Eicosanoid metabolism via Cytochrome P450 Mono-Oxygenases (CYP) pathway (Mus musculus)

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1PPAR gammaEphx21Arachidonic acid16-HETE17-HETE1118-HETE119-HETE120-HETE15,6-EpETrE8,9-EpETrE1111,12-EpETrE114,15-EpETrE15,6-DiHETrE8,9-DiHETrE11,12-DiHETrE14,15-DiHETrECyp2c29Cyp2c37Cyp2c38Cyp2c39Cyp2c40Cyp2c44Cyp2c54Cyp2c55Cyp2j5Cyp4a10Cyp4a12aCyp4a12bCyp4f14Cyp4f18111PPAR alpha1


Description

This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [1] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [2]).

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX), lipooxygenases(LOX), or cytochrome P450 monooxygenases (CYP). This pathway visualises the third route, via CYP.

Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed

History

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CompareRevisionActionTimeUserComment
102925view12:53, 29 January 2019DeSlAdded another lit.ref
102914view12:01, 28 January 2019DeSlOntology Term : 'eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma' added !
102913view12:01, 28 January 2019DeSlModified description
102911view11:59, 28 January 2019DeSlAdded details from lit. ref
102910view11:52, 28 January 2019DeSlChanged layout
102908view10:59, 28 January 2019DeSlModified description
102895view16:21, 26 January 2019EgonwModified description
102888view15:47, 25 January 2019DeSlModified title
102884view15:46, 25 January 2019DeSlOntology Term : 'PW:0000002' removed !
102883view15:46, 25 January 2019DeSlOntology Term : 'cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism' added !
102882view15:45, 25 January 2019DeSlOntology Term : 'eicosanoid metabolic pathway' added !
102879view15:44, 25 January 2019DeSlModified description
102877view15:44, 25 January 2019DeSlModified description
98612view12:55, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98579view15:55, 17 September 2018EoinfahyNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11,12-DiHETrEMetaboliteLMFA03050008 (LIPID MAPS)
11,12-EpETrEMetaboliteLMFA03090010 (LIPID MAPS)
14,15-DiHETrEMetaboliteLMFA03050010 (LIPID MAPS)
14,15-EpETrEMetaboliteLMFA03080005 (LIPID MAPS)
16-HETEMetaboliteLMFA03090010 (LIPID MAPS)
17-HETEMetaboliteLMFA03060091 (LIPID MAPS)
18-HETEMetaboliteLMFA03060092 (LIPID MAPS)
19-HETEMetaboliteLMFA03060106 (LIPID MAPS)
20-HETEMetaboliteLMFA03060009 (LIPID MAPS)
5,6-DiHETrEMetaboliteLMFA03050004 (LIPID MAPS)
5,6-EpETrEMetaboliteLMFA03080002 (LIPID MAPS)
8,9-DiHETrEMetaboliteLMFA03050006 (LIPID MAPS)
8,9-EpETrEMetaboliteLMFA03080003 (LIPID MAPS)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Cyp2c29Protein13095 (Entrez Gene)
Cyp2c37Protein13096 (Entrez Gene)
Cyp2c38Protein13097 (Entrez Gene)
Cyp2c39Protein13098 (Entrez Gene)
Cyp2c40Protein13099 (Entrez Gene)
Cyp2c44Protein226143 (Entrez Gene)
Cyp2c54Protein404195 (Entrez Gene)
Cyp2c55Protein72082 (Entrez Gene)
Cyp2j5Protein13109 (Entrez Gene)
Cyp4a10GeneProduct13117 (Entrez Gene)
Cyp4a12aGeneProduct277753 (Entrez Gene)
Cyp4a12bGeneProduct13118 (Entrez Gene)
Cyp4f14GeneProduct64385 (Entrez Gene)
Cyp4f18GeneProduct72054 (Entrez Gene)
Ephx2GeneProduct13850 (Entrez Gene)
PPAR alphaProteinP23204 (Uniprot-TrEMBL) AKA Peroxisome proliferator-activated receptor alpha
PPAR gammaProteinP37238 (Uniprot-TrEMBL) AKA Peroxisome proliferator-activated receptor gamma

Annotated Interactions

No annotated interactions

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