Eukaryotic transcription initiation (WP1238)

Anopheles gambiae

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: [[wikipedia:Transcription_(genetics)|Wikipedia]]


Thomas Kelder , Anwesha Bohler , Christine Chichester , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Anopheles gambiae



Pathway Ontology

transcription pathway


Label Type Compact URI Comment
AgaP_AGAP010958 GeneProduct ncbigene:1271006
AgaP_AGAP009558 GeneProduct ncbigene:1271351
AgaP_AGAP011678 GeneProduct ncbigene:1280962
AgaP_AGAP004254 GeneProduct ncbigene:1274098
AgaP_AGAP010493 GeneProduct ncbigene:1275232
AgaP_AGAP003094 GeneProduct ncbigene:1273770
AgaP_AGAP006573 GeneProduct ncbigene:1277157
AgaP_AGAP003135 GeneProduct ncbigene:1273807
AgaP_AGAP008045 GeneProduct ncbigene:1277907
AgaP_AGAP006355 GeneProduct ncbigene:1276961
AgaP_AGAP004370 GeneProduct ncbigene:1274516
AgaP_AGAP007002 GeneProduct ncbigene:1270098
AgaP_AGAP005382 GeneProduct ncbigene:1276084
AgaP_AGAP002646 GeneProduct ncbigene:1273315
AgaP_AGAP011110 GeneProduct ncbigene:1270814
AgaP_AGAP010559 GeneProduct ncbigene:1275295
AgaP_AGAP010984 GeneProduct ncbigene:1270972
AgaP_AGAP012169 GeneProduct ncbigene:1280516
AgaP_AGAP002988 GeneProduct ncbigene:1272969
AgaP_AGAP009539 GeneProduct ncbigene:1271371
AgaP_AGAP008151 GeneProduct ncbigene:1277811
AgaP_AGAP007810 GeneProduct ncbigene:1278148
AgaP_AGAP005873 GeneProduct ncbigene:1276540
AgaP_AGAP010321 GeneProduct ncbigene:1278625
AgaP_AGAP010064 GeneProduct ncbigene:1279496
AgaP_AGAP004480 GeneProduct ncbigene:3291022
AgaP_AGAP005922 GeneProduct ncbigene:1276589
AgaP_AGAP012122 GeneProduct ncbigene:1280555
AgaP_AGAP008393 GeneProduct ncbigene:1277585
AgaP_AGAP002121 GeneProduct ncbigene:1281372
AgaP_AGAP012397 GeneProduct ncbigene:1280317
AgaP_AGAP009209 GeneProduct ncbigene:1280168
AgaP_AGAP003648 GeneProduct ncbigene:1274316
AgaP_AGAP008417 GeneProduct ncbigene:1277560
AgaP_AGAP008991 GeneProduct ncbigene:1279954
AgaP_AGAP008522 GeneProduct ncbigene:1277449
AgaP_AGAP001792 GeneProduct ncbigene:1281323