000186115 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
ACOX1 Protein ensembl:ENSG00000161533 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACOX2 Protein ensembl:ENSG00000168306 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
ACOX3 Protein ensembl:ENSG00000087008 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
ACAA1 Protein ensembl:ENSG00000060971 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
EHHADH Protein ensembl:ENSG00000113790 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
PTGIR Protein ensembl:ENSG00000160013 AKA Prostacyclin receptor, prostaglandin I2 receptor or just IP [https://en.wikipedia.org/wiki/Prostacyclin_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43252
PPAR gamma Protein uniprot:P37231 AKA Peroxisome proliferator-activated receptor gamma
PRXL2B Protein ensembl:ENSG00000157870 AKA Prxl2b
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9DB60
PTGFR Protein ensembl:ENSG00000122420 AKA Prostaglandin F receptor (FP) [https://en.wikipedia.org/wiki/Prostaglandin_F_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43117
PTGDR Protein ensembl:ENSG00000168229 AKA Prostaglandin D2 receptor 1 (DP1) [https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P70263
PTGDR2 Protein ensembl:ENSG00000183134 AKA Prostaglandin D2 receptor 2 (DP2 or CRTH2) [https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9Z2J6
TBXA2R Protein ensembl:ENSG00000006638 AKA thromboxane receptor (TP) also known as the prostanoid TP receptor [https://en.wikipedia.org/wiki/Thromboxane_receptor]
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P30987
PTGS1 Protein ensembl:ENSG00000095303 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P22437

References

  1. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Moreno JJ. Biochem Pharmacol. 2009 Jan 1;77(1):1–10. PubMed Europe PMC Scholia
  2. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  3. Eicosanoid storm in infection and inflammation. Dennis EA, Norris PC. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia