This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.
b22
Somatic
Mitochondrial
Mitichondrial
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signaling pathway
PW:0000003
Pathway Ontology
ovarian dysfunction
DOID:1414
Human Disease Ontology
c-Jun N-terminal kinases MAPK signaling pathway
PW:0000313
Pathway Ontology
29778464
PubMed
Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.
Free Radic Biol Med
2018
Park SJ
Kim JH
Lee DG
Kim JM
Lee DS