Insulin receptor pathway in C. elegans
Initial version based on review by [https://www.ncbi.nlm.nih.gov/pubmed/16441841 Gami and Wolkow] of pathways that affect ageing.
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans.
C. elegans with a diet of low glucose, reduced Daf-16 activity and worms lifespan was shortened compared to worms fed on media without glucose.d4daging pathwayPW:0000651Pathway Ontologyinsulin-like growth factor signaling pathwayPW:0000238Pathway Ontology16441841PubMedStudies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan.Aging Cell2006Gami MSWolkow CA