Acetate mediated promotion of metabolic syndrome (WP3650)
Acetates produced by gut microbes stimulates the parasympathetic nervous system which causes in an increase in the release of the gastrin hormone which triggers insulin release from beta-cells. Prolonged exposure to high acetate levels promote a state of metabolic syndrome.
AuthorsEgon Willighagen , Kristina Hanspers , Anders Riutta , and Denise Slenter
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Cell Type OntologyB cell parasympathetic neuron
Disease Ontologyacquired metabolic disease
Pathway Ontologydisease pathway