Cell cycle (WP1200)

Canis familiaris

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


Martijn Van Iersel , Martina Summer-Kutmon , and Lauren J. Dupuis


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Canis familiaris



Pathway Ontology

cell cycle pathway


Label Type Compact URI Comment
PTTG1 GeneProduct ncbigene:479307 PTTG1; pituitary tumor-transforming
CDKN2A GeneProduct ncbigene:100271861
YWHAG GeneProduct ncbigene:489818 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
CDK6 GeneProduct ncbigene:609920 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CCNA2 GeneProduct ncbigene:483845 CCNA2; cyclin A2
CDC20 GeneProduct ncbigene:482534 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
MPEG1 GeneProduct ncbigene:475960
CCNE2 GeneProduct ncbigene:487057 CCNE2; cyclin E
CDC25B GeneProduct ncbigene:485790 CDC25B; cell division cycle 25B [EC:]
ORC4L GeneProduct ncbigene:476141 ORC4L; origin recognition complex subunit 4-like (yeast)
RB1 GeneProduct ncbigene:476915 RB1; retinoblastoma 1 (including osteosarcoma)
TBC1D8 GeneProduct ncbigene:474551
LOC607662 GeneProduct ncbigene:607662 HDAC4; histone deacetylase 4
CCND2 GeneProduct ncbigene:611782 CCND2; cyclin D2
PRKDC GeneProduct ncbigene:474176 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:]
SMC1A GeneProduct ncbigene:480928 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
ORC3L GeneProduct ncbigene:474991 ORC3L; origin recognition complex subunit 3-like (yeast)
BUB3 GeneProduct ncbigene:477857 BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CHEK2 GeneProduct ncbigene:486338 CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
LOC486589 GeneProduct ncbigene:486589 HDAC7A; histone deacetylase 7
RB1 GeneProduct ncbigene:476915 RB1; retinoblastoma 1 (including osteosarcoma)
MDM2 GeneProduct ncbigene:403693 MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MCM7 GeneProduct ncbigene:479737 MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
CDC14A GeneProduct ncbigene:479926 CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
LOC480957 GeneProduct ncbigene:480957 HDAC8; histone deacetylase
CCNH GeneProduct ncbigene:479156 CCNH; cyclin H
ESPL1 GeneProduct ncbigene:607879 ESPL1; extra spindle poles like 1 (S. cerevisiae
LOC487309 GeneProduct ncbigene:487309 HDAC1; histone deacetylase 1
CDKN1B GeneProduct ncbigene:403429 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
RBL1 GeneProduct ncbigene:477221
MAD2L1 GeneProduct ncbigene:476070 MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
CCNB2 GeneProduct ncbigene:478324 CCNB2; cyclin B2
CDK2 GeneProduct ncbigene:606931 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
LOC490941 GeneProduct ncbigene:490941 HDAC5; histone deacetylase 5
UBE2F GeneProduct ncbigene:477421 UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
BUB1B GeneProduct ncbigene:608350 BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
ORC1L GeneProduct ncbigene:475351 ORC1L; origin recognition complex subunit 1-like (yeast)
LOC480907 GeneProduct ncbigene:480907 HDAC6; histone deacetylase 6
MAD1L1 GeneProduct ncbigene:609673 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
SMAD3 GeneProduct ncbigene:610902 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
CDC45L GeneProduct ncbigene:486421 CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CCNE1 GeneProduct ncbigene:484610 CCNE1; cyclin E
CCNB3 GeneProduct ncbigene:449494 CCNB3; cyclin B
CCNA2 GeneProduct ncbigene:483845 CCNA2; cyclin A2
TFDP1 GeneProduct ncbigene:607720 TFDP1; transcription factor Dp-1
E2F3 GeneProduct ncbigene:488239 E2F3; E2F transcription factor 3
WEE1 GeneProduct ncbigene:476847 WEE1; WEE1+ homolog (S. pombe) [EC:]
CDK2 GeneProduct ncbigene:606931 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDH1 GeneProduct ncbigene:442858
CCND3 GeneProduct ncbigene:608847 CCND3; cyclin D3
TGFB1 GeneProduct ncbigene:403998
RBL1 GeneProduct ncbigene:477221 RBL1; retinoblastoma-like 1 (p107)
CDK4 GeneProduct ncbigene:481131 CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDC25C GeneProduct ncbigene:610456 CDC25C; cell division cycle 25C [EC:]
CDC25A GeneProduct ncbigene:484780 CDC25A; cell division cycle 25A [EC:]
TP53 GeneProduct ncbigene:403869
ATM GeneProduct ncbigene:479450 ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:]
ABL1 GeneProduct ncbigene:491292 ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:
SKP2 GeneProduct ncbigene:489228 SKP2; S-phase kinase-associated protein 2 (p45
CDC6 GeneProduct ncbigene:480527 CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
SKP2 GeneProduct ncbigene:489228 SKP2; S-phase kinase-associated protein 2 (p45
CCNA1 GeneProduct ncbigene:477302 CCNA1; cyclin A1
SMAD4 GeneProduct ncbigene:476196 MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
CDKN1A GeneProduct ncbigene:474890
CDK2 GeneProduct ncbigene:606931 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
E2F1 GeneProduct ncbigene:485839 E2F1; E2F transcription factor 1
ATR GeneProduct ncbigene:477101 ATR; ataxia telangiectasia and Rad3 related
E2F4 GeneProduct ncbigene:611243 E2F4; E2F transcription factor 4 p107/p130-binding
LOC478040 GeneProduct ncbigene:478040 HDAC3; histone deacetylase 3
MCM6 GeneProduct ncbigene:476131 MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
CHEK1 GeneProduct ncbigene:609767 CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
LOC475035 GeneProduct ncbigene:475035 HDAC2; histone deacetylase 2
MCM4 GeneProduct ncbigene:477871 MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
CCNA1 GeneProduct ncbigene:477302 CCNA1; cyclin A1
RB1 GeneProduct ncbigene:476915 RB1; retinoblastoma 1 (including osteosarcoma)
ORC5L GeneProduct ncbigene:609937 ORC5L; origin recognition complex subunit 5-like (yeast)
PKMYT1 GeneProduct ncbigene:490050 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
MCM2 GeneProduct ncbigene:484622 MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MAD2L2 GeneProduct ncbigene:487443 MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
CDC2 GeneProduct ncbigene:488997 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
PLK1 GeneProduct ncbigene:489971 PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
ORC2L GeneProduct ncbigene:478868 ORC2L; origin recognition complex subunit 2-like (yeast)
MCM5 GeneProduct ncbigene:610519 MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
DBF4 GeneProduct ncbigene:475219 ASK; activator of S phase kinas
GSK3B GeneProduct ncbigene:478575 GSK3B; glycogen synthase kinase 3 beta [EC:]
CDC2 GeneProduct ncbigene:488997 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
ORC6L GeneProduct ncbigene:482492 ORC6L; origin recognition complex subunit 6-like (yeast)
MCM3 GeneProduct ncbigene:481839 MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
CDC7 GeneProduct ncbigene:479955 CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDC14B GeneProduct ncbigene:476294 CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
E2F6 GeneProduct ncbigene:609996 E2F6; E2F transcription factor 6
PCNA GeneProduct ncbigene:477166 PCNA; proliferating cell nuclear antigen
E2F5 GeneProduct ncbigene:611103 E2F5; E2F transcription factor 5 p130-binding


  1. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia