SK UDPglcnac (WP3641)

Escherichia coli

"Escherichia coli (E. Coli) contains a specific acyltransferase that derivatizes UDP-GlcNAc, which is the first obligatory reaction in the formation of lipid A (1-3), a unique glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of gramnegative bacteria." (rephrased from Anderson et al (1993)[] ).


Skrekels , Linda Rieswijk , Egon Willighagen , Denise Slenter , and Lars Willighagen


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Escherichia coli



Pathway Ontology

glucose transport pathway peptidoglycan biosynthetic pathway

Disease Ontology

glucose metabolism disease


Label Type Compact URI Comment
N-acetylglucosamine-6P Metabolite wikidata:Q27098230
peptidoglycan Metabolite chebi:8005
N-acetylglucosamine Metabolite wikidata:Q27225758
Glycerol-3P Metabolite chebi:26706 Added CheBI-group as ID
Glucosamine-6P Metabolite wikidata:Q55168356
Acetyl-CoA Metabolite chebi:15351
Glucosamine-1P Metabolite hmdb:HMDB0001109
N-acetylglucosamine-1-P Metabolite chebi:16446
N-Acetylglucosamine Metabolite chebi:506227
GlcNAc Metabolite chebi:506227
GlcNAc-1P Metabolite chebi:16446
UDP-N-acetylglucosamine Metabolite chebi:16264
N-acetylglucosamine Metabolite wikidata:Q27225758
glucose Metabolite chebi:17234
Glycerol Metabolite chebi:17754
Glycerol Metabolite chebi:17754
Glycerol Metabolite chebi:17754
Glucose Metabolite chebi:17234
Glucose-6P Metabolite wikidata:Q32778969
Fructose-6P Metabolite chebi:15946
UTP Metabolite chebi:46398
Glutamine Metabolite wikidata:Q181619
ATP Metabolite chebi:15422
ATP Metabolite chebi:15422
ATP Metabolite chebi:15422
ATP Metabolite chebi:15422
Acetate Metabolite wikidata:Q212527
UTP Metabolite chebi:46398
UDP-GlcNAc Metabolite chebi:16264
glmU GeneProduct ensembl:b3730
pgi GeneProduct ensembl:b4025
glpK GeneProduct ensembl:b3926
nagZ GeneProduct ensembl:b1107
glmS GeneProduct ensembl:b3729
nagA GeneProduct ensembl:b0677
murG GeneProduct ensembl:b0090
glmM GeneProduct ensembl:b3176
ompF GeneProduct ensembl:b0929
glpF GeneProduct ensembl:b3927
ptsG GeneProduct ensembl:b1101
nagE GeneProduct ensembl:b0679
ftsW GeneProduct ensembl:b0089
murA GeneProduct ensembl:b3189
ampG GeneProduct ensembl:b0433
nagB GeneProduct ensembl:b0678
murJ GeneProduct ensembl:b1069
GlmU Protein ensembl:b3730
NagK Protein uniprot:P75959
OmpF Protein ensembl:b0929


  1. UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable. Anderson MS, Bull HG, Galloway SM, Kelly TM, Mohan S, Radika K, et al. J Biol Chem. 1993 Sep 15;268(26):19858–65. PubMed Europe PMC Scholia
  2. FtsW activity and lipid II synthesis are required for recruitment of MurJ to midcell during cell division in Escherichia coli. Liu X, Meiresonne NY, Bouhss A, den Blaauwen T. Mol Microbiol. 2018 Sep;109(6):855–84. PubMed Europe PMC Scholia