Acetate mediated promotion of metabolic syndrome (WP3650)

Rattus norvegicus

Acetates produced by gut microbes stimulates the parasympathetic nervous system which causes in an increase in the release of the gastrin hormone which triggers insulin release from beta-cells. Prolonged exposure to high acetate levels promote a state of metabolic syndrome.


Egon Willighagen , Kristina Hanspers , Anders Riutta , and Denise Slenter


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Rattus norvegicus



Cell Type Ontology

B cell parasympathetic neuron

Disease Ontology

acquired metabolic disease

Pathway Ontology

disease pathway


Label Type Compact URI Comment
fatty acid Metabolite chebi:35366
acetate Metabolite chebi:30089
glucose Metabolite chebi:17634
fatty acid Metabolite chebi:35366
acetate Metabolite chebi:30089
gastrin Protein uniprot:P04563
insulin Protein uniprot:P01323


  1. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, et al. Nature. 2016 Jun 9;534(7606):213–7. PubMed Europe PMC Scholia