daf-2 or insulin signaling pathway (WP17)

Caenorhabditis elegans

Insulin receptor pathway in C. elegans Initial version based on review by [https://www.ncbi.nlm.nih.gov/pubmed/16441841 Gami and Wolkow] of pathways that affect ageing. The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. C. elegans with a diet of low glucose, reduced Daf-16 activity and worms lifespan was shortened compared to worms fed on media without glucose.


Martijn Van Iersel , Pieter Giesbertz , Christine Chichester , Christian Grove , Karen Yook , Asios Olia , and Kristina Hanspers


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Caenorhabditis elegans




Pathway Ontology

aging pathway insulin-like growth factor signaling pathway


Label Type Compact URI Comment
PIP Metabolite hmdb:HMDB0004249
SGK-1 GeneProduct wormbase:W10G6.2
AKT-1 GeneProduct wormbase:C12D8.10
PDK-1 GeneProduct wormbase:H42K12.1
DAF-2/INSR GeneProduct wormbase:Y55D5A.5
DAF-18/PTEN GeneProduct wormbase:T07A9.6
AKT-2 GeneProduct wormbase:F28H6.1
AGE-1/PI-3K GeneProduct wormbase:B0334.8
DAF-16/FOXO GeneProduct wormbase:R13H8.1


  1. Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan. Gami MS, Wolkow CA. Aging Cell. 2006 Feb;5(1):31–7. PubMed Europe PMC Scholia