Overview of nanoparticle effects (WP3287)

Homo sapiens

This pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle-specific effect known, there is a cascade of effects triggered if cells or organisms are exposed to nanoparticles: The most abundantly observed event is oxidative stress which causes DNA damage, protein and lipid oxidation, and cell death. The mere overload of nanoparticles in the vesicular system leads to cytoskeleton and cell adhesion problems and interfere with the cell's autophagic system. Some specific nanoparticles are reported to interfere with the cell membrane, others stimulate the blood coagulation system. The release of metal ions from specific nanoparticles challenges the metal disposal system of the cell.


Friederike Ehrhart , Martina Summer-Kutmon , Linda Rieswijk , Egon Willighagen , and Eric Weitz


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Homo sapiens


Adverse Outcome Pathways Nanomaterials Pathways


Pathway Ontology

nanomaterial response pathway


Label Type Compact URI Comment
Glutathione Metabolite chebi:16856
Nanoparticle Metabolite chebi:50803
Prostaglandin Metabolite chebi:26333
AKT GeneProduct ensembl:ENSG00000117020
ferritin GeneProduct pfam:PF00210
C-reactive protein GeneProduct ensembl:ENSG00000132693
COX2 (PTGS2) GeneProduct ensembl:ENSG00000073756
PI3K GeneProduct ensembl:ENSG00000171608
Integrin GeneProduct ensembl:ENSG00000156886
HMOX1 GeneProduct ensembl:ENSG00000100292
FAK (PTK2) GeneProduct ensembl:ENSG00000169398
Metallothionein GeneProduct pfam:PF00131
COX1 (PTGS1) GeneProduct ensembl:ENSG00000095303
Actin GeneProduct pfam:PF00022
P-cadherin GeneProduct ensembl:ENSG00000062038
fibronectin GeneProduct ensembl:ENSG00000115414
collagen IV GeneProduct ensembl:ENSG00000187498
NF-kB GeneProduct ensembl:ENSG00000170322
Bax GeneProduct ensembl:ENSG00000087088
IL-6 GeneProduct ensembl:ENSG00000136244
Il-8 GeneProduct ensembl:ENSG00000169429
Bcl-2 GeneProduct ensembl:ENSG00000171791
TNF GeneProduct ensembl:ENSG00000232810
cyclin D3 GeneProduct ensembl:ENSG00000112576
laminin GeneProduct ensembl:ENSG00000053747


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