(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP179&oldid=30295 WP179(r30295)] with a 80% conversion rate.
PTTG3; pituitary tumor-transforming
PTTG1; pituitary tumor-transforming
YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CCNA2; cyclin A2
CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CCNE2; cyclin E
CDC25B; cell division cycle 25B [EC:3.1.3.48]
ORC4L; origin recognition complex subunit 4-like (yeast)
RB1; retinoblastoma 1 (including osteosarcoma)
HDAC4; histone deacetylase 4
CCND2; cyclin D2
PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
EP300; E1A binding protein p300
ORC3L; origin recognition complex subunit 3-like (yeast)
BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
HDAC7A; histone deacetylase 7
RB1; retinoblastoma 1 (including osteosarcoma)
MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
HDAC8; histone deacetylase
CCNH; cyclin H
ESPL1; extra spindle poles like 1 (S. cerevisiae
HDAC1; histone deacetylase 1
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
CCNB2; cyclin B2
CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
HDAC5; histone deacetylase 5
UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
ORC1L; origin recognition complex subunit 1-like (yeast)
HDAC6; histone deacetylase 6
MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
PTTG2; pituitary tumor-transforming
MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CCNE1; cyclin E
CCNB3; cyclin B
CCNA2; cyclin A2
TFDP1; transcription factor Dp-1
E2F3; E2F transcription factor 3
WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CCND3; cyclin D3
RBL1; retinoblastoma-like 1 (p107)
CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC25A; cell division cycle 25A [EC:3.1.3.48]
ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
SKP2; S-phase kinase-associated protein 2 (p45
CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
SKP2; S-phase kinase-associated protein 2 (p45
CCNA1; cyclin A1
MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
CCNB1; cyclin B1
CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
E2F1; E2F transcription factor 1
ATR; ataxia telangiectasia and Rad3 related
E2F4; E2F transcription factor 4 p107/p130-binding
HDAC3; histone deacetylase 3
MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
HDAC2; histone deacetylase 2
MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
CCNA1; cyclin A1
BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
RB1; retinoblastoma 1 (including osteosarcoma)
ORC5L; origin recognition complex subunit 5-like (yeast)
PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
E2F2; E2F transcription factor 2
CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
ORC2L; origin recognition complex subunit 2-like (yeast)
MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
ASK; activator of S phase kinas
GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
ORC6L; origin recognition complex subunit 6-like (yeast)
MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
E2F6; E2F transcription factor 6
PCNA; proliferating cell nuclear antigen
E2F5; E2F transcription factor 5 p130-binding
c78
cell cycle pathway
PW:0001317
Pathway Ontology
9733515
PubMed
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
Science
1998
Canman CE
Lim DS
Cimprich KA
Taya Y
Tamai K
Sakaguchi K
Appella E
Kastan MB
Siliciano JD