Peroxiredoxin 2 induced ovarian failure (WP4835)

Mus musculus

This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.


Bas Lahaije , Laurent Winckers , Friederike Ehrhart , and Egon Willighagen


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus


Rare Diseases


Pathway Ontology

signaling pathway c-Jun N-terminal kinases MAPK signaling pathway

Disease Ontology

ovarian dysfunction


Label Type Compact URI Comment
Reactive oxygen species Metabolite chebi:26523
Estradiol-17beta Metabolite chebi:16469
Progesterone Metabolite chebi:17026
PARP Metabolite chebi:62913
Bax GeneProduct ensembl:ENSMUSG00000003873
Cytochrome c Protein uniprot:P62897 Somatic
CYP11A1 Protein uniprot:Q9QZ82 Mitochondrial
3Beta-HSD Protein uniprot:E9PXG7
JNK Protein ensembl:ENSMUSP00000023291
Caspase-3 Protein uniprot:A0A1B0GRX1
StAR Protein uniprot:P51557 Mitichondrial
Type your comment here
Peroxiredoxin-2 Protein uniprot:Q61171


  1. Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS. Free Radic Biol Med. 2018 Aug 1;123:96–106. PubMed Europe PMC Scholia