Omega-3 / omega-6 fatty acid synthesis (WP4723)
Homo sapiens
This pathway is inspired by the Lipidmaps>Omega-3 and omega-6 fatty acids) [1]. Omega-3 and omega-6 FAs (Fatty acids) are important fats obtained from diet, and are both polyunsaturated (indicating many double bonds in the lipid tail).The position of the double bond is given in the name of the lipid, for example 22:2(13Z,16Z) means a tail length of 22 carbons, with 2 double bond. One double bond is at the 13 Carbon, the second on the 16th.This number is counted from the tail end of the lipid chain (indicating that the example lipid is a 22 - 16 = omega-6 FA).
For a description of pathway objects, see the WikiPathways Legend.
Authors
Denise Slenter , Egon Willighagen , Eric Weitz , Matthew Conroy , and Daniela DiglesActivity
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPS ONTOXAnnotations
Pathway Ontology
amino acid metabolic pathway fatty acid elongation pathway fatty acid metabolic pathway fatty acid omega degradation pathway unsaturated fatty acid biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Glycerophospholipids | Metabolite | chebi:37739 | |
| Arachidonic acid | Metabolite | lipidmaps:LMFA01030001 | |
| Linoleic acid | Metabolite | lipidmaps:LMFA01030120 | |
| CoA(18:2(9Z,12Z)) | Metabolite | lipidmaps:LMFA07050343 | |
| CoA(18:3(6Z,9Z,12Z)) | Metabolite | lipidmaps:LMFA07050322 | |
| CoA(20:2(11Z,14Z)) | Metabolite | lipidmaps:LMFA07050036 | |
| CoA(20:3(8Z,11Z,14Z)) | Metabolite | lipidmaps:LMFA07050278 | |
| Arachidonoyl-CoA | Metabolite | lipidmaps:LMFA07050288 | aka CoA(20:4) |
| gamma-Linolenic acid | Metabolite | lipidmaps:LMFA01030141 | |
| CoA(22:4) | Metabolite | lipidmaps:LMFA07050129 | |
| CoA(24:4) | Metabolite | lipidmaps:LMFA07050139 | |
| 20:2(11Z,14Z) | Metabolite | lipidmaps:LMFA01031043 | aka 11,14-eicosadienoic acid |
| Bishomo-gamma-linolenic acid | Metabolite | lipidmaps:LMFA01030158 | |
| CoA(22:5(4Z,7Z,10Z,13Z,16Z)) | Metabolite | lipidmaps:LMFA07050043 | |
| alpha-Linolenic acid | Metabolite | lipidmaps:LMFA01030152 | |
| CoA(18:3(9Z,12Z,15Z)) | Metabolite | lipidmaps:LMFA07050286 | |
| CoA(18:4(6Z,9Z,12Z,15Z)) | Metabolite | lipidmaps:LMFA07050123 | |
| CoA(20:4(8Z,11Z,14Z,17Z)) | Metabolite | lipidmaps:LMFA07050134 | |
| CoA(20:5) | Metabolite | lipidmaps:LMFA07050122 | |
| CoA(22:5(7Z,10Z,13Z,16Z,19Z)) | Metabolite | lipidmaps:LMFA07050131 | |
| CoA(22:6) | Metabolite | lipidmaps:LMFA07050121 | |
| CoA(24:5(9Z,12Z,15Z,18Z,21Z)) | Metabolite | lipidmaps:LMFA07050141 | |
| CoA(24:6) | Metabolite | lipidmaps:LMFA07050127 | |
| DHA | Metabolite | lipidmaps:LMFA01030185 | |
| 24:6(6Z,9Z,12Z,15Z,18Z,21Z) | Metabolite | lipidmaps:LMFA01030822 | |
| 24:5(9Z,12Z,15Z,18Z,21Z) | Metabolite | lipidmaps:LMFA01030821 | |
| 22:5(7Z,10Z,13Z,16Z,19Z) | Metabolite | lipidmaps:LMFA04000044 | |
| 20:5(5Z,8Z,11Z,14Z,17Z) | Metabolite | lipidmaps:LMFA01030759 | |
| 20:4(8Z,11Z,14Z,17Z) | Metabolite | lipidmaps:LMFA01030818 | |
| Stearidonic acid | Metabolite | lipidmaps:LMFA01030357 | aka 5,8,11,14,17-eicosapentaenoic acid |
| 22:5(4Z,7Z,10Z,13Z,16Z) | Metabolite | lipidmaps:LMFA04000064 | |
| 22:4(7Z,10Z,13Z,16Z) | Metabolite | lipidmaps:LMFA01030178 | |
| 24:4(9Z,12Z,15Z,18Z) | Metabolite | lipidmaps:LMFA01030819 | |
| CoA(22:2(13Z,16Z)) | Metabolite | lipidmaps:LMFA07050037 | |
| 22:2(13Z,16Z) | Metabolite | lipidmaps:LMFA01030405 | aka 13,16-docodadienoic acid |
| CoA(20:3(11Z,14Z,17Z)) | Metabolite | lipidmaps:LMFA07050044 | |
| 20:3(11Z,14Z,17Z) | Metabolite | lipidmaps:LMFA01030378 | AKA 11,14,17-eicosatrienoic acid |
| CoA(24:5(6Z,9Z,12Z,15Z,18Z)) | Metabolite | lipidmaps:LMFA07050042 | |
| 24:5(6Z,9Z,12Z,15Z,18Z) | Metabolite | lipidmaps:LMFA01030820 | |
| FADS2 | GeneProduct | ensembl:ENSG00000134824 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 |
| ACSL1 | GeneProduct | ensembl:ENSG00000151726 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081 |
| ACSL3 | GeneProduct | ensembl:ENSG00000123983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205 |
| ACSL4 | GeneProduct | ensembl:ENSG00000068366 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 |
| ELOVL2 | GeneProduct | ensembl:ENSG00000197977 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326 |
| ELOVL5 | GeneProduct | ensembl:ENSG00000012660 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801 |
| FADS1 | GeneProduct | ensembl:ENSG00000149485 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267 |
| ACOX1 | GeneProduct | ensembl:ENSG00000161533 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430 |
| ACOX3 | GeneProduct | ensembl:ENSG00000087008 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 |
| ACOT1 | GeneProduct | uniprot:Q86TX2 | No homologues found for original id L:26897 |
| ACOT2 | GeneProduct | ensembl:ENSG00000119673 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210 |
| PLA2G5 | Protein | ensembl:ENSG00000127472 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18784 |
| PLA2G6 | Protein | ensembl:ENSG00000184381 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53357 |
| PLA2G4A | Protein | ensembl:ENSG00000116711 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18783 |
| PLA2G4B | Protein | ensembl:ENSG00000243708 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:211429 |
References
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia