Nanoparticle triggered autophagic cell death (WP2509)
Programmed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can result in genetically programmed cell death. Carbon nanotubes, PAMAMs, and iron oxide nanoparticles were reported to trigger autophagic cell death through the perturbation of the mTOR pathway, while gold nanoparticles may induce autophagy blockade through lysosomal impairment.
AuthorsEgon Willighagen , Andra Waagmeester , Bart Smeets , and Friederike Ehrhart
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CommunitiesAdverse Outcome Pathways Nanomaterials Pathways
Pathway Ontologynanomaterial response pathway
- PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, et al. J Mol Cell Biol. 2009 Oct;1(1):37–45. PubMed Europe PMC Scholia
- A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling. Liu HL, Zhang YL, Yang N, Zhang YX, Liu XQ, Li CG, et al. Cell Death Dis. 2011 May 19;2(5):e159. PubMed Europe PMC Scholia
- Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. Ma X, Wu Y, Jin S, Tian Y, Zhang X, Zhao Y, et al. ACS Nano. 2011 Nov 22;5(11):8629–39. PubMed Europe PMC Scholia
- Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. Khan MI, Mohammad A, Patil G, Naqvi SAH, Chauhan LKS, Ahmad I. Biomaterials. 2012 Feb;33(5):1477–88. PubMed Europe PMC Scholia
- Programmed cell death: molecular mechanisms and implications for safety assessment of nanomaterials. Andón FT, Fadeel B. Acc Chem Res. 2013 Mar 19;46(3):733–42. PubMed Europe PMC Scholia