Methylerythritol phosphate pathway (WP2212)

Oryza sativa

In plants, the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway located in the plastids provides precursors for the isoprenoid hormones, monoterpenes, carotenoids and chlorophyll side chains, prenylquinones and tocopherol biosynthesis.

Authors

Pankaj Jaiswal , Egon Willighagen , Martina Summer-Kutmon , and Denise Slenter

Activity

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Cited In

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Organisms

Oryza sativa

Communities

Annotations

Cell Type Ontology

obsolete plant cell

Pathway Ontology

tetrahydrobiopterin metabolic pathway

Participants

Label Type Compact URI Comment
1-deoxy-D-xylulose 5-phosphate Metabolite kegg.compound:C11437
NADPH Metabolite cas:53-57-6
ADP Metabolite cas:58-64-0
ATP Metabolite cas:56-65-5
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol Metabolite chebi:16840
2-C-methyl-D-erythritol-4-phosphate Metabolite kegg.compound:C11434
CTP Metabolite cas:65-47-4
pyruvate Metabolite cas:127-17-3
H2O Metabolite cas:7732-18-5
diphosphate Metabolite cas:2466-09-3
Δ3-isopentenyl-PP Metabolite kegg.compound:C00129
NADP+ Metabolite cas:53-59-8
dimethylallyl-PP Metabolite cas:358-71-4
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate Metabolite kegg.compound:C11811
2-C-methyl-D-erythritol-2,4-cyclodiphosphate Metabolite kegg.compound:C11453
CO2 Metabolite cas:124-38-9
CMP Metabolite cas:63-37-6
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol Metabolite kegg.compound:C11435
D-glyceraldehyde-3-phosphate Metabolite cas:591-57-1
NAD(P)+ Metabolite cas:53-59-8
NAD(P)H Metabolite chebi:13392
H+ Metabolite cas:12408-02-5
EC:1.17.1.2 GeneProduct eccode:1.17.1.2
LOC_Os07g36190 GeneProduct :LOC_Os07g36190 hydrolase, NUDIX family, domain containing protein, expressed//isopentenyl-diphosphate delta-isomerase
LOC_Os05g33840 GeneProduct :LOC_Os05g33840 transketolase, putative, expressed//terpenoid biosynthetic process//1-deoxy-D-xylulose-5-phosphate synthase//transketolase
EC:2.2.1.7 GeneProduct eccode:2.2.1.7
LOC_Os01g66360 GeneProduct :LOC_Os01g66360 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative, expressed//terpenoid biosynthetic process//4-diphosphocytidyl-2C-methyl-D-erythritol synthase
EC:5.3.3.2 GeneProduct eccode:5.3.3.2
LOC_Os02g45660 GeneProduct :LOC_Os02g45660 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplast precursor, putative, expressed//terpenoid biosynthetic process//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
EC:1.17.4.3 GeneProduct eccode:1.17.4.3
LOC_Os03g52170 GeneProduct :LOC_Os03g52170 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative, expressed//terpenoid biosynthetic process
LOC_Os01g01710 GeneProduct :LOC_Os01g01710 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplast precursor, putative, expressed//isoprenoid biosynthetic process//catalytic activity//1-deoxy-D-xylulose-5-phosphate reductoisomerase
LOC_Os07g40260 GeneProduct :LOC_Os07g40260 eukaryotic aspartyl protease domain containing protein, expressed
EC:1.1.1.267 GeneProduct eccode:1.1.1.267
EC:2.7.1.148 GeneProduct eccode:2.7.1.148
LOC_Os02g39160 GeneProduct :LOC_Os02g39160 hydroxymethylbutenyl 4-diphosphate synthase, putative, expressed//terpenoid biosynthetic process//sugar:hydrogen symporter activity//phosphoenolpyruvate-dependent sugar phosphotransferase system//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
LOC_Os05g34180 GeneProduct :LOC_Os05g34180 hydrolase, NUDIX family, domain containing protein, expressed//isoprenoid biosynthetic process//terpenoid biosynthetic process//isopentenyl-diphosphate delta-isomerase
LOC_Os07g09190 GeneProduct :LOC_Os07g09190 transketolase, putative, expressed//terpenoid biosynthetic process
EC:2.7.7.60 GeneProduct eccode:2.7.7.60
EC:4.6.1.12 GeneProduct eccode:4.6.1.12
LOC_Os06g05100 GeneProduct :LOC_Os06g05100 transketolase, putative, expressed//terpenoid biosynthetic process//1-deoxy-D-xylulose-5-phosphate synthase
LOC_Os01g58790 GeneProduct :LOC_Os01g58790 GHMP kinases ATP-binding protein, putative, expressed//ATP binding//terpenoid biosynthetic process//4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

References