Lung fibrosis (WP3624)

Homo sapiens

Lung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Friederike Ehrhart , Penny Nymark , Linda Rieswijk , Kristina Hanspers , Jonathan Mélius , Egon Willighagen , and Martina Summer-Kutmon


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Homo sapiens


Adverse Outcome Pathways Diseases Nanomaterials Pathways


Disease Ontology

pulmonary fibrosis

Pathway Ontology

respiratory system disease pathway carbon nanotube response pathway


Label Type Compact URI Comment
ROSproduction Metabolite chebi:26523
ROSproduction Metabolite chebi:26523
ELMOD2 GeneProduct ensembl:ENSG00000179387
RTEL1 GeneProduct ensembl:ENSG00000258366
CXCL2 GeneProduct ensembl:ENSG00000081041
SPP1 GeneProduct ensembl:ENSG00000118785
DPP9 GeneProduct ensembl:ENSG00000142002
FGF1 GeneProduct ensembl:ENSG00000113578
CCL4 GeneProduct ensembl:ENSG00000275302
SMAD7 GeneProduct ensembl:ENSG00000101665
TERC GeneProduct ensembl:ENSG00000270141
CTGF GeneProduct ensembl:ENSG00000118523
SFTPA2 GeneProduct ensembl:ENSG00000185303
PARN GeneProduct ensembl:ENSG00000140694
CCL2 GeneProduct ensembl:ENSG00000108691
SERPINA1 GeneProduct ensembl:ENSG00000197249
SKIL GeneProduct ensembl:ENSG00000136603
TNF GeneProduct ensembl:ENSG00000232810
SFTPA1 GeneProduct ensembl:ENSG00000122852
IL6 GeneProduct ensembl:ENSG00000136244
EDN1 GeneProduct ensembl:ENSG00000078401
ELN GeneProduct ensembl:ENSG00000049540
CSF3 GeneProduct ensembl:ENSG00000108342
GREM1 GeneProduct ensembl:ENSG00000166923
DSP GeneProduct ensembl:ENSG00000096696
TERT GeneProduct ensembl:ENSG00000164362
MECP2 GeneProduct ensembl:ENSG00000169057
CXCL8 GeneProduct ensembl:ENSG00000169429
OBFC1 GeneProduct ensembl:ENSG00000107960
CALCA GeneProduct ensembl:ENSG00000110680
TGFA GeneProduct ensembl:ENSG00000163235
IL13 GeneProduct ensembl:ENSG00000169194
IL1B GeneProduct ensembl:ENSG00000125538
CCR3 GeneProduct ensembl:ENSG00000183625
CCL5 GeneProduct ensembl:ENSG00000271503
PDGFA GeneProduct ensembl:ENSG00000197461
CCL11 GeneProduct ensembl:ENSG00000172156
ATP11A GeneProduct ensembl:ENSG00000068650
FGF2 GeneProduct ensembl:ENSG00000138685
CMA1 GeneProduct ensembl:ENSG00000092009
IL5 GeneProduct ensembl:ENSG00000113525
EGF GeneProduct ensembl:ENSG00000138798
TIMP1 GeneProduct ensembl:ENSG00000102265
IL12B GeneProduct ensembl:ENSG00000113302
BMP7 GeneProduct ensembl:ENSG00000101144
PDGFB GeneProduct ensembl:ENSG00000100311
PTX3 GeneProduct ensembl:ENSG00000163661
NFE2L2 GeneProduct ensembl:ENSG00000116044
MMP9 GeneProduct ensembl:ENSG00000100985
FGF7 GeneProduct ensembl:ENSG00000140285
MUC5B GeneProduct ensembl:ENSG00000117983
CEBPB GeneProduct ensembl:ENSG00000172216
CYSLTR2 GeneProduct ensembl:ENSG00000152207
HMOX1 GeneProduct ensembl:ENSG00000100292
MMP2 GeneProduct ensembl:ENSG00000087245
HGF GeneProduct ensembl:ENSG00000019991
SFTPC GeneProduct ensembl:ENSG00000168484
CCR2 GeneProduct ensembl:ENSG00000121807
IL4 GeneProduct ensembl:ENSG00000113520
CSF2 GeneProduct ensembl:ENSG00000164400
PLAU GeneProduct ensembl:ENSG00000122861
FAM13A GeneProduct ensembl:ENSG00000138640
CCL3 GeneProduct ensembl:ENSG00000277632
MT2A GeneProduct ensembl:ENSG00000125148
IGF1 GeneProduct ensembl:ENSG00000017427
TGFB1 GeneProduct ensembl:ENSG00000105329


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