Oryzalexin S biosynthesis (WP2210)

Oryza sativa

In rice diterpenoid phytoalexins are produced in response to exogenously applied elicitors. Oryzalexin S is one of those phytoalexin.


Pankaj Jaiswal , Egon Willighagen , and Denise Slenter


last edited

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Oryza sativa



Pathway Ontology

diterpenoid biosynthetic pathway

Cell Type Ontology

obsolete plant cell


Label Type Compact URI Comment
Diphosphate Metabolite chebi:18361
syn-copalyl diphosphate Metabolite chebi:29739
stemar-13-ene Metabolite chebi:50069
oryzalexin S Metabolite hmdb:HMDB0039687
LOC_Os11g28530 (KS8/DTC2/stemar-13-ene synthase) GeneProduct :LOC_Os11g28530 terpene synthase, putative, expressed//stemar-13-ene synthase activity//lyase activity//metabolic process//diterpene phytoalexin metabolic process//ent-kaurene synthase
EC: GeneProduct eccode: stemar-13-ene synthase


  1. Biosynthesis of cyclic diterpene hydrocarbons in rice cell suspensions: conversion of 9,10-syn-labda-8(17),13-dienyl diphosphate to 9beta-pimara-7,15-diene and stemar-13-ene. Mohan RS, Yee NK, Coates RM, Ren YY, Stamenkovic P, Mendez I, et al. Arch Biochem Biophys. 1996 Jun 1;330(1):33–47. PubMed Europe PMC Scholia
  2. Stemar-13-ene synthase, a diterpene cyclase involved in the biosynthesis of the phytoalexin oryzalexin S in rice. Nemoto T, Cho EM, Okada A, Okada K, Otomo K, Kanno Y, et al. FEBS Lett. 2004 Jul 30;571(1–3):182–6. PubMed Europe PMC Scholia
  3. Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis. Otomo K, Kenmoku H, Oikawa H, König WA, Toshima H, Mitsuhashi W, et al. Plant J. 2004 Sep;39(6):886–93. PubMed Europe PMC Scholia
  4. Promoter analysis of the rice stemar-13-ene synthase gene OsDTC2, which is involved in the biosynthesis of the phytoalexin oryzalexin S. Nemoto T, Okada A, Okada K, Shibuya N, Toyomasu T, Nojiri H, et al. Biochim Biophys Acta. 2007;1769(11–12):678–83. PubMed Europe PMC Scholia
  5. Recent advances regarding diterpene cyclase genes in higher plants and fungi. Toyomasu T. Biosci Biotechnol Biochem. 2008 May;72(5):1168–75. PubMed Europe PMC Scholia